Applications and prospects of different functional hydrogels in meniscus repair

Jin, Pan; Liu, Lei; Chen, Xichi; Cheng, Lin; Zhang, Weining; Zhong, Gang

doi:10.3389/fbioe.2022.1082499

Cited by 5 publications

(3 citation statements)

References 167 publications

(258 reference statements)

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“…Owing to its unique buffering, hydration, binding, and load-bearing properties, proteoglycan fills most of the gaps in the tissue in the form of a hydrogel ( Padhi and Nain, 2020 ). Similar to the ECM, hydrogels maintain structural integrity through physical and chemical actions, which make them cell carriers and conducive to creating a microenvironment suitable for cell growth ( Wang and Wang, 2021 ; Jin et al, 2022 ). Hydrogels are highly crosslinked macromolecular hydrated networks.…”

Section: Exosome Combined With Hydrogel In the Treatment Of Iuamentioning

confidence: 99%

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels

Wu,

Lei,

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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Intrauterine adhesion (IUA), also referred to as Asherman Syndrome (AS), results from uterine trauma in both pregnant and nonpregnant women. The IUA damages the endometrial bottom layer, causing partial or complete occlusion of the uterine cavity. This leads to irregular menstruation, infertility, or repeated abortions. Transcervical adhesion electroreception (TCRA) is frequently used to treat IUA, which greatly lowers the prevalence of adhesions and increases pregnancy rates. Although surgery aims to disentangle the adhesive tissue, it can exacerbate the development of IUA when the degree of adhesion is severer. Therefore, it is critical to develop innovative therapeutic approaches for the prevention of IUA. Endometrial fibrosis is the essence of IUA, and studies have found that the use of different types of mesenchymal stem cells (MSCs) can reduce the risk of endometrial fibrosis and increase the possibility of pregnancy. Recent research has suggested that exosomes derived from MSCs can overcome the limitations of MSCs, such as immunogenicity and tumorigenicity risks, thereby providing new directions for IUA treatment. Moreover, the hydrogel drug delivery system can significantly ameliorate the recurrence rate of adhesions and the intrauterine pregnancy rate of patients, and its potential mechanism in the treatment of IUA has also been studied. It has been shown that the combination of two or more therapeutic schemes has broader application prospects; therefore, this article reviews the pathophysiology of IUA and current treatment strategies, focusing on exosomes combined with hydrogels in the treatment of IUA. Although the use of exosomes and hydrogels has certain challenges in treating IUA, they still provide new promising directions in this field.

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Section: Exosome Combined With Hydrogel In the Treatment Of Iuamentioning

confidence: 99%

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels

Wu,

Lei,

Yang

et al. 2023

Front. Bioeng. Biotechnol.

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“…[ 4 ] Currently, the majority of clinical treatments involve suturing, repairing, or excising the damaged area. [ 5 ] Nonetheless, meniscectomy modifies the biomechanical impacts of the knee joint and compromises the joint surface, leading to an increased risk of long‐term osteoarthritis. [ 6 ] Hence, enabling self‐repair of the damaged meniscal morphology is crucial in treating meniscal injuries.…”

Section: Introductionmentioning

confidence: 99%

Advanced Hydrogel Material for Meniscus Repair

Li,

Deng,

Yang

et al. 2024

Adv Funct Materials

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The foundation of regenerative medicine is the investigation and progression of hypotheses and approaches for substituting, mending, reconstructing, or regenerating different tissues and organs within the human body. Nevertheless, due to the slender central segment and the entire unattached configuration of the meniscus, the efficacy of conventional therapies is unsatisfactory in reinstating meniscal health and functionality. To overcome these limitations, medical‐type hydrogels have the potential to provide a solution for meniscus repair and regeneration. Their biocompatibility and modifiability enable safe implantations in vivo, effectively modifying the pathophysiology of cells and the surrounding microenvironment at the site of meniscal injury. This article reviews the usage of different implantable medical‐type hydrogels in meniscal regeneration and repair. First, the structure and physiologic function of the meniscus are first briefly described. Following this, the use of varying hydrogels in meniscus repair is highlighted, alongside a discussion of different materials employed in constructing hydrogel implants. Lastly, an analysis of the issues and challenges associated with hydrogels in meniscus repair is presented.

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“…The use of hydrogel in MTE has been covered by some recent reviews, which featured discussions on hydrogel application in meniscus repair, rehabilitation, and regeneration [44,45]. By conducting a detailed analysis of the available literature in recent decades, our review aims to discuss hydrogel design, with a focus on biomaterial properties and functions, crosslinking strategies, and therapeutic components loaded by hydrogels, including cells and other bioactive additives.…”

Section: Introductionmentioning

confidence: 99%

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

Zhou,

Wang,

Jiang

et al. 2024

Gels

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Meniscus tissue engineering has emerged as a promising strategy for meniscus repair and regeneration. As versatile platforms, hydrogels have gained significant attention in this field, as they possess tunable properties that allow them to mimic native extracellular matrices and provide a suitable microenvironment. Additionally, hydrogels can be minimally invasively injected and can be adjusted to match the shape of the implant site. They can conveniently and effectively deliver bioactive additives and demonstrate good compatibility with other functional materials. These inherent qualities have made hydrogel a promising candidate for therapeutic approaches in meniscus repair and regeneration. This article provides a comprehensive review of the advancements made in the research on hydrogel application for meniscus tissue engineering. Firstly, the biomaterials and crosslinking strategies used in the formation of hydrogels are summarized and analyzed. Subsequently, the role of therapeutic additives, including cells, growth factors, and other active products, in facilitating meniscus repair and regeneration is thoroughly discussed. Furthermore, we summarize the key issues for designing hydrogels used in MTE. Finally, we conclude with the current challenges encountered by hydrogel applications and suggest potential solutions for addressing these challenges in the field of MTE. We hope this review provides a resource for researchers and practitioners interested in this field, thereby facilitating the exploration of new design possibilities.

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Applications and prospects of different functional hydrogels in meniscus repair

Cited by 5 publications

References 167 publications

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels

Treatment strategies for intrauterine adhesion: focus on the exosomes and hydrogels

Advanced Hydrogel Material for Meniscus Repair

Advances in Hydrogels for Meniscus Tissue Engineering: A Focus on Biomaterials, Crosslinking, Therapeutic Additives

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