Lonicerae Flos: A Review of Chemical Constituents and Biological Activities

Tang, Yan-Ran; Zeng, Ting; Zafar, Saima; Yuan, Hanwen; Li, Bin; Peng, Chao; Sicheng, Wang; Jian, Yuqing; Yan, Qin; Choudhary, Muhammad Iqbal; Wang, Wei

doi:10.1016/s2589-3777(19)30022-9

Cited by 19 publications

(26 citation statements)

References 12 publications

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“…Var. mongholicus Astragali radix Fabaceae dried root Astragaloside, Isoastragloside He and Findlay (1991) Dioscorea opposita Thunb Chinese yam Dioscoreaceae root Diosgenin Zhang et al (2014b) Dryopteris crassirhizoma thick stemmed wood fern Dryopteridaceae Root hexacosanic acid, pentacosanol, nerolidol, dryocrassin ABBA, flavaspidic acid AB Gao et al (2003) Ephedra sinica Ephedraceae stem ephedrine, pseudoephedrine, N-methylephedrine, and 6-methoxykynurenic acid Zhao et al (2009) Ephedrae herba Ephedraceae Aerial parts (−)-ephedrine, (+)-pseudoephedrine, (−)-methylephedrine, (+)-methylpseudoephedrine, (−)-norephedrine, and (+)-norpseudoephedrine Liu et al (1993) Glycine max L. Merill Fermented soy, Natto Fermented bean Globulins, β-conglycinin, glycinin Yang et al (2011) Lonicera macranthoides Hand.-Mazz., Lonicera hypoglauca Miq., Lonicera confusa DC and Lonicera fulvotomentosa Shan Yin Hua Caprifoliaceae Dried leaves 200 compounds have been isolated and identified, mostly falavonoids and essential oil, Caffeic acid, Chlorogenic acid, Macranthoin F Tang et al (2018) Arctium lappa L. Seeds of burdock fruit Caprifoliaceae dried fruits Arctiin, Arctigenin, Matairesinol …”

Section: Medicinal Plants For Viral Respiratory Infections (Vri)mentioning

confidence: 99%

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Khan

Mashwani

et al. 2021

Biocatalysis and Agricultural Biotechnology

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Section: Medicinal Plants For Viral Respiratory Infections (Vri)mentioning

confidence: 99%

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Khan

Mashwani

et al. 2021

Biocatalysis and Agricultural Biotechnology

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“…Lonicerae Flos (LF, Shanyinhua in Chinese) is one of the most commonly used traditional Chinese medicines [1], which has been officially listed in Chinese Pharmacopeia (Edition 2020) and described as "Used for carbuncle boils, throat arthralgia, erysipelas, toxic blood dysentery, wind-heat cold, febrile fever". LF is the dried flower buds or opening flowers of four plants (Lonicera macranthoides, L. hypoglauca, L. confusa, and L. fulvotnetosa) [2], and they are widely cultivated in Southern China.…”

Section: Introductionmentioning

confidence: 99%

“…The comparative analysis focuses on features, structure, nucleotide diversity, simple sequence repeats (SSRs) and phylogenetic analysis. The aims of our study are: (1) to comprehensive understanding the complete cp genome features from four origin plants of LF, (2) to the systematic analysis of similarities and differences from the four origin plants, (3) to infer the phylogenetic relationship among the four and between the four and Lonicerae Japonicae Flos (LJF, Jinyinhua in Chinese, L. japonica,), and (4) to provide genetic resources for developing chloroplast markers to identify LF species and future research on Lonicera.…”

Section: Introductionmentioning

confidence: 99%

Comparative Analysis of the Complete Chloroplast Genome Sequences of Four Origin Plants of Lonicerae Flos (Lonicera; Caprifoliaceae)

Liu¹,

Zhou²,

Huang³

et al. 2022

Phyton

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Lonicerae Flos (LF) derived from the dried flower buds or opening flowers of four Lonicera plants (Lonicera macranthoides, L. hypoglauca, L. confusa, and L. fulvotnetosa), is a popular traditional Chinese medicine. Because the four origin plants are very similar in morphology, it is difficult to control the quality of LF in actual production. Over the past decade, many reports have pointed out the differences among them, including the botanical characteristics and active ingredients. However, there is still a lack of rapid methods that can be applied to the identification of the four origins. In this study, comparative analysis of the four chloroplast genomes was performed, and they showed low diversity (Pi = 0.00267), three variation hotspots regions (rbcL-accD, rps12-ndhF and rps12-trnN-trnG) were identified as potentially molecular marker of highly informative. Meanwhile, the most obvious difference in SSR comparative analysis is reverse and complement repeats were only identified in L. confusa and L. hypoglauca, respectively. Lastly, the phylogenetic tree showed that L. confusa is more closely related to L. fulvotnetosa, while L. macranthoides is closer to L. hypoglauca. This study systematically revealed the differences among the four chloroplast genomes, and it provides valuable genetic information for identifying the origin of LF.

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“…LJF has glucose-lowering, anti-ultraviolet radiation, anti-endotoxin, anti-ulcer, anti-early pregnancy, anti-platelet aggregation, anti-fertility, and neuroprotective activities that are not reported in LF, while LF has effects on balancing intestinal flora and anti-atherosclerotic effects that are not reported in LJF [ 3 ]. In recent years, the commercial value of LJF in herbal medicine trading markets has increased by over 400%, and more than 30% of current traditional Chinese medicine prescriptions contain LJF [ 4 ]. As a result, LF is often misused as LJF by some pharmaceutical factories to obtain higher interest.…”

Section: Introductionmentioning

confidence: 99%

Discrimination and Prediction of Lonicerae japonicae Flos and Lonicerae Flos and Their Related Prescriptions by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy Combined with Multivariate Statistical Analysis

Tang

Lin

et al. 2022

Molecules

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LJF and LF are commonly used in Chinese patent drugs. In the Chinese Pharmacopoeia, LJF and LF once belonged to the same source. However, since 2005, the two species have been listed separately. Therefore, they are often misused, and medicinal materials are indiscriminately put in their related prescriptions in China. In this work, firstly, we established a model for discriminating LJF and LF using ATR-FTIR combined with multivariate statistical analysis. The spectra data were further preprocessed and combined with spectral filter transformations and normalization methods. These pretreated data were used to establish pattern recognition models with PLS-DA, RF, and SVM. Results demonstrated that the RF model was the optimal model, and the overall classification accuracy for LJF and LF samples reached 98.86%. Then, the established model was applied in the discrimination of their related prescriptions. Interestingly, the results show good accuracy and applicability. The RF model for discriminating the related prescriptions containing LJF or LF had an accuracy of 100%. Our results suggest that this method is a rapid and effective tool for the successful discrimination of LJF and LF and their related prescriptions.

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Lonicerae Flos: A Review of Chemical Constituents and Biological Activities

Cited by 19 publications

References 12 publications

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Therapeutic potential of medicinal plants against COVID-19: The role of antiviral medicinal metabolites

Comparative Analysis of the Complete Chloroplast Genome Sequences of Four Origin Plants of Lonicerae Flos (Lonicera; Caprifoliaceae)

Discrimination and Prediction of Lonicerae japonicae Flos and Lonicerae Flos and Their Related Prescriptions by Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy Combined with Multivariate Statistical Analysis

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