?Longitudinal Water Proton Relaxivities of Ultra Small 3d and 4f Transition Metal Oxide Nanoparticles

Lee, Gang Ho; Choi, Eunsuk; Park, Ja Young; Kattel, Krishna; Xu, Wenlong; Baek, Myung Ju; Kim, Joo Hyun; Chang, Yongmin; Kim, Tae Jeong

doi:10.3938/jkps.56.1532

Cited by 7 publications

(1 citation statement)

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“…The inner-sphere contribution is correlated with the core of nanoparticles dominates the inner-sphere interactions, while the second-and outer-sphere contributions are greatly influenced by the water-dispersible layer. [83][84][85] However, only the Gd 3+ on the outer surface of nanoparticles are able to interact with water molecules and enhance the longitudinal relaxivity. 83 Therefore, efforts should be devoted to increasing the surface-chelated Gd 3+ in order to improve the general performance of Gd-CNDs in MRI.…”

Section: Gd-cnds As Mri Contrast Agentsmentioning

confidence: 99%

When rare earth meets carbon nanodots: mechanisms, applications and outlook

et al. 2020

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Section: Gd-cnds As Mri Contrast Agentsmentioning

confidence: 99%

When rare earth meets carbon nanodots: mechanisms, applications and outlook

et al. 2020

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Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

et al. 2015

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Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T₁-Weighted Contrast-Enhanced Brain Imaging

Wei

Liu

Zhang

et al. 2022

ACS Appl. Mater. Interfaces

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Manganese oxide nanoparticles (NPs) have attracted increasing attention recently as contrast agents (CAs) for magnetic resonance imaging (MRI). However, the clinical translation and popularization of conventional MnO NPs are hampered by their relatively poor imaging performance. Herein, we report the construction of ultrasmall MnO NPs (USMnO) via a one-pot synthetic approach that show a much better capability of T 1 -weighted contrast enhancement for MRI (r 1 = 15.6 ± 0.4 mM −1 s −1 at 0.5 T) than MnCl 2 and conventional large-sized MnO NPs (MnO-22). These USMnO are further coated with zwitterionic dopamine sulfonate (ZDS) molecules, which improves their biocompatibility and prevents nonspecific binding of serum albumins. Interestingly, USMnO@ZDS are capable of passing through the blood−brain barrier (BBB), which enables the acquisition of clear images showing brain anatomic structures with T 1 -weighted contrast-enhanced MRI. Therefore, our USMnO@ZDS could be used as a promising MRI CA for the flexible and accurate diagnosis of brain diseases, which is also instructive for the construction of manganese-based CA with a high MRI performance.

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?Longitudinal Water Proton Relaxivities of Ultra Small 3d and 4f Transition Metal Oxide Nanoparticles

Cited by 7 publications

References 0 publications

When rare earth meets carbon nanodots: mechanisms, applications and outlook

When rare earth meets carbon nanodots: mechanisms, applications and outlook

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T₁-Weighted Contrast-Enhanced Brain Imaging

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?Longitudinal Water Proton Relaxivities of Ultra Small 3d and 4f Transition Metal Oxide Nanoparticles

Cited by 7 publications

References 0 publications

When rare earth meets carbon nanodots: mechanisms, applications and outlook

When rare earth meets carbon nanodots: mechanisms, applications and outlook

Lanthanide Nanoparticles: From Design toward Bioimaging and Therapy

Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T1-Weighted Contrast-Enhanced Brain Imaging

Contact Info

Product

Resources

About

Zwitterion-Coated Ultrasmall MnO Nanoparticles Enable Highly Sensitive T₁-Weighted Contrast-Enhanced Brain Imaging