Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation

Parkitny, Luke; Carter, C. Sue; Peckins, Melissa K.; Hon, Deirdre Ann; Saturn, Sarina R.; Pournajafi-Nazarloo, Hossein; Hurlbut, William B.; Knutson, Brian; Crane, Steven A.; Harris, Xiola; Younger, Jarred

doi:10.1016/j.cpnec.2021.100105

Cited by 6 publications

(4 citation statements)

References 51 publications

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“…Moreover, our results demonstrate that the controls assessed all tactile stimuli, and above all C-tactile afferent stimulation, as significantly more pleasant than the participants with ASD. According to the previous findings, we suggest that an increase in oxytocin level after the stimulation in the ASD group could be attributed, rather, to the stress-induced response than to positive emotions caused by pleasant sensations [60][61][62]. The EEG findings also support the theory of stressinduced oxytocin release in subjects with ASD.…”

Section: Discussionsupporting

confidence: 79%

Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder

Portnova

Проскурнина

Skorokhodov

et al. 2023

IJMS

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Individuals with ASD are known to have a tendency to have tactile sensory processing issues that could be associated with their impairment as regards social communication. The alterations in tactile processing in autistic subjects are usually accompanied by hypersensitivity and other unpleasant emotions induced by tactile contact. In our study, we investigated the impact of the velocity and the force of a tactile stroke received impersonally by a custom-built robotic device. A total of 21 adults with ASD and 22 adults from a control group participated in our study. The participants’ responses were assessed according to subjective scales, EEG changes, and the dynamics of saliva antioxidants and oxytocin. It was found that the oxytocin level was significantly lower in subjects with ASD but increased after tactile stimulation. However, contrary to expectations, the increase in the oxytocin level in the target group negatively correlated with the subjective pleasantness of tactile stimulation and was probably associated with a stress-induced effect. The basic levels of antioxidants did not differ between the TD and ASD groups; however, these had significantly increased in individuals with ASD by the end of the study. The EEG findings, which revealed enhanced antioxidant levels, contributed to the relief of the cognitive control during the study.

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Section: Discussionsupporting

confidence: 79%

Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder

Portnova

Проскурнина

Skorokhodov

et al. 2023

IJMS

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“…Perhaps positive responders in this study also experienced a greater release of oxytocin and increased HRV during the elevation exercises, which could potentially impact outcomes. Notably, one elevation study found oxytocin responses were heterogenous, such as the distinct differences in cortisol responses for this study (Parkitny et al, 2022). The authors suggested differences could be attributed to individual psychological characteristics including history of trauma (Ellis et al, 2021).…”

Section: Nonresponders Summarymentioning

confidence: 76%

Biopsychosocial Correlates and Individual Differences for Eliciting Moral Elevation in Veterans With PTSD

McGuire,

Howard,

Burns

et al. 2023

J Nerv Ment Dis

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A promising approach to enhancing trauma-focused treatment is moral elevation—feeling inspired by witnessing a virtuous act. This study explored potential links between eliciting elevation and relevant outcomes in a series of case examples. Veterans with probable posttraumatic stress disorder completed experimental tasks including a written trauma narrative exercise and watching elevation-eliciting videos. Participants also completed baseline assessments, repeated measures of trauma-related cognitions, emotions, elevation, and saliva sample collection. Four cases were identified and reviewed: two positive responders (high elevation after videos) and two nonresponders (restricted elevation response). Positive responder cases reported decreased cognitions, emotions, and moral injury distress from after the trauma narrative to after elevation exercises, whereas nonresponders reported minimal to no changes. Positive responders also demonstrated decreases in cortisol, whereas nonresponders demonstrated increases in cortisol. Future work should examine whether elevation contributes to changes in biopsychosocial outcomes and identify individual factors that indicate who might benefit from elevation-based interventions.

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“…The basic factors responsible for the release of oxytocin are not well understood. Oxytocin can be difficult to measure with marked individual differences in its release [ 12 ] and its effects on both the oxytocin and vasopressin receptors. Failure to recognize the importance of early nurture can have disastrous and lasting consequences, including reduced capacity to manage later traumas, adversities and all aspects of health [ 2 ].…”

Section: Nature Via Nurturementioning

confidence: 99%

Love and fear: A special issue

Carter

Dantzer

2022

Comprehensive Psychoneuroendocrinology

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Longitudinal tracking of human plasma oxytocin suggests complex responses to moral elevation

Cited by 6 publications

References 51 publications

Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder

Salivary Oxytocin and Antioxidative Response to Robotic Touch in Adults with Autism Spectrum Disorder

Biopsychosocial Correlates and Individual Differences for Eliciting Moral Elevation in Veterans With PTSD

Love and fear: A special issue

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