Love and fear: A special issue

Carter, C. Sue; Dantzer, Robert

doi:10.1016/j.cpnec.2022.100151

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Third, some authors have recommended sample extraction prior to assay for measuring OT; as unextracted samples provide higher levels than those that are extracted ( 82 ). As explained elsewhere, OT has unique properties that make this molecule both biologically active and difficult to measure ( 60 , 83 ). However, recent research suggests that this discrepancy in estimates of OT may result from the removal of bound OT during the extraction step ( 60 , 84 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship between endogenous oxytocin and vasopressin levels and the Prader-Willi syndrome behaviour phenotype

Rice,

Agu,

Carter

et al. 2023

Front. Endocrinol.

Self Cite

View full text Add to dashboard Cite

BackgroundOxytocin and vasopressin systems are altered in Prader Willi syndrome (PWS). However, investigations into endogenous oxytocin and vasopressin levels as well as clinical trials evaluating the effect of exogenous oxytocin on PWS symptoms have had mixed results. It is also unknown whether endogenous oxytocin and vasopressin levels are associated with certain PWS behaviours.MethodWe compared plasma oxytocin and vasopressin and saliva oxytocin levels in 30 adolescents and adults with PWS to 30 typically developing age-matched controls. We also compared neuropeptide levels between gender and genetic subtypes within the PWS cohort and examined the relationship between neuropeptide levels and PWS behaviours.ResultsWhile we did not measure a group difference in plasma or saliva oxytocin levels, plasma vasopressin was significantly lower in individuals with PWS compared to controls. Within the PWS cohort, saliva oxytocin levels were higher in females compared to males and individuals with the mUPD compared to the deletion genetic subtype. We also found the neuropeptides correlated with different PWS behaviours for males and females and for genetic subtypes. For the deletion group, higher plasma and saliva oxytocin levels were related to fewer behaviour problems. For the mUPD group, higher plasma vasopressin levels were related to more behaviour problems.ConclusionThese findings support existing evidence of a vasopressin system defect in PWS and for the first time identify potential differences in the oxytocin and vasopressin systems across PWS genetic subtypes.

show abstract