Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey

Abstract

Anterograde tracing methods were used to examine the topographic organization and interrelationship of projections to the neostriatum arising from various areas of association cortex. In contrast to the currently accepted topographic schema, all cortical areas examined project to longitudinal territories that occupy restricted medial-lateral domains of the neostriatum. The posterior parietal and superior arcuate cortices project to dorsolateral portions of the neostriatum; the dorsolateral and dorsomedial frontal cortices project centrally; and the orbitofrontal, anterior cingulate, and superior temporal projections are distributed to ventromedial regions of the caudate nucleus and putamen. In coronal section, cortical terminal fields form a diagonal strip, extending from the dorsal, ventricular border of the caudate nucleus, through the fiber bundles of the internal capsule, to the ventral margin of the putamen. Double labeling studies, in which two cortical areas were injected in the same animal, indicated that convergence of input within neostriatal domains is not governed by reciprocity of corticocortical connectivity. Thus, the interrelationship of projections arising from connectionally linked cortical areas ranged from nearly complete segregation of terminal fields (e.g., from dorsolateral prefrontal and orbital cortices) to extensive overlap of terminal domains (e.g., from frontal and temporal cortices). In the latter case, detailed analysis revealed that frontal and temporal terminals actually were interdigitated rather than intermixed within the zone of overlap. The present findings suggest a new conceptualization of corticostriatal topography in the primate which emphasizes the longitudinal arrangement of cortical terminal domains. Additionally, these findings provide a map for functional parcellation of the neostriatum on the basis of its cortical innervation which may prove useful to understanding normal striatal function, as well as the symptomatology associated with neostriatal injury and disease.

Cannabinoid Modulation of Functional Connectivity within Regions Processing Attentional Salience

“…Functional interaction of specific structures involved in salience processing, as identified in this study, is also in accordance with findings from human functional and structural imaging studies (Burianova et al, 2010) as well as mapping studies in primates (Selemon and Goldman-Rakic, 1985) that demonstrate their anatomical and functional relationship. Functional connectivity between the striatum and inferior frontal cortex was attenuated by delta-9-THC.…”

The Reward Circuit: Linking Primate Anatomy and Human Imaging

“…Within each general functional region (limbic, associative, and motor), terminals are also topographically organized. Thus, inputs from the vmPFC, OFC, and dACC terminate within subregions of the VS, and the dPFC terminates primarily in the caudate nucleus (Haber et al, 1995a;Selemon and Goldman-Rakic, 1985). The focal projection field from the vmPFC is the most limited.…”

A three-dimensional, histological and deformable atlas of the human basal ganglia. I. Atlas construction based on immunohistochemical and MRI data

“…This subdivision which processes sensorimotor information is referred to as the sensorimotor territory. A second subdivision arises from the prefrontal, posterior parietal and temporal associative cortices and terminates mainly in the caudate nucleus without any clear-cut somatotopic organization (Selemon and Goldman-Rakic, 1985;Yeterian and Pandya, 1991). This subdivision, referred to as the associative territory, processes cognitive information.…”