Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa

Sayo, Akira; Ueno, Shinji; Kominami, Taro; Nishida, Kazuki; Inooka, Daiki; Nakanishi, Atsuko; Yasuda, Shunsuke; Okado, Satoshi; Takahashi, Kunihiko; Matsui, Shigeyuki; Terasaki, Hiroko

doi:10.1038/s41598-017-16640-7

Cited by 21 publications

(29 citation statements)

References 26 publications

(39 reference statements)

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“…The second explanation is the great heterogeneity of macular involvement among RP patients illustrated by the large number of causative genes, which cause various underlying biochemical pathways. [16][17][18] In certain RP subtypes, macular degeneration occurs relatively early in the disease course. 19 In this type, the EZ in the macular area might disappear evenly, which is different from a shorting of the EZ, and the curvature might be unchanged.…”

Section: Discussionmentioning

confidence: 99%

Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

Komori

Ueno

Ito

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. A posterior staphyloma has been reported to be present in some eyes with retinitis pigmentosa (RP), and the purpose of this study was to determine the macular curvature of non-highly myopic RP eyes. METHODS. This was a retrospective, observational study. The medical charts of the right eyes of 143 patients with RP and 60 controls whose axial length ranged from 21.5 mm to 26.0 mm were reviewed. The mean curvature of Bruch's membrane within 6 mm of the central macula obtained from the horizontal optical coherence tomographic images were evaluated as the mean macular curvature index (MMCI). The relationships between the MMCI and other clinical factors were assessed. RESULTS. The mean MMCI of RP patients (À13.73 6 9.63 3 10 À5 lm À1) was significantly lower than that of the controls (À6.63 6 5.63 3 10 À5 lm À1). This indicated a deeper concave shape of the macula in RP eyes (P < 0.001). The MMCI was significantly correlated with the age (r ¼ 0.20; P ¼ 0.016) and the axial length (r ¼ À0.24; P ¼ 0.004). Further analysis suggested a nonlinear effect of the ellipsoid zone width on the macular curvature in the RP eyes. CONCLUSIONS. There is a high incidence of steeper macular curvatures even in non-highly myopic RP eyes, and the steepness was also affected by the degree of photoreceptor degeneration.

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Section: Discussionmentioning

confidence: 99%

Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

Komori

Ueno

Ito

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Goldmann perimetry test results showed similar progression of her peripheral visual field loss, and the MD slope was similar. Given that the values obtained for the right eye at the first examination may be an outlier, the progression of sensitivity loss of would be almost identical in both eyes and comparable with the reported average of − 0.46 dB/year [ 8 ]. Overall, long-term anti-VEGF therapy did not induce rapid progression of central or peripheral visual field loss in this patient.…”

Section: Discussionmentioning

confidence: 61%

Long-term efficacy and safety of anti-VEGF therapy in retinitis pigmentosa: a case report

Miyata

Oishi

et al. 2018

BMC Ophthalmol

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BackgroundRetinitis pigmentosa (RP), a neurodegenerative disease, is occasionally accompanied by choroidal neovascularization (CNV) and cystoid macular oedema. It is presently treated with repeated intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. However, there are concerns regarding long-term inhibition of VEGF by the use of these agents, especially in cases involving neurodegenerative diseases, since VEGFs have a neuroprotective effect. Currently, there are no reports on the long-term safety of anti-VEGF therapy in patients with RP.Case presentationIn this report, we describe the case of a 56-year-old female patient with CNV associated with RP who was treated with anti-VEGF therapy for 8 years. She had autosomal dominant RP with a heterozygous PRPH2 mutation (c.410G > A) and complained of metamorphopsia in her left eye. Examinations revealed CNV with serous retinal detachment. She was treated with as-needed injections for 2 years; however, she experienced a recurrence. Therefore, we switched to a bimonthly regimen that was continued for 6 years. In total, the patient received 34 injections of various types of anti-VEGFs over 8 years. No recurrences were noted during that time, and we have not detected any negative effects concerning the progression of visual field loss in comparison with the fellow eye.ConclusionsNo negative effects related to the progression of visual field loss were observed during continuous treatment with anti-VEGF agents for 8 years in our patient.

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“…However, It may be unsuitable to average the sensitivities (dB) of each point because the dB is logarithmic scale. When calculating MS and FS, Sayo converted dB to 1/Lambert, and then average the values, not simply to average the sensitivities (dB) 32 . In future study, this method seem to be standard for measurement of retinal sensitivities.…”

Section: Discussionmentioning

confidence: 99%

“…In future study, this method seem to be standard for measurement of retinal sensitivities. Moreover, further studies are needed to compare the both macular sensitivities calculated by threshold sensitivities or based upon TD plot values, as Sayo described 32 . Second, RP is caused by mutations in more than 50 responsible genes 33 , and RP patient series therefore present a genetically heterogeneous group of retinal degenerative diseases.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Central Visual Function in Patients with Retinitis Pigmentosa

Fujiwara

Ikeda

Murakami

et al. 2018

Sci Rep

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In order to clarify the disease progression in retinitis pigmentosa (RP) and its related factors, reliable data on the changes in central visual function in RP are needed. In this longitudinal study, we examined 118 patients who were diagnosed with typical RP. Visual acuity (VA), visual field using a Humphrey Field Analyzer with the central 10-2 SITA-Standard program, and optical coherence tomography measurements were obtained. The slopes, which were derived from serial values of mean deviation (MD), macular sensitivity (MS), or foveal sensitivity (FS) obtained for each eye by a linear mixed model, were used for analysis. MS and FS were calculated as the average retinal sensitivity of 12 and 4 central points respectively. There were statistically significant interactions of times with levels of the central subfield thickness (CST) on the slopes of MS and FS. Compared to the eyes without macular complications, the eyes with macular complications had steeper MD, MS and FS slopes, and this interaction was no significant, but marginal trend for the MS or FS slope (P = 0.10, 0.05, respectively). The central retinal sensitivity (i.e., MS and FS) slopes calculated were effective indices of the progression of central visual function in RP.

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Longitudinal study of visual field changes determined by Humphrey Field Analyzer 10-2 in patients with Retinitis Pigmentosa

Cited by 21 publications

References 26 publications

Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

Steeper Macular Curvature in Eyes With Non-Highly Myopic Retinitis Pigmentosa

Long-term efficacy and safety of anti-VEGF therapy in retinitis pigmentosa: a case report

Assessment of Central Visual Function in Patients with Retinitis Pigmentosa

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