Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy

Matorras, Roberto; Ruíz, José Ignacio; Perteagudo, Lourdes; Barbazán, M.J.; Diaz, Arantza; Valladolid, Amelia; Sanjurjo, Pablo

doi:10.1515/jpm.2001.042

Cited by 31 publications

(21 citation statements)

References 17 publications

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“…Maternal plasma DHA content commonly declines during pregnancy (Al et al, 1995a;Otto et al, 1997;Matorras et al, 2001), particularly in later pregnancy (Knopp, 1991) when foetal requirements for LCPUFA are highest (Clandinin, 1999;Al et al, 2000). In the current study, this pattern was not observed in the control group, possibly because the initial maternal stores were higher than reported in other populations (Matorras et al, 2001).…”

Section: Discussioncontrasting

confidence: 65%

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition

et al. 2004

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Objective: The aim of this study was to assess the effects of fish oil supplementation in pregnancy on maternal erythrocyte fatty acid composition at different stages of pregnancy and in the post-partum period, and on neonatal erythrocyte fatty acid composition. Design: A double-blind, randomised, placebo-controlled study. Setting: Subiaco, Western Australia. Subjects: In all, 98 women booked for delivery at St John of God Hospital, Subiaco, were recruited from private rooms of obstetricians. In total, 83 women and their healthy full-term babies completed the study. Intervention: Women received either 4 g of fish oil (n ¼ 52) (56% docosahexaenoic acid (DHA) and 28% eicosapentaenoic acid (EPA) or placebo (olive oil) (n ¼ 46) per day from 20 weeks gestation until delivery. Main outcome measures: Erythrocyte phospholipid fatty acids were measured in maternal peripheral blood at 20, 30 and 37 weeks of pregnancy and at 6 weeks post partum, and from cord blood collected at birth. Results: Compared to the control group, maternal EPA and DHA were significantly higher in the fish oil group at 30 and 37 weeks gestation, and remained elevated at 6 weeks post partum (Po0.001). The proportions of n-6 polyunsaturated (arachidonic acid, 22:3n-6 and 22:4n-6) were significantly lower in the fish oil supplemented group at the same time periods (Po0.001). Similarly, the proportions of EPA and DHA were significantly higher (Po0.001), and those of n-6 polyunsaturated fatty acids arachidonic acid, 20:3n-6, 22:3n-6 and 22:4n-6 were significantly lower (Po0.001), in erythrocytes from neonates in the fish oil group, compared to those in the control group. Conclusion: Fish oil supplementation from 20 weeks of pregnancy until birth is an effective means of enhancing n-3 fatty acid status of both mothers and neonates. Furthermore, the changes in maternal erythrocyte fatty acid composition are retained until at least 6 weeks post partum. It is essential to assess the effects of concomitant decreases in arachidonic acid status before any dietary recommendations can be made.

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Section: Discussioncontrasting

confidence: 65%

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition

et al. 2004

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“…Table 3 shows that all the parameters were insignificantly higher in the first trimester. Findings of the other studies [37,38] are similar to our findings. In pregnancy, serum total cholesterol and HDL-cholesterol levels show increases parallel with the months of pregnancy, especially during late pregnancy.…”

Section: Discussionsupporting

confidence: 93%

Anti-Müllerian Hormone (AMH) in Adults with Polycystic Ovary Syndrome and Pregnants

Sarıyıldız¹

2016

Eu Clin Anal Med

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ÖzetAmaç: Çalışmada puberta öncesi ve sonrası sağlıklı kız çocukları; over kistli yetişkinler ile hamilelerde anti-Müllerian hormonu AMH ve bazı biyokimyasal parametrelerin karşılaştırılmaları yoluyla değişimin saptanması amaç-landı. Gereç ve Yöntem: Bu çalışma Dr. Faruk Sükan Doğum ve Çocuk Hastanesinin polikliniklerine başvuran ve herhangi bir metabolik hastalığı olmayan dört grupta yer alan toplam100 katılımcı üzerinde gerçekleştirildi. Çalış-maya 7-12 yaş arası prepubertal dönemdeki kız çocuklarından (n=25), 18-24 yaş arası over kist sendromlu (n=25), 18-25 yaş arası hamileliğin 1.trimesterindeki kadınlardan (n=25) ve 18-24 yaş arası (n=25) sağlıklı bireyler kontrol grubu olarak alındı. Bulgular: Prepubertal dönemde (7-12 yaş arası) 25 kız çocuğu ile kontrol grubu(18-24 yaş arası) 25 kız çocuğu AMH değerle-ri sırasıyla 3,62 pg/dl; 3,60 pg/dl olarak bulundu (p═0,7636). Çalışmada over kist sendromlu grubun (18-24 yaş arası) AMH seviyesi 4,11 pg/dL (p═0,8690) olarak bulundu. Tartışma: AMH'nin klinik çalışmalarda over rezervinin tespit edilmesinde kullanılması infertilite tedavisinin ve yardımcı üreme tekniklerinin başarısını önceden tahmin etme ve PKOS'un teşhisi anlamında avantajlar sağlamaktadır. Anahtar KelimelerAnti-Müllerian Hormon; Over Kisti; Hamilelik; Fertilite AbstractAim: The aim of the study was to investigate serum anti-Müllerian hormone (AMH) and various biochemical parameter levels in healthy females before and after puberta, adults with polycystic ovary syndrome and pregnant women. Material and Method: The present study was performed on 100 female volunteers in four groups who applied to the polyclinic in Dr. Faruk Sukan maternal and children hospital and who had no metabolic syndrome.The groups were classified as: group 1: 7-12 years of age, prepubertal period (n=25); group 2: 18-25 years of age, pregnant females in the first trimester (n=25); group 3: 18-24 years of age, suffering from ovarian cysts (n=25); group 4: 18-24 years of age postpubertal as a control group (n=25). Results: The levels of AMH were found in prepubertal females (age 7-12) and the control group (age 18-24) as 3.62 pg/dl and 3.60 pg/dl, respectively (p=0.7636). The levels of AMH were 4.11 pg/dl (p=0.8690) in the women suffering from polycystic ovary syndrome. Discussion: The use of AMH in the measurement of ovarian reserve in clinical trials provides an advantage in early diagnosis of infertility and polycystic ovary syndrome (PCOS).

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“…During pregnancy, there is a faster turnover of PUFA from fast storage that may modify the profile of erythrocyte cell membrane fatty acids [15]. A significant decrease in the proportion of n-3 PUFA from the first to the third trimester has been noted [21]. Thus, it is suggested that n-3 PUFA intake during pregnancy should be increased in the last trimester.…”

Section: Smoking Hormonal Contraception Pregnancy and Premenstrual mentioning

confidence: 99%

Alteration of polyunsaturated fatty acid status and metabolism in health and disease

Zamaria¹

2004

Reprod. Nutr. Dev.

119

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-Essential polyunsaturated fatty acids (PUFA) cannot be synthesised in the body and must be ingested by food. A balanced intake of both n-6 and n-3 PUFA is essential for good health. PUFA are the basic constituents of phospholipid membranes and determine cellular membrane fluidity and modulate enzyme activities, carriers and membrane receptors. They are also precursors of active metabolites known collectively as eicosanoids (prostaglandins, prostacyclins, thromboxanes and leukotrienes) which regulate our cellular functions. Studies indicate that n-3 PUFA have anti-inflammatory, antithrombotic, antiarrhythmic actions and immuno-modulating properties. Erythrocyte fatty acid status is a reflection of dietary fat intake. It also explores PUFA metabolism and gives information about the integration of these fatty acids into cellular membranes. Thus, erythrocyte fatty acid analysis can detect PUFA insufficiencies and imbalances from the diet, but also metabolic abnormalities and lipid peroxidation. It can be helpful in the prevention and the control of chronic diseases in which PUFA alterations have been observed as coronary heart diseases, hypertension, cancer, diabetes, inflammatory and auto-immune disorders, atopic eczema, Alzheimer dementia, major depression, schizophrenia, multiple sclerosis, etc.essential fatty acids / erythrocytes / metabolism / chronic diseases

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Longitudinal study of fatty acids in plasma and erythrocyte phospholipids during pregnancy

Abstract: There was a significant decrease in the proportion of omega 3 PUFA in plasma from the first to the third trimester. Thus, it is suggested that the omega 3 PUFA intake during pregnancy should be increased in the last trimester.

Cited by 31 publications

References 17 publications

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition

Effects of n-3 polyunsaturated fatty acid supplementation in pregnancy on maternal and fetal erythrocyte fatty acid composition

Anti-Müllerian Hormone (AMH) in Adults with Polycystic Ovary Syndrome and Pregnants

Alteration of polyunsaturated fatty acid status and metabolism in health and disease

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