Longitudinal Study Investigating the Relationship between Disease Activity and Psychological Status of Patients with Behçet’s Disease

Zulfiqar, Mehwaish H; Shamdas, Mohith; Bashir, Abida; Douglas, Sarah; Murray, Philip I.

doi:10.1080/09273948.2019.1616770

Cited by 7 publications

(4 citation statements)

References 26 publications

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“…Patients with AIDs should also be followed with clinical evaluation, laboratory test, QoL, tolerance, and treatment adherence. Relationships of patient-parent reported outcomes with disease activity have been studied in juvenile idiopathic arthritis (JIA) ( 20 – 26 ), juvenile idiopathic myositis ( 23 ), rheumatoid arthritis ( 27 – 29 ), systemic lupus erythematosus (SLE) ( 30 – 35 ), Behcet disease ( 36 ), and ankylosing spondylitis (AS) ( 34 , 37 ). The data on the relationship between disease activity and patient-parent reported outcomes in FMF are very limited.…”

Section: Discussionmentioning

confidence: 99%

Number of Episodes Can Be Used as a Disease Activity Measure in Familial Mediterranean Fever

et al. 2022

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ObjectiveTo evaluate the number of episodes in the past 12 months as an indicator of the overall disease activity status in Familial Mediterranean fever (FMF).MethodsIn this cross-sectional study, patients were recruited from tertiary pediatric hospitals. Demographic data, main clinical symptoms of the episodes, treatment modalities, and genetic mutations were recorded. The patients were grouped as no episodes (Group 1), 1–4 episodes (Group 2), and more than 4 episodes (Group 3) according to the number of episodes in the past 12 months. The Pediatric Quality Life Inventory (PedsQL), the Children’s Depression Inventory (CDI), and the Wong-Baker FACES Pain Rating Scale (FACES) scores were compared between groups. Concurrent validity between the number of episodes and the patient-reported outcome measures (PROMs) was assessed using Spearman’s rank correlation coefficient (ρ).ResultsA total of 239 patients were included. There were 74 patients (31%) in Group 1, 99 (41.4%) in Group 2, and 66 (27.6%) in Group 3. Groups were similar according to age, age at diagnosis, gender, consanguinity, family history, history of amyloidosis, clinical symptoms, and in terms of allele frequency (p > 0.05). According to PROMs completed by parents, moderate correlations were found between the number of episodes and the PedsQL score (ρ = −0.48; 95% CI = −0.58 to −0.35, p < 0.001) and between the number of episodes and the Wong-Baker FACES score (ρ = 0.47, 95% CI = 0.35–0.57, p < 0.001).ConclusionThe number of episodes was positively and moderately correlated with patient- and parent-reported outcomes in our cohort. The number of episodes in patients with FMF can be used as a single measure to assess disease activity.

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Section: Discussionmentioning

confidence: 99%

Number of Episodes Can Be Used as a Disease Activity Measure in Familial Mediterranean Fever

et al. 2022

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“…Depression or anxiety did not correlate with the duration of uveitis or visual acuity in the better-seeing eye but patients with posterior or panuveitis had worse depression scores. A study including 102 patients with BD associated uveitis reported a mean score of 11.5 on the PHQ-9, equivalent to moderate depression, and 8.26 on the GAD-7, equivalent to mild anxiety [28]. Physician and patient perception of disease activity, rather than the actual disease activity score, correlated with depression and anxiety measures.…”

Section: Mental Health In Patients With Noninfectious Uveitismentioning

confidence: 99%

Anxiety and depression in patients with uveitis: a comprehensive review of observational studies

Choo,

Gonzales,

Shantha

2023

Current Opinion in Ophthalmology

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Purpose of the review The purpose of this review is to provide a comprehensive summary of observational studies evaluating anxiety and depression in patients with uveitis. Recent findings A higher prevalence of depression was reported in patients with uveitis compared to healthy controls in most observational studies. Symptoms of anxiety were often, but not always, significantly worse in patients with uveitis compared to controls. Most studies found that patients with uveitis had reduced vision-related quality of life that was associated with anxiety and depression symptoms. Summary Patients with uveitis have a higher risk of experiencing symptoms of depression and could benefit from screening and treatment. Preliminary screening for vision-related quality of life could also help determine if the patient requires assistance in mental health or other aspects of daily living.

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“…No significant difference between BD with major depression and healthy controls (Beck et al, 1961) Increased severity of depression Can Sandikci et al (2019) Cross-sectional BD Hospital Anxiety and Depression Scale (Zigmond & Snaith, 1983) No significant difference between BD and controls Zulfiqar et al (2020) Longitudinal BD Patient Health Questionnaire-9 (Kroenke et al, 2001) Weak correlation with disease activity Strong correlation with patient and clinician perception Atay and Erturan (2020) Case-control BD versus healthy individuals Beck depression inventory (Beck et al, 1961) Passive coping styles increase depressive symptoms Disease duration is also related to depressive symptomatology…”

Section: Significantly Higher Depression Scores In Bd Patientsmentioning

confidence: 99%

“…The data regarding the association between depression and disease activity is still contradictive. While certain studies found a strong correlation between depression and greater disease activity (34; 35) or more severe disease manifestations (Gur et al., 2006; Melikoglu & Melikoglu, 2010; Saygin et al., 2015; Ucar et al., 2017), others found no significant association between depression and disease activity (Can Sandikci et al., 2019; Gunduz et al., 2012; Hayriye Sorgun et al., 2020; Murray et al., 2021; Zulfiqar et al., 2020). Depression can prolong disease duration as well (Atay et al., 2014).…”

Section: Depressionmentioning

confidence: 99%

The psychological impact of Behçet's disease

Hasbani

Uthman

Jawad³

et al. 2022

Musculoskeletal Care

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Background Bechet's disease (BD), a chronic multiorgan involving disease, has a significant impact on quality of life in spite of effective treatment modalities. Disease manifestations such as arthritis, orogenital ulcerations, rashes, angiitis, and neurological involvement affect health‐related quality of life (HRQoL) through its impact on depression, anxiety, and fatigue. Objectives We aimed explore the psychological impact of BD, taking into consideration the effect on the HRQoL, as well as the association with depression, anxiety, wellbeing, and fatigue. Methods This is a narrative review of the literature that looks into the association of BD on the HRQoL including all studies that have assessed such as association. Results/Findings Depression and anxiety are prevalent among patients with BD, and contribute significantly to fatigue, a common symptom among BD patients. In addition, the psychological wellbeing is affected by the disease, however, more studies are needed to assess this relationship. Conclusion Depression and anxiety are strongly associated with BD, and contribute significantly to fatigue, a common symptom among BD patients. In addition, the psychological wellbeing is affected by the disease, however, more studies are needed to assess this relationship. Besides, the controlling factors of the psychological impact are still to be deciphered.

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Longitudinal Study Investigating the Relationship between Disease Activity and Psychological Status of Patients with Behçet’s Disease

Cited by 7 publications

References 26 publications

Number of Episodes Can Be Used as a Disease Activity Measure in Familial Mediterranean Fever

Number of Episodes Can Be Used as a Disease Activity Measure in Familial Mediterranean Fever

Anxiety and depression in patients with uveitis: a comprehensive review of observational studies

The psychological impact of Behçet's disease

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