Longitudinal Studies of Renal Biopsies1

Pirani, C L; Pollak, Victor E.

doi:10.1159/000390028

Cited by 5 publications

(6 citation statements)

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“…Our results support the view that PGN is a proliferative glomerular disease [33,38,43], even if the proliferation is small and can easily be overlooked. This may account for the failure of some investigators to observe a prolife ration of this disease [10,14,15,21.22,26,28,30,36,40].…”

Section: Discussionsupporting

confidence: 90%

“…Therapy is usually ineffective in development of the morphological lesions of PGN [11,29], whereas the clinical course of PGN is generally more favor able than the morphological course [22,38,40]. Confirming this, our serial biopsies indicate the morphological lesion is often unchanged or deteriorated, even during prolonged complete clinical remission.…”

Section: Discussionsupporting

confidence: 74%

“…Firstly, PGN is primarily a disease of middle age [4.19, 21-23,38,43], but it also occurs in children [14,21,27]. Secondly, PGN occurs more often in males than in females [19,21,37,43], Thirdly, PGN manifests in a small part of cases after viral and bacterial infections of the respiratory tract [19,21], Streptococcus infections probably play a minor role [21,26,37,38], because in most of our patients tonsillitis were reported to have occurred often many years prior to the onset of the renal disease. In addition the ASO titers were within normal limits in 90% of our patients.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Clinical and Morphological Features of Peri- (Epi-Extra) Membranous Glomerulonephritis

Fischbach

Wehner

et al. 1974

Nephron

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The following conelusions can be drawn from this study of the clinical and morphological features of perimembranous glomerulonephritis (PGN) in 100 patients and in 31 patients who had serial renal biopsies: (1) PGN appears in every age group and is especially frequent between 31–40 and 51–60 years; it occurs more often in males than in females; (2) PGN begins in most cases idiopathically without preceding diseases; (3) the predominant early symptoms of PGN are edema and/or proteinuria; (4) the nephrotic syndrome is the most striking symptom when PGN is fully developed; (5) Hypertension is frequently observed in patients with PGN; the combination of the nephrotic syndrome and hypertension is observed more frequently than the nephrotic syndrome and normal blood pressure; the combination of hypertension, hematuria and the nephrotic syndrome is also frequently observed; (6) proteinuria is most marked in the early stages of PGN and decreases as the transformations of the glomerular basement membrane progress; (7) PGN is a proliferative glomerular disease, but the proliferation is mild and may only be a proliferation of the mesangial cells; (8) the prognosis of PGN is unfavorable; clinical improvement can occur without an improvement in the morphological features of the glomerular basement membrane.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of Clinical and Morphological Features of Peri- (Epi-Extra) Membranous Glomerulonephritis

Fischbach

Wehner

et al. 1974

Nephron

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show abstract

“…They called it 'latent glomerulonephritis' (Bell, 1946), 'defective healing' (Addis, 1948), 'latent phase' (Pirani & Pollak, 1967), 'dormant glomerulonephritis' (Kimmelstiel, Osawa & Beres, 1967), 'symptomatic glomerulonephritis' (Takatsu & Sato, 1962) or 'focal sclerosing glomerulonephritis' (McGovern, 1967). We prefer the name 'minimal glomerular scar formation'.…”

Section: Minimal Scar Formationmentioning

confidence: 99%

“…The best results occur with minimal scar formation as has been shown recently by Cameron (1968) (see also Drummond et al, 1966;Royer et al, 1967). Forms with acute proliferative and membranous glomerulonephritis on the other hand are thought to be steroid-resistant (Pirani & Pollak, 1967;Ross, 1967, and others). Immunosuppressive therapy gives good results, if large deposits with positive immunofluorescence are present (Michael, 1967;Dixon, 1967) and at least may improve those with active proliferation (Vernier et al, 1967).…”

Section: Circulatory Disturbancesmentioning

confidence: 99%