Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative

Dannhauer, T.; Sattler, M.; Wirth, W.; Hunter, David J.; Kwoh, C. Kent; Eckstein, F.

doi:10.1007/s10334-013-0418-z

Cited by 33 publications

(43 citation statements)

References 45 publications

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“…These changes were slightly smaller than those observed in a convenience sample of RKOA (−2.1%) and no-RKOA knees (−1.5%) (14). They also were smaller than those in limbs with JSN knees (−1.1%) (3) and in limbs with progressive knee OA (−2.8%) or matched RKOA knees without structural progression (−1.8%) (13), with the same measurement methodology used in the current and in the latter studies (3;13). …”

Section: Discussionmentioning

confidence: 50%

“…Our analysis of two-year changes in muscle status was confined to differences in muscle ACSAs, as these are more sensitive to change than those in muscle strength (13). The two-year changes in quadriceps ACSA were small, and although they appeared greater in early RKOA knees than in contralateral no-RKOA knees (−0.9 vs. −0.5%), the between-person variability was relatively large and the difference did not attain statistical significance.…”

Section: Discussionmentioning

confidence: 99%

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Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison

Ruhdorfer

Dannhauer

Wirth

et al. 2014

Osteoarthritis and Cartilage

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Objective To compare cross-sectional and longitudinal side-differences in thigh muscle anatomical cross-sectional areas (ACSAs), muscle strength, and specific strength (strength/ACSA), between knees with early radiographic change vs. knees without radiographic knee osteoarthritis (RKOA), in the same person. Design 55 (of 4796) Osteoarthritis Initiative participants fulfilled the inclusion criteria of early RKOA in one limb (definite tibiofemoral osteophytes; no radiographic joint space narrowing [JSN]) vs. no RKOA (no osteophyte; no JSN) in the contralateral limb. ACSAs of the thigh muscles and quadriceps heads were determined using axial MRIs at 33%/30% femoral length (distal to proximal). Isometric extensor and flexor muscle strength were measured (Good Strength Chair). Baseline quadriceps ACSA and extensor (specific) strength represented the primary analytic focus, and two-year changes of quadriceps ACSAs the secondary focus. Results No statistically significant side-differences in quadriceps (or other thigh muscle) ACSAs, muscle strength, or specific strength were observed between early RKOA vs. contralateral limbs without RKOA (p≥0.44), neither in men nor in women. The two-year reduction in quadriceps ACSA in limbs with early RKOA was −0.9±6% (mean ± standard deviation) vs. −0.5±6% in limbs without RKOA (statistical difference p=0.85). Conclusion Our results do not provide evidence that early unilateral radiographic changes, i.e. presence of osteophytes, are associated with cross-sectional or longitudinal differences in quadriceps muscle status compared with contralateral knees without RKOA. At the stage of early unilateral RKOA there thus appears to be no clinical need for countervailing a potential dys-balance in quadriceps ACSAs and strength between both knees.

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Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 99%

Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison

Ruhdorfer

Dannhauer

Wirth

et al. 2014

Osteoarthritis and Cartilage

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“…Two-year rates of change in quadriceps CSAs were similar in participants with and without radiographic OA,121 and in knees with and without radiographic JSN 124. However, OA knees with longitudinal JSW and cartilage loss above a defined threshold (structural progressors) displayed greater concurrent quadriceps CSA loss (−2.8±7.9%) than matched, non-progressive controls (−1.8±6.8%); further change in CSAs was less variable than that in muscle strength 125. One study126 reported significant differences of thigh intermuscular fat volume between women with and without ROA, not paralleled by differences in muscle; thigh intermuscular fat explained as much of the variability in physical knee function as radiographic status 126…”

Section: Imaging Publications From Full Cohort Releasesmentioning

confidence: 79%

Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment

Eckstein

Kwoh

Link³

2014

Ann Rheum Dis

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The Osteoarthritis Initiative (OAI) is a multicentre, prospective, observational, cohort study of knee osteoarthritis (OA) that began recruitment in 2004. The OAI provides public access to clinical and image data, enabling researchers to examine risk factors/predictors and the natural history of knee OA incidence and progression, and the qualification of imaging and other biomarkers. In this narrative review, we report imaging findings and lessons learned 10 years after enrolment has started. A literature search for full text articles published from the OAI was performed up to 31 December 2013 using Pubmed and the OAI web page. We summarise the rationale, design and imaging protocol of the OAI, and the history of OAI publications. We review studies from early partial, and later full OAI public data releases. The latter are structured by imaging method and tissue, reviewing radiography and then MRI findings on cartilage morphology, cartilage lesions and composition (T2), bone, meniscus, muscle and adipose tissue. Finally, analyses directly comparing findings from MRI and radiography are summarised. Ten years after the first participants were enrolled and first papers published, the OAI has become an invaluable resource to the OA research community. It has fuelled novel methodological approaches of analysing images, and has provided a wealth of information on OA pathophysiology. Continued collection and public release of long-term observations will help imaging measures to gain scientific and regulatory acceptance as 'prognostic' or 'efficacy of intervention' biomarkers, potentially enabling shorter and more efficient clinical trials that can test structure-modifying therapeutic interventions (NCT00080171).

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“…Greater reduction in quadriceps cross-sectional area over 2 years was observed in those with structurally progressive knee OA relative to non-progressive controls 39 . Quadriceps cross-sectional area reduced and intermuscular fat increased over 4 years, but these changes were not associated with chronic knee pain 40 .…”

Section: Size and Fat Mattermentioning

confidence: 98%

Osteoarthritis year in review 2015: imaging

Wang

Teichtahl

Cicuttini

2016

Osteoarthritis and Cartilage

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Longitudinal sensitivity to change of MRI-based muscle cross-sectional area versus isometric strength analysis in osteoarthritic knees with and without structural progression: pilot data from the Osteoarthritis Initiative

Abstract: MRI-based analysis of quadriceps muscles ACSAs appears to be more sensitive to longitudinal change than isometric extensor strength and is suggestive of greater loss in limbs with structurally progressive KOA than in non-progressive controls.

Cited by 33 publications

References 45 publications

Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison

Thigh muscle cross-sectional areas and strength in knees with early vs knees without radiographic knee osteoarthritis: a between-knee, within-person comparison

Imaging research results from the Osteoarthritis Initiative (OAI): a review and lessons learned 10 years after start of enrolment

Osteoarthritis year in review 2015: imaging

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