Longitudinal Reduction in Diversity of Maternal Gut Microbiota During Pregnancy Is Observed in Multiple Low-Resource Settings: Results From the Women First Trial

Tang, Minghua; Weaver, Nicholas E.; Frank, Daniel N.; Ir, Diana; Robertson, Charles E.; Kemp, Jennifer; Westcott, Jamie E; Shankar, Kartik; Garcés, Ana; Figueroa, Lester; Tshefu, Antoinette; Lokangaka, Adrien; Goudar, Shivaprasad S; Somannavar, Manjunath S; Aziz, Sumera; Saleem, Sarah; McClure, Elizabeth M; Hambidge, K. Michael; Hendricks, Audrey E.; Krebs, Nancy F.

doi:10.3389/fmicb.2022.823757

Cited by 9 publications

(8 citation statements)

References 37 publications

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“…Our observations were consistent with previous evidence, reporting the decreased microbial diversity with advancing gestation. [ 20 , 21 , 22 ] This phenomenon might be due to the metabolic modifications occurred during pregnancy, including increased levels of blood glucose and hormone, which could change the internal environment of the human body. [ 22 , 23 ] In addition, the F/B ratio, a biomarker of gut microbial homeostasis, [ 24 ] showed a different temporal trend among GDM patients compared to controls.…”

Section: Resultsmentioning

confidence: 99%

The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case‐Control Study of Gestational Diabetes Mellitus

et al. 2023

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Though gut microbiome disturbance may be involved in the etiology of gestational diabetes mellitus (GDM), data on the gut microbiome's dynamic change during pregnancy and associations with gestational glucose metabolism are still inadequate. In this prospective study comprising 120 pairs of GDM patients and matched pregnant controls, a decrease in the diversity of gut microbial species and changes in the microbial community composition with advancing gestation are found in controls, while no such trends are observed in GDM patients. Multivariable analysis identifies 10 GDM-related species (e.g., Alistipes putredinis), and the integrated associations of these species with glycemic traits are modified by habitual intake of fiber-rich plant foods. In addition, the microbial metabolic potentials related to fiber fermentation (e.g., mannan degradation pathways) and their key enzymes consistently emerge as associated with both GDM status and glycemic traits. Microbial features especially those involved in fiber fermentation, provide an incremental predictive value in a prediction model with established risk factors of GDM. These data suggest that the gut microbiome remodeling with advancing gestation is different in GDM patients compared with controls, and dietary fiber fermentation contributes to the influence of gut microbiome on gestational glycemic regulation.

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Section: Resultsmentioning

confidence: 99%

The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case‐Control Study of Gestational Diabetes Mellitus

et al. 2023

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“…Concentrations of CRP and AGP fell between enrolment and visit 3, when there were few associations between inflammation and adverse outcomes and comparatively few women had inflammation, and then rose again at delivery. The mechanism underlying these changes are unclear, but similar declines in AGP between the end of the first and second trimester were reported from a study of pregnant women in Pakistan, India and Guatemala who did not receive IPTp [ 28 ] and an increase in CRP in the third trimester (compared to the first) has been previously seen in a pregnant women from Nepal [ 25 ].…”

Section: Discussionmentioning

confidence: 69%

Intermittent preventive treatment with sulphadoxine-pyrimethamine but not dihydroartemisinin-piperaquine modulates the relationship between inflammatory markers and adverse pregnancy outcomes in Malawi

Cheng,

Aitken,

Hasang

et al. 2024

PLOS Glob Public Health

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Women in malaria-endemic areas receive sulphadoxine-pyrimethamine (SP) as Intermittent Preventive Treatment in Pregnancy (IPTp) to reduce malaria. While dihydroartemisinin-piperaquine (DP) has superior antimalarial properties as IPTp, SP is associated with superior fetal growth. As maternal inflammation influences fetal growth, we investigated whether SP alters the relationship between inflammation and birth outcomes. We measured C-reactive protein (CRP) and alpha-1-acid glycoprotein (AGP) at enrollment (16–28 gestation weeks (gw)), visit 3 (24–36 gw) and delivery in 1319 Malawian women randomized to receive monthly SP, DP, or DP and single-dose azithromycin (AZ) in the IMPROVE trial (NCT03208179). Logistic regression was used to assess the relationship between adverse outcomes, inflammation, and treatment arm. Elevated AGP at enrollment was associated with adverse birth outcome (aRR 1.40, 95% CI: 1.15, 1.70), with similar associations observed across treatment arms, exceptions being that elevated AGP was associated with low maternal weight gain in SP recipients (aRR 1.94, 95% CI: 1.36, 2.76) and with small for gestational age in DP+AZ recepients (aRR 1.49, 95% CI 1.02, 2.17). At visit 3 there were few associations between inflammation andoutcomes. At delivery, women with elevated AGP receiving either DP or DP+AZ had an increased risk of adverse birth outcomes (aRR 1.60, 95% CI: 1.28, 2.00), including low birth weight, pre-term birth and foetal loss, this was not seen in women receiving SP (aRR 0.82, 95% CI: 0.54, 1.26). The risk of an association between elevated AGP and adverse birth outcome was higher in those receiving DP or DP+AZ compared to those receiving SP (aRR 1.95, 95% CI: 1.21, 3.13). No clear associations between CRP and adverse outcomes were observed. AGP identified women at risk of adverse pregnancy outcomes. SP modifies the relationship between inflammatory biomarkers and adverse outcomes. Our findings provide insights into potential mechanisms by which SP may improve pregnancy outcomes.

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“…Multiple phenotypes from different categories can also be tied together by a singles species. For instance, uSGB5239 (of the Lachnospiraceae family) is associated with 22 different species from the health category (BMI, Stomach illness, Dementia); the food and animal category (Vegetables, Fruits, Natural juice, Beef/pork, Fish); and the socioeconomic category (Grades>6, Travel, Household wealth index, TV, No electronics, Earth/sand floor, Ceramic floor, Glass windows, Clay/mud walls, Cement walls, and Sleeping rooms) ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

Environmental, Socioeconomic, and Health Factors Associated with Gut Microbiome Species and Strains in Isolated Honduras Villages

Shridhar

Beghini

Alexander

et al. 2023

Preprint

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Despite a growing interest in the gut microbiome of non-industrialized regions of the world, data linking microbiome features from such settings to diverse phenotypes remains uncommon. Here, using metagenomic data from a community-based cohort of 1,187 people from isolated villages in the Mesoamerican highlands of Western Honduras, we report 7,117 statistically robust associations spanning 788 gut microbial species (including both known and unknown taxa) and 126 phenotypes (including physical and mental health, medication use, diet, animal exposure, and social and economic measures). We report 394 new associations with mental health phenotypes alone, as well as 3,004 associations with diverse socioeconomic phenotypes. Distinctly, we also found 1,210 associations with microbiome metabolic pathways. We also report 302 significant associations after including strain-level phylogenies from 666 microbial species. Including the strain-phylogenetic information changes the overall relationship between gut microbiome and these phenotypes, and strain-level phylogenetic information enhances the observed relationship between microbiome and phenotypes as a whole. Our findings suggest new roles that gut microbiome surveillance can play in understanding broad features of individual and public health.

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Longitudinal Reduction in Diversity of Maternal Gut Microbiota During Pregnancy Is Observed in Multiple Low-Resource Settings: Results From the Women First Trial

Cited by 9 publications

References 37 publications

The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case‐Control Study of Gestational Diabetes Mellitus

The Gut Microbiome Dynamically Associates with Host Glucose Metabolism throughout Pregnancy: Longitudinal Findings from a Matched Case‐Control Study of Gestational Diabetes Mellitus

Intermittent preventive treatment with sulphadoxine-pyrimethamine but not dihydroartemisinin-piperaquine modulates the relationship between inflammatory markers and adverse pregnancy outcomes in Malawi

Environmental, Socioeconomic, and Health Factors Associated with Gut Microbiome Species and Strains in Isolated Honduras Villages

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