Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD

Bonne, Omer; Brandes, Dalia; Gilboa, Asaf; Gomori, John M.; Shenton, Martha E.; Pitman, Roger K.; Shalev, Arieh Y.

doi:10.1176/appi.ajp.158.8.1248

Cited by 364 publications

(246 citation statements)

References 27 publications

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“…There is an ongoing debate as to whether this volume reduction is due to an elevated activity of stress-associated neurobiological systems, such as the HPA axis or is genetically determined (Gilbertson et al, 2002). In contrast to the finding of reduced hippocampal volume, all published studies investigating amygdala volumes in patients with PTSD did not find any significant amygdala volume difference compared to controls (Bonne et al, 2001;Bremner et al, 1997;De Bellis et al, 1999;Gilbertson et al, 2002;Gurvits et al, 1996).…”

Section: Volumetrics and Spectroscopymentioning

confidence: 96%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

171

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Neuroimaging has become one of the most important methods in the investigation of the neurobiological underpinnings of borderline personality disorder. Structural and functional imaging studies have revealed dysfunction in different brain regions which seem to contribute to borderline symptomatology. This review presents relevant studies using different methodologies: volumetry of limbic and prefrontal regions, investigations of brain metabolism under resting conditions, studies of serotonergic neurotransmission, and challenge studies using emotional, stressful, and sensory stimuli. Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology.

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Section: Volumetrics and Spectroscopymentioning

confidence: 96%

Neuroimaging in borderline personality disorder

Schmahl¹,

Bremner²

2006

Journal of Psychiatric Research

171

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“…[28][29][30][31] Similarly, several groups found smaller bilateral hippocampi in patients with PTSD, 32,33 whereas others were unable to find significantly smaller hippocampi in PTSD. [34][35][36] In MD, significantly smaller bilateral hippocampal volumes have been reported by some, 11,37,38 but not by others. 39,40 Part of the discrepancy among research findings may be attributed to the use of different methods for establishing hippocampal volume.…”

mentioning

confidence: 88%

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

2004

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The advance of neuroimaging techniques has resulted in a burgeoning of studies reporting abnormalities in brain structure and function in a number of neuropsychiatric disorders. Measurement of hippocampal volume has developed as a useful tool in the study of neuropsychiatric disorders. We reviewed the literature and selected all English-language, human subject, data-driven papers on hippocampal volumetry, yielding a database of 423 records. From this database, the methodology of all original manual tracing protocols were studied. These protocols differed in a number of important factors for accurate hippocampal volume determination including magnetic field strength, the number of slices assessed and the thickness of slices, hippocampal orientation correction, volumetric correction, software used, inter-rater reliability, and anatomical boundaries of the hippocampus. The findings are discussed in relation to optimizing determination of hippocampal volume.

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“…a minimum score on a screening instrument). For example, three studies (Bryant et al, 2012; deRoon-Cassini et al, 2010; Jenewein et al, 2009) had a minimum hospital admission length (24–48 hours), and three studies (Bonne et al, 2001; Shalev et al, 2012; van Zuiden et al, 2017) had a minimum threshold or criterion for initial symptoms. These criteria screened for more severely injured or more symptomatic patients to be included in the studies.…”

Section: Resultsmentioning

confidence: 99%

“…One month of symptom duration is needed to meet the DSM criteria for PTSD. However, some researchers choose to evaluate PTSD symptoms much earlier without necessarily diagnosing owing to the difficulty in reaching individuals after their being discharged from hospital (Bonne et al, 2001; Bryant et al, 2008; Hepp et al, 2008). It is noteworthy to recognize that some PTSD symptoms (e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The International Consortium to Predict PTSD (ICPP) is an effort sponsored by the US National Institute of Mental Health to create a consortium of principal investigators of published and unpublished longitudinal PTSD studies (Bonne et al, 2001; Bryant, Creamer, O’Donnell, Silove, & McFarlane, 2008; deRoon-Cassini, Mancini, Rusch, & Bonanno, 2010; Hepp et al, 2008; Irish et al, 2008; Jenewein, Wittmann, Moergeli, Creutzig, & Schnyder, 2009; Matsuoka et al, 2009a; Mouthaan et al, 2014; Shalev et al, 2012, 2000, 2008; van Zuiden et al, 2017), combine their individual- and item-level data towards carrying out a pooled secondary analysis, and synthesize information about the predictors of PTSD. The ICPP’s goal is to pool and harmonize extant data sets so as to inform PTSD pathogenesis and prediction across trauma types, severity, geography, and clinical circumstances.…”

Section: Introductionmentioning

confidence: 99%

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Application of data pooling to longitudinal studies of early post-traumatic stress disorder (PTSD): the International Consortium to Predict PTSD (ICPP) project

Ratanatharathorn

Gevonden

et al. 2018

European Journal of Psychotraumatology

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Background: Understanding the development of post-traumatic stress disorder (PTSD) is a precondition for efficient risk assessment and prevention planning. Studies to date have been site and sample specific. Towards developing generalizable models of PTSD development and prediction, the International Consortium to Predict PTSD (ICPP) compiled data from 13 longitudinal, acute-care based PTSD studies performed in six different countries.Objective: The objectives of this study were to describe the ICPP’s approach to data pooling and harmonization, and present cross-study descriptive results informing the longitudinal course of PTSD after acute trauma.Methods: Item-level data from 13 longitudinal studies of adult civilian trauma survivors were collected. Constructs (e.g. PTSD, depression), measures (questions or scales), and time variables (days from trauma) were identified and harmonized, and those with inconsistent coding (e.g. education, lifetime trauma exposure) were recoded. Administered in 11 studies, the Clinician Administered PTSD Scale (CAPS) emerged as the main measure of PTSD diagnosis and severity.Results: The pooled data set included 6254 subjects (39.9% female). Studies’ average retention rate was 87.0% (range 49.1–93.5%). Participants’ baseline assessments took place within 2 months of trauma exposure. Follow-up durations ranged from 188 to 1110 days. Reflecting studies’ inclusion criteria, the prevalence of baseline PTSD differed significantly between studies (range 3.1–61.6%), and similar differences were observed in subsequent assessments (4.3–38.2% and 3.8–27.0% for second and third assessments, respectively).Conclusion: Pooling data from independently collected studies requires careful curation of individual data sets for extracting and optimizing informative commonalities. However, it is an important step towards developing robust and generalizable prediction models for PTSD and can exceed findings of single studies. The large differences in prevalence of PTSD longitudinally cautions against using any individual study to infer trauma outcome. The multiplicity of instruments used in individual studies emphasizes the need for common data elements in future studies.

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Longitudinal MRI Study of Hippocampal Volume in Trauma Survivors With PTSD

Abstract: Smaller hippocampal volume is not a necessary risk factor for developing PTSD and does not occur within 6 months of expressing the disorder. This brain abnormality might occur in individuals with chronic or complicated PTSD.

Cited by 364 publications

References 27 publications

Neuroimaging in borderline personality disorder

Neuroimaging in borderline personality disorder

MR-based in vivo hippocampal volumetrics: 1. Review of methodologies currently employed

Application of data pooling to longitudinal studies of early post-traumatic stress disorder (PTSD): the International Consortium to Predict PTSD (ICPP) project

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