Longitudinal Microperimetry Evaluation After Intravitreal Ocriplasmin Injection for Vitreomacular Traction

Abstract

Microperimetry demonstrates a significant gain in retinal sensitivity, particularly in the central 4° area, in eyes with anatomic resolution after treatment of vitreomacular traction with intravitreal ocriplasmin injection, even when no significant gain in BCVA is seen.

Microperimetry in Retinal Diseases

“…In these cases, associations between retinal function and treatment outcomes have been found, suggesting that MP can be useful in assessing baseline retinal sensitivity and functional change over time. A longitudinal cohort study by Cacciamani et al121 examined 16 eyes with symptomatic VMT using the MP-1 microperimeter to investigate whether improvements in macular function were associated with anatomic resolution after ocriplasmin treatment (125 µg intravitreal injection). Significant increases in mean retinal sensitivity (within central 4 degrees) of ~3.7 dB were seen in those with resolved VMA following treatment, whereas no measurable changes in retinal function were seen in those with unresolved VMA.…”

The Oasis Mp-1 Substudy

“…Several studies have been published, examining a range of 2 to 16 eyes with VMA, with few microperimetry parameters assessed. 14–16 In the largest of these studies to date (n = 16), a significant gain in retinal sensitivity was seen in eyes with anatomical resolution after treatment with intravitreal ocriplasmin injection. 16 Unlike diseases that permanently degenerate the macula, VMA can be successfully treated through surgical or pharmacological intervention, 1 which increases the need for comprehensive assessment through microperimetry both before and after VMA resolution.…”