Short-term changes in posterior vitreous cortex following intravitreal ocriplasmin for symptomatic vitreomacular traction syndrome: a prospective study

Cacciamani, Andrea; Gattegna, Roberto; Pileri, Marco; Nicola, Marta Di; Bardanzellu, S.; Facciolo, Giuliana; Cosimi, Pamela; Govetto, Andrea; Scarinci, Fabio

doi:10.1007/s10792-019-01177-7

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Int Ophthalmol

2019

DOI: 10.1007/s10792-019-01177-7

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Short-term changes in posterior vitreous cortex following intravitreal ocriplasmin for symptomatic vitreomacular traction syndrome: a prospective study

Andrea Cacciamani

Roberto Gattegna

Marco Pileri

et al.

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2023

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Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes

Quiroz-Gonzalez

Lima-Gómez

2023

Int J Retin Vitr

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Background We conducted a systematic review to compare the effects of pneumatic vitreolysis (PV), enzymatic vitreolysis (EVL) with ocriplasmin, and pars plana vitrectomy (PPV) on vitreomacular traction (VMT) syndrome and macular holes (MHs) to assess their efficacy as treatment options. Methods Databases, including PubMed, ClinicalTrials.gov (www.clinicaltrials.gov), the Cochrane Central Register of Controlled Trials (CENTRAL)—including the Cochrane Eyes and Vision Group Trials Register (The Cochrane Library 2013, Issue 2)—, Ovid MEDLINE, and EMBASE (January 2000–October 2022), were searched to identify studies comparing the outcomes of PV versus PPV, PPV versus ocriplasmin and ocriplasmin versus PV. RevMan 5.1 was used for the meta-analysis of the studies. Results Among the 89 studies, 79 were considered eligible for qualitative analysis, and 10 quantitative studies were subjected to meta-analysis. PPV resulted in better postoperative visual acuity improvement than ocriplasmin (standardized mean deviation (SMD) = 0.38, 95% CI 0.03–0.73, p = 0.0003). PV resulted in no significant difference in visual improvement compared with PPV (SMD = − 0.15, 95% CI − 0.47 to 0.16, p = 0.35). PPV was significantly more effective in terms of the VMT release rate (risk ratio = 0.48, 95% CI 0.38–0.62, p = 0.00001) and MH closure rate (risk ratio = 0.49, 95% CI 0.30–0.81, p = 0.006) than ocriplasmin. PV was more effective than ocriplasmin in terms of the VMT release rate (risk ratio = 0.49, 95% CI 0.35–0.70, p = 0.0001). Qualitative analysis showed MH closure rates of 46%, 47.8%, and 95% and VMT releases rates of 46%, 68% and 100% after ocriplasmin, PV, and PPV treatments, respectively. Adverse events and postoperative complications occurring after treatment have also been documented in these studies. Conclusion PPV appears to be the most promising option for MH closure and VMT release, with fewer serious complications than EVL or PV. However, given the limited number of studies comparing these treatments, further research is needed to establish the superiority of PPV over the other options.

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Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes

Quiroz-Gonzalez

Lima-Gómez

2023

Int J Retin Vitr

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Short-term changes in posterior vitreous cortex following intravitreal ocriplasmin for symptomatic vitreomacular traction syndrome: a prospective study

Cited by 1 publication

References 19 publications

Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes

Pneumatic vitreolysis versus vitrectomy for the treatment of vitreomacular traction syndrome and macular holes: complication analysis and systematic review with meta-analysis of functional outcomes

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