“…Such approaches include registration of multiple time points to a particular reference image (Avants et al, 2007;Skrinjar, Bistoquet, & Tagare, 2008), often defined as an evolving within-subject average (Ashburner & Ridgway, 2013;Reuter, Schmansky, Rosas, & Fischl, 2012;Rohrer et al, 2013); spatiotemporal registration, with temporal regularization of transformations ; spatiotemporal or '4-D' segmentation and/or surface modeling of the registered time series (Cardoso, Clarkson, Modat, & Ourselin, 2011;Nakamura, Fox, & Fisher, 2011;Reuter et al, 2012;Wolz et al, 2010); concatenation of longitudinal registration and longitudinal segmentation steps (Aubert-Broche et al, 2012); and simultaneous combined registration and segmentation of the set of images, often constraining or regularizing the temporal changes (Gilmore et al, 2012;Prastawa, Awate, & Gerig, 2012;Xue, Shen, & Davatzikos, 2006). Such approaches include registration of multiple time points to a particular reference image (Avants et al, 2007;Skrinjar, Bistoquet, & Tagare, 2008), often defined as an evolving within-subject average (Ashburner & Ridgway, 2013;Reuter, Schmansky, Rosas, & Fischl, 2012;Rohrer et al, 2013); spatiotemporal registration, with temporal regularization of transformations ; spatiotemporal or '4-D' segmentation and/or surface modeling of the registered time series (Cardoso, Clarkson, Modat, & Ourselin, 2011;Nakamura, Fox, & Fisher, 2011;Reuter et al, 2012;Wolz et al, 2010); concatenation of longitudinal registration and longitudinal segmentation steps (Aubert-Broche et al, 2012); and simultaneous combined registration and segmentation of the set of images, often constraining or regularizing the temporal changes (Gilmore et al, 2012;Prastawa, Awate, & Gerig, 2012;Xue, Shen, & Davatzikos, 2006).…”