Longitudinal Changes of Serum Albumin in Elderly People Living in the Community

Shibata, Hiroshi; Haga, Hiroshi; Ueno, Mitsuo; Nagai, Harumi; Yasumura, Seiji; Koyano, Wataru

doi:10.1093/ageing/20.6.417

Cited by 58 publications

(46 citation statements)

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“…However, it is quite difficult to control completely for all potential confounding factors. In addition, in a 10-y longitudinal study, the rate of change in serum albumin did not differ between the groups with and without disease (12). The elderly live individually with various backgrounds, such as disease, physical activity or disability, health condition, and lifestyle.…”

Section: Discussionmentioning

confidence: 86%

Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population

Gomi

Fukushima

Shiraki

et al. 2007

J Nutr Sci Vitaminol

118

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Summary While lower serum albumin concentration is often found in the elderly, a relation between serum albumin and age has not been fully elucidated. We conducted population-based cross-sectional and 5-y longitudinal study to examine the relation. A total of 22,705 male and 40,149 female, aged 65 y and older, living in Gifu, participated in the health check service conducted by Gifu City Medical Association. They were self-supported in the activity of daily living and 3,438 of them were followed up every year from 1999 to 2003. Serum albumin levels decreased with age in both men and women. In the cross-sectional study, median value declined from 4.3 g/dL in males aged 65-69 y to 3.9 g/dL in 90 Ͻ Ϫ y, and 4.3 g/dL to 4.0 g/dL in females. Incidence of hypoalbuminemia (serum albumin Ͻ Ϫ 3.5 g/dL) increased in parallel with age from 1.2% (65-69 y) to 6.6% (85-89) in males, and 0.6% to 4.1% in females. In the longitudinal study, regression analysis showed a significant decline in serum albumin of 0.015 g/dL per year ( r ϭϪ 0.716) in males, and 0.012 g/ dL per year ( r ϭϪ 0.794) in females. Relative reduction of serum albumin in 5 y was larger in advanced age; 1.2% in females aged 65-69 y and 3.1% in 85-89 y ( p Ͻ 0.05), but not in males. In conclusion, a fall in serum albumin concentration in community-dwelling, selfsupported elderly persons was associated significantly with aging.

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Section: Discussionmentioning

confidence: 86%

Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population

Gomi

Fukushima

Shiraki

et al. 2007

J Nutr Sci Vitaminol

118

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“…During that time, epidemiological methods and indicators such as the BMI, serum cholesterol, and serum albumin were developed and improved for their application in epidemiological studies of longevity, as well as that of non inflammatory diseases [17,18]. Both inter-and intra-population studies carried out for the Japanese elderly revealed that poor nutritional status was deleterious for longevity [2,3,5,6,10]. Shibata et al, compared food and nutrient intake in the individuals aged 65 years between Ōgimi Village, Okinawa Prefecture (well-known for the longevity of its residents), Nangai Village and Akita Prefecture (well-known for the extremely short life expectancy of its residents) [6].…”

Section: Discussionmentioning

confidence: 99%

“…Intra-population studies also showed that poor nutritional status, expressed in low BMI, low serum cholesterol and low serum albumin, as well as undesirable food intake, were risk factors for early death [5,6,8,19,20]. Poor nutritional status not only shortens life expectancy but it also deteriorates the functional capacity, cognitive function, and subjective well-being, categorized as quality of life in the elderly [2,21,22].…”

Section: Discussionmentioning

confidence: 99%

“…However, the fact is that Japan has faced malnutrition over the past three decades. The literature has shown the association between nutritional states and longevity, as well as health status, among middle-aged Japanese individuals [5][6][7][8][9][10]. Moreover, the nutritional concerns have been recently raised in younger generations, including children [11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Malnutrition in Japan is Threatening Longevity in the Future

Shibata¹

2017

GGM

Self Cite

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Objective: The average life expectancy in Japan became similar to that in developed Western countries in 1980s. However, the nutritional status of Japanese individuals has continuously deteriorated since. This study evaluated these phenomena using the Japanese time-sequential data and worldwide cross-cultural data.Methods: Japanese trends data of total energy, protein, fat and carbohydrate intake were derived from Japanese National Nutrition Surveys between 1950 and 2014. Total energy intake according to sex and age was also analyzed using these same databases. Trends in average birth weight and the rate of low birth weight (<2,500g) were calculated from Japanese Vital Statistics between 1951 and 2015. A cross-cultural comparison regarding trends of total energy supply (Food Balance Sheets) was made using the 2013 Food and Agriculture Organization (FAO) database between 1992 and 2011. The rates of high (≥30) and low Body Mass Index (BMI) (<18.5) were compared among selected countries based on the WHO Global Database on Body Mass Index (1 November 2016). Results:The total energy intake of Japanese individuals increased until 1970, from which time it decreased progressively. Concordantly, the trend in the decrement of average birth weight and the marked increase of low birth weight (<2,500g) were observed since 1975. The total energy intake remained unchanged only among individuals aged ≥70 years, although it declined in other age groups over the past two decades. The total energy supply between 1992 and 2011 more or less increased worldwide. However, it declined only in Japan. Cross-cultural data revealed that there was a low proportion of Japanese individuals with high BMI (≥30) and a high rate with low BMI (<18.5) as commonly found in developing countries. Conclusion:The present Japanese longevity is a result of the low age-adjusted mortality among individuals aged ≥70 years. The optimistic perspective for longevity in the future should be viewed taking into consideration the deleterious effect on nutritional status in younger generations and low birth weight.

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“…Over the past forty years, it has been developed as a residential area for commuters into the center of Tokyo, and for the retired. Koganei City was chosen by TMIG as the study area as one of the urban communities for search into healthy aging for more than fifteen years [2,3,4]. According to the population data of June 1991, the city had 103,672 persons in an area of 16km ~.…”

Section: Methodsmentioning

confidence: 99%

Vertebral bone mineral density of the elderly in the urban community by mobile DXA

et al. 1994

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Abstract:The present paper describes a population survey of bone mineral density (BMD) on the third lumbar vertebra (L3) using dual X-ray absorptiometry fixed in a van (mobile DXA) with lateral projection. Subjects were 387 persons aged 65 to 84 years living in Koganei City, a western suburb of Tokyo. This is the baseline survey of the 10-year project "Longitudinal Interdisciplinary Study on Aging" supported by Tokyo Metropolitan Institute of Gerontology (TMIG-LISA). As for the pattern of age-related BMD calculated in the range-of-interest (ROI) being set in the center of vertebral body to eliminate the posterior segment of vertebra and/or secondary hyperostotic changes with aging, the mean BMD of L3 declined in females from 0.514+-0.121g/cm ~ (mean _+ standard deviation) in age-group 65-69 to 0.377+--0.137 g/cm 2 in age-group 80-84. In males, it showed a decrease from 0.731--+0.155 in 65-69 to 0.613--+0.158 in 75-79 hut a slight (insignificant) increase at age-group 80-84. There were significant differences of mean BMD between males and females in each age-group and in average. BMD was significantly associated with age (negatively) and body mass index (positively) in the multiple regression analysis.

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Longitudinal Changes of Serum Albumin in Elderly People Living in the Community

Cited by 58 publications

References 0 publications

Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population

Relationship between Serum Albumin Level and Aging in Community-Dwelling Self-Supported Elderly Population

Malnutrition in Japan is Threatening Longevity in the Future

Vertebral bone mineral density of the elderly in the urban community by mobile DXA

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