Longitudinal Changes in Aerobic Capacity: Implications for Concepts of Aging

Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism

“…[1][2][3][4][5][6][7][8][9][10] As a consequence, dramatic reductions in oxygen consumption occur, shifting the entire body toward glycolytic metabolism or aerobic glycolysis [11][12][13] (Fig. 1).…”

Should we use gait speed in COPD, FEV1in frailty and dyspnoea in both?

“…Measurement of grip strength for the determination of muscle mass and waist circumference for determining abdominal obesity could contribute to the interpretation of the results of pulmonary function tests. In this group, levels of lipoprotein(a), a lipid parameter independently associated with CVD, are not associated with the increased CVD risk in people with reduced lung function [52], Due to the strong and consistent association with mortality, pulmonary function has been viewed as a biomarker of ageing [53]. Lung function in individuals with exceptional longevity has been associated with rare genetic variants underlying the linkage peak in chromosome 6 for FEV1 [54].…”

Exercise Performance Is a Prognostic Indicator in Elderly Patients With Chronic Heart Failure – Application of Metabolic Exercise Cardiac Kidney Indexes Score –

“…The clinical characteristics of the whole group and according to age quartile are listed in (1) 23 (2) 32 (3) 57 (6) Other 242 (6) 63 (9) 47 (5) 57 (5) 75 (8) AF 598 (16) 60 (8) 106 (11) 197 (18) 235 (24) <0.0001 PM 721 (19) 97 (13) 149 (15) 205 (19) 270 (28) <0.0001 ICD 952 (25) 177 (25) 254 (26) 280 (26) 241 (25) 0.8178 CRT 367 (10) 61 (9) 94 (10) 99 (10) 113 (12) 0.1584 Table 4). In the Cox models for age quartiles, MECKI score had similar HR, showing that its prognostic power was similar across the age classes (P for interaction=0.734; Table 5).…”