Conflito de interesses: NãoAbstract Introduction: Chronic kidney disease (CKD) is a worldwide public health problem because it presents a high mortality rate, mainly due to cardiovascular complications. Objective: Assess the impact on quality of life and sleep in chronic renal patients with hypertension undergoing hemodialysis and those who reported chest pain. Patients and Methods: This is a descriptive, exploratory, and cross-sectional study, which involved 46 patients with chronic kidney disease and cardiovascular disease, who reported chest pain during the hemodialysis treatment. The World Health Organization Quality of Life-BREF questionnaire was used to assess the quality of life and the Pittsburg Sleep Quality Index were applied to asses sleep quality. In order to evaluate pain, we used the McGill Pain Questionnaire and the Brief Pain Inventory. We used statistical analysis with 5% significance level to analyze data. Results: Among the patients, there were more men (67.4%), mean age of 61.9 ± 15.8 years. The most prevalent type of pain was sensitive pain (24.5%). Impairment on the sleep quality was observed. There was evidence of impairment in quality of life, showing lower scores in physical and psychological domains, and moderate pain intensity. Conclusion: Factors such as pain, sleep, and quality of life are important aspects of people with severe and disabling diseases, which undergo prolonged and painful treatments, so they should be systematically evaluated.