Longitudinal Association Between Hearing Loss, Vision Loss, Dual Sensory Loss, and Cognitive Decline

Ge, Shaokui; McConnell, Eleanor S.; Wu, Bei; Pan, Wei; Dong, Xin Qi; Plassman, Brenda L.

doi:10.1111/jgs.16933

Cited by 31 publications

(33 citation statements)

References 52 publications

(92 reference statements)

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“…In truth, hearing loss can significantly affect the trajectory of healthy aging through precipitating physical and mental health outcomes, such as falls and disabilities, frailty, loneliness, depression, social isolation, and beyond (7)(8)(9)(10)(11)(12)(13). In particular, emerging evidence indicates a connection between ARHI and higher risk of cognitive decline in older people (14)(15)(16)(17)(18)(19), and hearing loss has markedly been acknowledged as a major modifiable risk factor for dementia and Alzheimer's Disease (AD) (20).…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, we analyzed the core data from the 2016 Health and Retirement Study (HRS) (36). Although prior studies were carried out regarding the hearing-cognition association with the HRS cohort (16,19,37), few of them provided outcome data disaggregated by sex or gender. Our aim was to investigate how gender-related characteristics affect the hearing-cognition association in the older demographic alongside biological sex.…”

Section: Introductionmentioning

confidence: 99%

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Gender Modifies the Association of Cognition With Age-Related Hearing Impairment in the Health and Retirement Study

Yuan

Sang

Pham

et al. 2021

Front. Public Health

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Introduction: Despite growing recognition of hearing loss as a risk factor for late life cognitive disorders, sex and gender analysis of this association has been limited. Elucidating this is one means to advocate for holistic medicine by considering the psychosocial attributes of people. With a composite Gender Score (GS), we aimed to assess this among aging participants (50+) from the 2016 Health and Retirement Study (HRS) cohort.Methods: The GS was derived from gender-related variables in HRS by factor analyses and logistic regression, ranging from 0 (toward masculinity) to 100 (toward femininity). GS tertiles were also used to indicate three gender types (GS tertile 1: lower GS indicates masculinity; GS tertile 2: middle GS indicates androgyny; GS tertile 3: higher GS indicates femininity). Univariate followed by multiple logistic regressions were used to estimate the Odds Ratio (OR) and 95% confidence intervals (CI) of cognitive impairment (assessed by adapted Telephone Interview for Cognitive Status) from hearing acuity, as well as to explore the interactions of sex and gender with hearing acuity. The risk of cognitive impairment among hearing-impaired participants was assessed using multivariable models including sex and gender as exposure variables.Results: Five variables (taking risks, loneliness, housework, drinking, and depression) were retained to compute the GS for each participant. The distribution of GS between sexes partly overlapped. After adjusting for confounding factors, the OR for cognitive impairment associated with hearing impairment was significantly higher (OR = 1.65, 95% CI: 1.26, 2.15), and this association was not modified by female sex (OR = 0.77, 95% CI: 0.46, 1.27), but by androgynous gender (OR = 0.44, 95% CI: 0.24, 0.81). In the multivariable models for participants with hearing impairment, androgynous and feminine gender, as opposed to female sex, was associated with lower odds of cognitive impairment (OR of GS tertile 2 = 0.59, 95% CI: 0.41, 0.84; OR of GS tertile 3 = 0.60, 95% CI: 0.41, 0.87; OR of female sex = 0.78, 95% CI: 0.57, 1.08).Conclusions: Hearing impairment was associated with cognitive impairment among older people, and this association may be attenuated by a more feminine GS.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gender Modifies the Association of Cognition With Age-Related Hearing Impairment in the Health and Retirement Study

Yuan

Sang

Pham

et al. 2021

Front. Public Health

View full text Add to dashboard Cite

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“…It has been shown that the coincidence of vision and hearing impairment further increases the risk of falls (40). In addition, it leads to restricted daily activity (42) and is associated with increased risk for mild cognitive impairment (43) and faster cognitive decline (44).…”

Section: Discussionmentioning

confidence: 99%

Impact of Common Dizziness Associated Symptoms on Dizziness Handicap in Older Adults

et al. 2021

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Background: A cross-sectional observational study was designed to determine the impact of dizziness associated symptoms on the dizziness handicap inventory (DHI) in older adults (≥60 years).Methods: In total, 785 individuals referred to a multidisciplinary dizziness unit were assessed. Participants completed self-report questionnaires with general questions about symptoms of dizziness as well as the DHI. The DHI subscores (physical, functional, emotional) were calculated. Medical diagnoses were collected from the medical records of the patients. One-way MANOVA and networking analysis were used to analyze the impact of dizziness associated symptoms on dizziness handicap.Results: Most patients reported swaying dizziness (60.6%) and feeling of unsteadiness (59.8%) with substantial overlap between the types of dizziness. Most frequent dizziness associated symptoms were ear noise/tinnitus, visual problems, and nausea/vomiting. Network analysis revealed that visual disturbances, headache, and hearing impairment were associated with higher DHI and explained 12% of the DHI variance in the linear regression. In the one-way MANOVA visual problems and headache had an effect on all three DHI subscores, while hearing impairment was associated with the functional and emotional subscores of DHI.Conclusion: Distinct dizziness associated symptoms have substantial impact on dizziness handicap in older adults. A multifactorial assessment including these symptoms may assist in tailoring therapies to alleviate dizziness handicap in this group.

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“…A null relationship between VI and cognitive change was also reported in 4 other longitudinal studies. 25,[50][51][52] For example, Hong et al 51 performed a prospective, population-based study of 3,654 participants of the Blue Mountains Eye Study in Australia and reported that VI was not associated with a ≥ 3 point decline in MMSE-Blind scores over 5 years (OR 0.84; 95% CI 0.40-1.79) or 10 years (OR = 1.09; 95% CI 0.52-2.30). This is in contrast to 4 longitudinal studies and one meta-analysis that have found a relationship between VI and cognitive function [12][13][14]53,54 and 1 study that found a relationship between visual acuity, used as a continuous variable, and cognitive decline.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, if sensory loss is thought to cause disuse of the brain leading to atrophy then perhaps people with dual vision and hearing impairments would be at an even higher risk of cognitive decline, as has been indicated in the literature. 25 The Canadian Longitudinal Study on Aging (CLSA) is a large, population-based cohort study with data on over 30,000 middle-aged and older adults. 26 The CLSA used 5 cognitive tests that did not require vision.…”

Section: Introductionmentioning

confidence: 99%

Visual Impairment, Eye Disease, and 3-Year Cognitive Decline: The Canadian Longitudinal Study on Aging

Grant

Aubin

Buhrmann

et al. 2021

Ophthalmic Epidemiology

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Purpose: To examine the longitudinal association between vision-related variables and the 3-year change in cognitive test scores in a community-dwelling sample of adults and to explore whether sex, education, or hearing loss act as effect modifiers. Methods: Data came from two waves of a 3-year population-based prospective cohort study (Canadian Longitudinal Study on Aging), which consisted of 30,097 randomly selected people aged 45-85 years from 7 Canadian provinces. Visual impairment (VI) was defined as binocular presenting visual acuity worse than 20/40. Participants were asked if they had ever had a diagnosis of age-related macular degeneration (AMD), glaucoma, or cataract. Cognitive change over 3 years was examined by calculating the difference between baseline and follow-up scores for the Rey Auditory Verbal Learning Test (RAVLT) and the RAVLT delayed test (memory tests), the Controlled Oral Word Association Test (COWAT) and the Animal Naming Test (ANT) (verbal fluency tests), and the Mental Alternation Test (MAT) (processing speed test). Multiple linear regression was used. Results: VI, AMD, and cataract were not associated with 3-year changes on any of the 5 cognitive tests after adjusting for age, sex, ethnicity, education, income, smoking, diabetes, stroke, heart disease, and province. A report of glaucoma was associated with greater declines in MAT scores (β = -0.60, 95% CI -1.03, -0.18). No effect modification was detected. Conclusions: Glaucoma was associated with worsening processing speed. Further research to confirm this finding and to understand the possible reason is necessary.

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Longitudinal Association Between Hearing Loss, Vision Loss, Dual Sensory Loss, and Cognitive Decline

Cited by 31 publications

References 52 publications

Gender Modifies the Association of Cognition With Age-Related Hearing Impairment in the Health and Retirement Study

Gender Modifies the Association of Cognition With Age-Related Hearing Impairment in the Health and Retirement Study

Impact of Common Dizziness Associated Symptoms on Dizziness Handicap in Older Adults

Visual Impairment, Eye Disease, and 3-Year Cognitive Decline: The Canadian Longitudinal Study on Aging

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