Longitudinal Assessment of Physical Activity, Fitness, Body Composition, Immunological Biomarkers, and Psychological Parameters During the First Year After Diagnosis in Women With Non-Metastatic Breast Cancer: The BEGYN Study Protocol

Zemlin, Cosima; Stuhlert, Caroline; Schleicher, Julia Theresa; Wörmann, Carolin; Altmayer, Laura; Lang, Marina; Scherer, Laura-Sophie; Thul, Ida Clara; Müller, Carolin; Kaiser, Elisabeth; Stutz, Regine; Goedicke-Fritz, Sybelle; Ketter, Laura; Zemlin, Michael; Wagenpfeil, Gudrun; Steffgen, Georges; Solomayer, Erich‐Franz

doi:10.3389/fonc.2021.762709

Cited by 9 publications

(8 citation statements)

References 99 publications

(106 reference statements)

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“…A total of 110 non-metastatic breast cancer patients participated in the BEGYN study between September 2019 and January 2021 [ 23 ]. The median patients’ age was 54 years (range 26–81).…”

Section: Resultsmentioning

confidence: 99%

“…Supplementation of vitamins and trace elements was documented, and patients received a questionnaire about sun exposure and nutrition. Data were collected as described previously in the BEGYN study protocol [ 23 ]. Clinical characteristics (e.g., age, BMI, Karnofsky performance status scale) and histopathological parameters (e.g., TNM classification using the UICC 8th Edition [ 24 ], Grading: Elston and Ellis 1991 [ 25 ], Immunohistochemistry for determination of estrogen receptor (ER), progesterone receptor (PR), Her2 and Ki67 [ 21 , 26 ]) were documented.…”

Section: Methodsmentioning

confidence: 99%

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Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

et al. 2023

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(1) Background: Vitamin D plays an important role in many types of cancer. It was the aim of this study to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients, and the association with prognostic and lifestyle factors. (2) Methods: 110 non-metastatic breast cancer patients were included in the prospective observational “BEGYN” study at Saarland University Medical Center between September 2019 and January 2021. At the initiation visit, serum 25(OH)D levels were measured. Clinicopathological data on prognosis, nutrition, and lifestyle were extracted from data files and obtained using a questionnaire. (3) Results: Median serum 25(OH)D in breast cancer patients was 24 ng/mL (range 5–65 ng/mL), with 64.8% of patients being vitamin D deficient. 25(OH)D was higher among patients that reported the use of vitamin D supplements (43 ng/mL versus 22 ng/mL; p < 0.001), and in summer compared to other seasons (p = 0.03). Patients with moderate vitamin D deficiency were less likely to have triple negative breast cancer (p = 0.047). (4) Conclusions: Routinely measured vitamin D deficiency is common in breast cancer patients and needs to be detected and treated. However, our results do not support the hypothesis that vitamin D deficiency may be a main prognostic factor for breast cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

et al. 2023

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“…These results suggest that research protocols need not instruct participants to remove the sensors during sleep, which may improve participant adherence to wearing the devices [ 15 ]. Some research protocols also instruct participants to record their activities while wearing the sensor(s) [ 55 ]. If sleep is not a behavior of interest in a research study using accelerometry to measure upper limb movement, there is likely no need to burden participants with recording sleep activity.…”

Section: Discussionmentioning

confidence: 99%

Quantifying the effects of sleep on sensor-derived variables from upper limb accelerometry in people with and without upper limb impairment

Miller,

Lang,

Bland

et al. 2024

J NeuroEngineering Rehabil

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Background Despite the promise of wearable sensors for both rehabilitation research and clinical care, these technologies pose significant burden on data collectors and analysts. Investigations of factors that may influence the wearable sensor data processing pipeline are needed to support continued use of these technologies in rehabilitation research and integration into clinical care settings. The purpose of this study was to investigate the effect of one such factor, sleep, on sensor-derived variables from upper limb accelerometry in people with and without upper limb impairment and across a two-day wearing period. Methods This was a secondary analysis of data collected during a prospective, longitudinal cohort study (n = 127 individuals, 62 with upper limb impairment and 65 without). Participants wore a wearable sensor on each wrist for 48 h. Five upper limb sensor variables were calculated over the full wear period (sleep included) and with sleep time removed (sleep excluded): preferred time, non-preferred time, use ratio, non-preferred magnitude and its standard deviation. Linear mixed effects regression was used to quantify the effect of sleep on each sensor variable and determine if the effect differed between people with and without upper limb impairment and across a two-day wearing period. Results There were significant differences between sleep included and excluded for the variables preferred time (p < 0.001), non-preferred time (p < 0.001), and non-preferred magnitude standard deviation (p = 0.001). The effect of sleep was significantly different between people with and without upper limb impairment for one variable, non-preferred magnitude (p = 0.02). The effect of sleep was not substantially different across wearing days for any of the variables. Conclusions Overall, the effects of sleep on sensor-derived variables of upper limb accelerometry are small, similar between people with and without upper limb impairment and across a two-day wearing period, and can likely be ignored in most contexts. Ignoring the effect of sleep would simplify the data processing pipeline, facilitating the use of wearable sensors in both research and clinical practice.

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“…Data on sun exposure, use of sun protection, and avoidance of going outdoors during “sunny hours” were recently published [ 10 ]. Data collection was described in detail previously in the BEGYN study protocol [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

Zemlin,

Altmayer,

Lang

et al. 2024

Nutrients

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(1) Background: Vitamin D levels in patients remain inadequately understood, with research yielding inconsistent findings. Breast cancer patients, particularly due to oncological therapies, face an increased risk of osteopenia, which can be exacerbated by a vitamin D deficiency. (2) Methods: The prospective observational “BEGYN-1” study assessed serum 25(OH)D levels at baseline and quarterly thereafter. Clinical, pathological, nutritional, vitamin supplementation, and lifestyle data were recorded. (3) Results: Before treatment, 68.5% of patients were vitamin D deficient (<30 ng/mL), with 4.6% experiencing severe deficiency (<10 ng/mL). The median baseline 25(OH)D levels were 24 ng/mL (range: 4.8 to 64.7 ng/mL). Throughout the study, the median vitamin D levels increased to 48 ng/mL (range: 22.0 to 76.7 ng/mL). Before diagnosis, 16.7% received vitamin D substitution, and 97.8% received vitamin D substitution throughout the year with a median weekly dose of 20,000 IU. It took at least three quarterly assessments for 95% of patients to reach the normal range. A multiple GEE analysis identified associations between 25(OH)D levels and supplementation, season, age, VLDL, magnesium levels, and endocrine therapy. (4) Conclusions: Physicians should monitor 25(OH)D levels before, during, and after oncological therapy to prevent vitamin D deficiency and to adjust substitution individually. While variables such as seasons, age, VLDL, magnesium, diet, and oncological interventions affect 25(OH)D levels, supplementation has the greatest impact.

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Longitudinal Assessment of Physical Activity, Fitness, Body Composition, Immunological Biomarkers, and Psychological Parameters During the First Year After Diagnosis in Women With Non-Metastatic Breast Cancer: The BEGYN Study Protocol

Cited by 9 publications

References 99 publications

Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

Quantifying the effects of sleep on sensor-derived variables from upper limb accelerometry in people with and without upper limb impairment

Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

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