Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

Zemlin, Cosima; Altmayer, Laura; Stuhlert, Caroline; Schleicher, Julia Theresa; Wörmann, Carolin; Lang, Marina; Scherer, Laura-Sophie; Thul, Ida Clara; Spenner, Lisanne Sophie; Simon, Jana Alisa; Wind, Alina; Kaiser, Elisabeth; Weber, Regine; Goedicke-Fritz, Sybelle; Wagenpfeil, Gudrun; Zemlin, Michael; Solomayer, Erich‐Franz; Reichrath, Jörg; Müller, Carolin

doi:10.3390/nu15061450

Cited by 8 publications

(8 citation statements)

References 48 publications

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“…A total of 19 patients dropped out of the study. Data on tumor biology and tumor entity were previously published [ 10 ]. The median patients’ age was 55 years (min.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the season of assessment should also be considered during regular monitoring. Moreover, we previously demonstrated higher 25(OH)D levels in non-metastatic breast cancer patients who stated that they stayed longer in the sun [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Data on sun exposure and nutrition was achieved using a questionnaire at the baseline visit. Data on sun exposure, use of sun protection, and avoidance of going outdoors during “sunny hours” were recently published [ 10 ]. Data collection was described in detail previously in the BEGYN study protocol [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…Even breast cancer development was linked to 25(OH)D levels in preclinical and animal studies [ 7 , 8 ]. Although, a causal relationship between vitamin D and carcinogenesis in breast cancer patients could not yet be demonstrated in clinical studies [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

Zemlin,

Altmayer,

Lang

et al. 2024

Nutrients

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(1) Background: Vitamin D levels in patients remain inadequately understood, with research yielding inconsistent findings. Breast cancer patients, particularly due to oncological therapies, face an increased risk of osteopenia, which can be exacerbated by a vitamin D deficiency. (2) Methods: The prospective observational “BEGYN-1” study assessed serum 25(OH)D levels at baseline and quarterly thereafter. Clinical, pathological, nutritional, vitamin supplementation, and lifestyle data were recorded. (3) Results: Before treatment, 68.5% of patients were vitamin D deficient (<30 ng/mL), with 4.6% experiencing severe deficiency (<10 ng/mL). The median baseline 25(OH)D levels were 24 ng/mL (range: 4.8 to 64.7 ng/mL). Throughout the study, the median vitamin D levels increased to 48 ng/mL (range: 22.0 to 76.7 ng/mL). Before diagnosis, 16.7% received vitamin D substitution, and 97.8% received vitamin D substitution throughout the year with a median weekly dose of 20,000 IU. It took at least three quarterly assessments for 95% of patients to reach the normal range. A multiple GEE analysis identified associations between 25(OH)D levels and supplementation, season, age, VLDL, magnesium levels, and endocrine therapy. (4) Conclusions: Physicians should monitor 25(OH)D levels before, during, and after oncological therapy to prevent vitamin D deficiency and to adjust substitution individually. While variables such as seasons, age, VLDL, magnesium, diet, and oncological interventions affect 25(OH)D levels, supplementation has the greatest impact.

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“…A total of 19 patients dropped out of the study. Data on tumor biology and tumor entity were previously published [ 10 ]. The median patients’ age was 55 years (min.…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

Zemlin,

Altmayer,

Lang

et al. 2024

Nutrients

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“…However, in this study, physical activity was assessed using questionnaires ( 10 ). To better understand the consequences of physical activity during anticancer therapy on side effects, body composition and physiological parameters, we performed the prospective BEGYN-1 study ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Improved awareness of physical activities is associated with a gain of fitness and a stable body weight in breast cancer patients during the first year of antineoplastic therapy: the BEGYN-1 study

Zemlin,

Schleicher,

Altmayer

et al. 2023

Front. Oncol.

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BackgroundBreast cancer is the most frequent cancer in women. Reduced physical activity and overweight are associated with poor prognosis. Breast cancer patients have a high risk to gain weight, lose muscle mass and reduce physical activity during therapy. Concepts are urgently needed to motivate patients to engage in physical activity.Methods110 non-metastatic breast cancer patients were included in the prospective observational BEGYN-1 study. Physiological parameters and body composition were measured before the start of therapy and then quarterly for one year. Patients used a fitness tracker and documented their physical activity in a diary throughout the study.ResultsAlthough the patients were not offered any guided exercise, and despite the restrictions during the COVID-19 pandemic, they increased their physical activity (metabolic equivalent of task (MET) -minutes): p<0.001), physical fitness (decreasing resting heart rate: p=0.001) and did not gain weight (median - 0.4kg) over the course of the study.ConclusionImproved awareness of physical activity is associated with an increase in physical activity, fitness, and a stable weight during the first year of therapy in breast cancer patients. Counselling at diagnosis should motivate patients to engage in physical activity, wear a fitness tracker and document activities.

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Integrating Therapies: A Rational, Personalised Approach to Metastatic Disease

Kechagioglou,

Fuller-Shavel

2023

Integrative Oncology in Breast Cancer Care

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Prevalence and Relevance of Vitamin D Deficiency in Newly Diagnosed Breast Cancer Patients: A Pilot Study

Cited by 8 publications

References 48 publications

Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

Course of Vitamin D Levels in Newly Diagnosed Non-Metastatic Breast Cancer Patients over One Year with Quarterly Controls and Substitution

Improved awareness of physical activities is associated with a gain of fitness and a stable body weight in breast cancer patients during the first year of antineoplastic therapy: the BEGYN-1 study

Integrating Therapies: A Rational, Personalised Approach to Metastatic Disease

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