Longitudinal assessment of Integra in primary burn management: A randomized pediatric clinical trial*

Branski, Ludwik K.; Herndon, David N.; Pereira, Clifford T.; Mlcak, Ronald P.; Celis, Mario M.; Lee, Jong O.; Sanford, Arthur P.; Norbury, William B.; Zhang, Xiao Jun; Jeschke, Marc G.

doi:10.1097/01.ccm.0000285991.36698.e2

Cited by 151 publications

(84 citation statements)

References 26 publications

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“…14 Our subjective results are comparable to the results of other clinical studies on the use of dermal substitutes. 5,9,14,24,25 Before discussing the limitations of this followup, we will first consider the limitations of the original study. At that time, no randomization procedure was used for choosing the treatment of the wound pair.…”

Section: Discussionmentioning

confidence: 99%

Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-Up

Bloemen

Leeuwen

Vucht

et al. 2010

Plastic and Reconstructive Surgery

108

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Section: Discussionmentioning

confidence: 99%

Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-Up

Bloemen

Leeuwen

Vucht

et al. 2010

Plastic and Reconstructive Surgery

108

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“…tete Wundgrund entweder mit d ü nner Spalthaut oder CEA gedeckt werden kann. Neuere Studien zeigen, dass das Intervall, welches zur Einheilung der dermalen Komponente ben ö tigt wird, durch Einsatz der Vakuumversiegelung (VAC ® ) deutlich beschleunigt und in Bezug auf die Einheilungsrate entscheidend verbessert werden kann [49] . Suprathel ® , ebenfalls ein zu den synthetischen Produkten z ä hlender Hautersatz, wird in den letzten Jahren zunehmend bei zweitgradigen Verbrennungen und bei der Behandlung von Spalthaut -Spenderstellen eingesetzt (klinisches Beispiel • ▶ Abb.…”

Section: Kultivierte Zellen Auf Alloplastischen Oder Gemischt Synthetunclassified

Tissue Engineering von Haut - von der Spalthaut zum gezüchteten Hauttransplantat?

Beier¹,

Boos²,

Kamolz³

et al. 2010

Handchir Mikrochir plast Chir

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Today split or full skin grafts are still the gold standard in the treatment of substance defects of the skin. Such results can be seen, for example, in the therapy for burn patients. However, in patients with more than 50% burned skin area, donor sites are limited. Likewise in chronic wound patients inferior take rates of skin grafts as compared to burn wounds are observed. This may be attributed, for example, to accompanying or underlying chronic diseases or a higher rate of local infections. These phenomena also lead to a lack of availability of transplantable skin grafts. Hence the need for cost effective and user friendly synthetic or engineered skin grafts, which can serve for acute and chronic wounds and which can be also used in critically ill patients, is at hand. During the last 30 years a huge number of biological and synthetic skin graft materials and products based on the patient's own cells were launched on the market. Researchers and clinicians are constantly working on further improvements. One possibility is the engineering of skin grafts in vitro, which have to be integrated into the wound bed after transplantation. Another approach is the fabrication of biocompatible and bioresorbable matrices, which can attract host cells and stimulate a wound-healing process without scars. However, the skin graft materials available today cannot yet replace split or full skin grafts completely because of their inherent limitations such as insufficient take rates and/or the lack of mechanical stability and differentiated structures of the grafted artificial skin. Thus researchers in the field of skin tissue engineering are still working on the final goal of developing a skin graft which has all the features of healthy human skin and is capable of replacing human skin completely. This article gives on overview of the currently available solutions and products in the field of skin tissue engineering.

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“…Biobrane have been developed [5]. These skin substitutes have greatly improved the long-term function and appearance, with lower wound contraction and less pigmentation [6,7].…”

Section: Introductionmentioning

confidence: 99%

Collagen/chitosan based two-compartment and bi-functional dermal scaffolds for skin regeneration

Wang

She

et al. 2015

Materials Science and Engineering: C

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Longitudinal assessment of Integra in primary burn management: A randomized pediatric clinical trial*

Abstract: Integra can be used for immediate wound coverage in children with severe burns without the associated risks of cadaver skin.

Cited by 151 publications

References 26 publications

Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-Up

Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-Up

Tissue Engineering von Haut - von der Spalthaut zum gezüchteten Hauttransplantat?

Collagen/chitosan based two-compartment and bi-functional dermal scaffolds for skin regeneration

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