Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-Up

Bloemen, M.C.T.; Leeuwen, Michiel C. E. van; Vucht, Niels E. van; Zuijlen, Paul P. M. van; Middelkoop, Esther

doi:10.1097/prs.0b013e3181d62b08

Cited by 108 publications

(77 citation statements)

References 25 publications

(19 reference statements)

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“…DRT provides an alternative option for wound closure, in the acute setting, in critically ill patients with extensive injuries where otherwise major reconstructive flaps would be considered risky and morbid. Furthermore, DRTs are able to provide long-term functional and cosmetic outcomes with improved skin texture and pliability, results that are comparable to that of autologous skin graft [4][5][6].…”

Section: Introductionmentioning

confidence: 76%

The use of dermal regeneration template (Pelnac®) in acute full-thickness wound closure: A case series

Widjaja

Maitz

2015

Eur J Plast Surg

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Background Dermal regeneration template (DRT) has been well implicated in the reconstruction of fullthickness burn injury. This case series specifically presents our experience and our clinical application of Pelnac® to achieve wound closure with complex acute full-thickness defect. Methods A retrospective review of patients treated with Pelnac for complex wound defects from 2008 to 2014 at Concord Burns Unit was carried out. Variables such as wound aetiology, wound size and complications were considered. Results Five patients (four females and one male with a mean age 54±20) all had full-thickness defects (mean defect size 4.3±2.0 % TBSA), some with exposed tendon and bone. The wounds were treated with Pelnac®; the silicone layer was removed at postoperative day 14 and a split-thickness skin graft (0.2 to 0.3 mm) was applied. Clinically, the reconstructed areas demonstrated good granulation tissue at 14 days with good take of the skin graft. There were no major acute graft loss, rejection or associated infection. However, there were small areas of graft loss which did not require regrafting.Conclusions DRT provides a safe and efficacious alternative when dealing with acute contaminated full-thickness wounds. Pelnac® seems versatile in obtaining wound coverage in difficult complex wounds, especially in critically ill patients where free or pedicle flap reconstruction would be problematic. Level of Evidence: Level V, therapeutic study.

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Section: Introductionmentioning

confidence: 76%

The use of dermal regeneration template (Pelnac®) in acute full-thickness wound closure: A case series

Widjaja

Maitz

2015

Eur J Plast Surg

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“…However, there was a perceived improvement for MatriDerm 1 -grafted wounds compared with control wounds in subjective scar assessment conducted by patients and clinicians [38]. MatriDerm 1 has proved particularly useful in the treatment of hand burns, which are reported in 60-90% of burn cases [40,41]. A long-term follow-up of upper-extremity wounds treated with this scaffold in combination with a sheet autograft reveals good skin pliability, scar height, and ultimately, hand function [41].…”

Section: Discussionmentioning

confidence: 99%

Glyaderm® dermal substitute: Clinical application and long-term results in 55 patients

Pirayesh

Hoeksema

Richters³

et al. 2015

Burns

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“…Its function is to enhance skin elasticity and improve the resulting scar quality in wounds, especially in the case of burns (44)(45)(46)(47)(48).…”

Section: Matriderm ®mentioning

confidence: 99%

The Use of Dermal Substitutes in Burn Surgery: Acute Phase

Arno¹,

Jeschke²

2013

Dermal Replacements in General, Burn, and Plastic Surgery

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Dermal substitutes are increasingly becoming an essential part of the burn care strategy. During the acute phase of burn treatment, dermal substitutes improve functional and cosmetic results long-term and thus increase quality of life. In the chronic wound setting, dermal substitutes are used to reconstruct and improve burn scars and other defects. Despite some successes in the use of dermal substitutes there are more needs and requirements to further improve outcomes and hence further research is required not only to strengthen scientific evidence regarding their effects but also to develop new technology and products. Dermal substitutes also emerge as pivotal research strategies to develop adequate scaffolds for stem cells, tissue engineering and regenerative medicine applications to obtain long-lasting and scarless artificial skin. This review discusses status-quo of dermal substitutes and novel strategies in the use of dermal substitutes with a focus on burn care.

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Dermal Substitution in Acute Burns and Reconstructive Surgery: A 12-Year Follow-Up

Abstract: In this first long-term and objective follow-up of dermal substitution, the authors found improved scar parameters in both acute and reconstructive wounds treated with the substitute, indicating a long-lasting effect on scar quality.

Cited by 108 publications

References 25 publications

The use of dermal regeneration template (Pelnac®) in acute full-thickness wound closure: A case series

The use of dermal regeneration template (Pelnac®) in acute full-thickness wound closure: A case series

Glyaderm® dermal substitute: Clinical application and long-term results in 55 patients

The Use of Dermal Substitutes in Burn Surgery: Acute Phase

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