Longitudinal assessment of immunological and oral clinical conditions in patients undergoing anticancer treatment for leukemia

Thomaz, Érika Bárbara Abreu Fonseca; Mouchrek, José Carlos Elias; Silva, Adriana Quinzeiro; Guerra, Rosane Nassar Meireles; Libério, Silvana Amado; Cruz, Maria Carmen Fôntoura Nogueira da; Pereira, António Luis

doi:10.1016/j.ijporl.2013.03.037

Cited by 18 publications

(17 citation statements)

References 28 publications

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“…According to those authors, a statistically significant low salivary S-IgA level was maintained after chemotherapy. 18 A statistically significant lower level of saliva IgA in patients with leukemia (2.9-1.9 μg/mL) as compared to controls (5.4 μg/mL) was reported by Thomaz et al 19 Månsson-Rahemtulla et al also reported that the value of saliva IgA in patients with ALL undergoing chemotherapy was significantly reduced. The authors revealed that at the time of diagnosis, salivary IgA in patients with ALL was 0.183 ±0.193 mg/mL, and that it was higher than in the control group.…”

Section: Discussionmentioning

confidence: 75%

“…Similar correlations have also been observed by other authors. [16][17][18][19][20] Mucositis is most frequently induced by a reduced number of white blood cells, the use of cytotoxic antibiotics and by alkylating factors. 16,17 A significant decrease in salivary S-IgA following chemotherapy in children with leukemia was reported by Karolewska et al, although the authors did not report differences in the S-IgA concentration in comparison with the control group prior to anti-tumor treatment.…”

Section: Discussionmentioning

confidence: 99%

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Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Pels¹

2017

Adv Clin Exp Med

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Pels¹

2017

Adv Clin Exp Med

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“…B) Due to rampant caries and demineralization, because of the rapid formation of cavities or dental erosion caused by a disruption of the salivary flow and consistency as well as by the quality in food, which tends to be doughy or liquid in the presence of xerostomia or mucositis 31,32 .…”

Section: After Treatmentmentioning

confidence: 99%

Oral Alterations in children with cancer. Literature review.

Cortés-Ramírez¹,

Ayala²,

Torre³

et al. 2014

Joralres

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For dentists, there is little information on malignant tumors and complications both because their natural evolution is secondary to treatment, despite cancer in children represents 3% of all cancer cases. The goal is to make a brief review of the most common neoplasm in children, to identify them and find out the oral alterations with highest incidence both as secondary to the pathology and as a side effect of treatment. This review analyses various types of malignant neoplasms which may occur in this stage of life. They are divided into haematological: leukemias, lymphomas and solid tumors. The most common leukemia is acute lymphoblastic (ALL) followed by acute myeloid and granulocytic. Lymphomas develop from the lymphatic system and are divided into Hodgkin's and non-Hodgkin's. Cancer has become a chronic disease favoring a new group of patients who achieve survival but suffer side effects due to therapies, drugs, doses and the child's characteristics. Oral complications appear in 40% of cases and the most frequent are mucositis, opportunistic infection, xerostomia, bleeding, periodontal disease and disorders in the development of teeth and jaw. Although cancer is located outside of the maxillofacial area, chemotherapy is aggressive for a developing organism. The side effects of radiation therapy affect the general and specific area to radiate as well as the surrounding organs and tissues. Recently, advances in diagnosis and treatment have increased survival from 20% to 80%, with long-term treatment.

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“…These manifestations may delay treatment, aggravate the pathological picture and lead the patient to death. Such manifestations are more observed in acute leukemia, and in patients undergoing chemotherapy treatment [4].…”

Section: Introductionmentioning

confidence: 99%

Oral Manifestations and Salivary pH Changes in Children undergoing Antineoplastic Therapy

Hanna¹,

Botti²,

Araújo

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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Objective: To identify the oral manifestations and salivary pH before and after chemotherapy in pediatric patients. Material and Methods: The sample consisted of 46 children. It was included children from 2 to 12 years, diagnosed with Acute Lymphoblastic Leukemia (ALL) and they would be subjected to chemotherapy. The first evaluation was performed before chemotherapy and consisted of anamnesis, oral clinical examination and saliva collection to measure the pH. The second evaluation was performed among 10 to 15 days after the start of chemotherapy treatment and consisted of new saliva collection and clinical examination. Results: The results showed that the gender most affected by childhood cancer was male. The predominant age group were children aged 8-12 years. The most frequent oral manifestations were mucositis (35%), xerostomia (26%), toothache and dysphagia (22%). There was also a significant reduction in salivary pH after chemotherapy, p <0.0001, indicating that the average pre and post chemotherapy are different (Δ = 10.6) with statistical significance at the 5% level. Conclusion: Patients with ALL can present any lesion in the oral cavity during or after the start of chemotherapy and undergo changes in the amount of salivary pH. The dentist needs and know the oral manifestations and intervene in the oral health of patients with ALL, contributing and assisting in their treatment.

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Longitudinal assessment of immunological and oral clinical conditions in patients undergoing anticancer treatment for leukemia

Cited by 18 publications

References 28 publications

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Oral mucositis and saliva IgA, IgG and IgM concentration during anti-tumor treatment in children suffering from acute lymphoblastic leukemia

Oral Alterations in children with cancer. Literature review.

Oral Manifestations and Salivary pH Changes in Children undergoing Antineoplastic Therapy

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