Longitudinal assessment of gait abnormalities following penetrating ballistic-like brain injury in rats

Mountney, Andrea; Leung, Lai Yee; Pedersen, Rebecca; Shear, Deborah A.; Tortella, Frank C.

doi:10.1016/j.jneumeth.2012.08.025

Cited by 27 publications

(28 citation statements)

References 34 publications

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“…As reported in our data, previous works have brought evidence of a locomotor impairments following Pb exposure. Indeed, in adult rat, chronic [12] and acute [68] exposition to Pb, reduced considerably the walking speed which was associated with a reduction in stance duration [37]. A large base-of-support that can compensate for an instable gait [38] and a decreased stride length finding was observed following contusion and dorsal transection injuries especially in hindlimbs [35,37].…”

Section: Discussionmentioning

confidence: 99%

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Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

et al. 2017

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Lead poisoning is one of the most significant health problem of environmental origin. It is known to cause different damages in the central and peripheral nervous system which could be represented by several neurophysiological and behavioral symptoms. In this study we firstly investigated the effect of lead prenatal exposure in rats to (3g/L), from neonatal to young age, on the motor/sensory performances, excitability of the spinal cord and gaits during development. Then we evaluated neuroprotective effects of curcumin I (Cur I) against lead neurotoxicity, by means of grasping and cliff avoidance tests to reveal the impairment of the sensorimotor functions in neonatal rats exposed prenatally to lead. In addition, extracellular recordings of motor output in spinal cord revealed an hyper-excitability of spinal networks in lead treated rats. The frequency of induced fictive locomotion was also increased in treated rats. At the young age, rats exhibited an impaired locomotor gait. All those abnormalities were attenuated by Cur I treatment at a dose of 16g/kg. Based on our finding, Cur I has shown features of a potent chemical compound able to restore the neuronal and the relative locomotor behaviors disturbances induced by lead intoxication. Therefore, this chemical can be recommended as a new therapeutic trial against lead induced neurotoxicity.

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Section: Discussionmentioning

confidence: 99%

“…The required training protocol has been described elsewhere [35, 36, 37, 38]. Briefly, the CatWalk is a highly sensitive device consisting of a 1.3 m long glass plate illuminated on the side by dim fluorescent lighting.…”

Section: Methodsmentioning

confidence: 99%

Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

et al. 2017

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“…Studies using analysis of gait in TBI patients have revealed deficits compared to healthy controls. The CatWalk-XT gait-analysis system has been used to measure deficits in a variety of rodent brain-injury models [65][66][67][68]. Gait analysis one month after injury revealed significant (p<0.05) deficits in the TBI group, in locomotor speed and in the swing speed of all four limbs.…”

Section: Locomotor Outcomes 1 Month After Injurymentioning

confidence: 99%

Xenon Improves Neurologic Outcome and Reduces Secondary Injury Following Trauma in an In Vivo Model of Traumatic Brain Injury*

Campos-Pires

Armstrong

Sebastiani

et al. 2015

Critical Care Medicine

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Objectives-To determine the neuroprotective efficacy of the inert gas xenon following traumatic brain injury, and to determine whether application of xenon has a clinically relevant therapeutic time window.Design-Controlled animal study. Setting-University research laboratory. Subjects-Male C57BL/6N mice (n=196)Interventions-75% xenon, 50% xenon or 30% xenon, with 25% oxygen (balance nitrogen) treatment following mechanical brain lesion by controlled cortical impact.Measurements & Main Results-Outcome following trauma was measured using: 1) functional neurological outcome score, 2) histological measurement of contusion volume, 3) analysis of locomotor function and gait. Our study shows that xenon-treatment improves outcome following traumatic brain injury. Neurological outcome scores were significantly (p<0.05) better

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“…We assessed outcome following CCI using a Noldus Catwalk automated gait analysis system, which permits simultaneous, observer-independent analysis of both temporal and spatial aspects of interlimb coordination. This system has been used in previous studies to assess the degree of functional impairment after brain injury in rodents (Mountney et al, 2013; Neumann et al, 2009; Wang et al, 2011). One of these previous investigations used the Catwalk system to assess injury in a mouse model with similar CCI parameters to those used in our study and found deficits related to the injury that overlapped with most of the parameters that were improved by paclitaxel treatment in our study, including intensity, maximum area, print area, print width, and swing (Neumann et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Catwalk gait analysis has been used previously to evaluate impairment following CCI in rodents (Mountney et al, 2013; Neumann et al, 2009; Wang et al, 2011). CCI injury is unilateral and with our mild impact, we required a sensitive test of motor/neurological function.…”

Section: Methodsmentioning

confidence: 99%

Paclitaxel improves outcome from traumatic brain injury

et al. 2015

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Pharmacologic interventions for traumatic brain injury (TBI) hold promise to improve outcome. The purpose of this study was to determine if the microtubule stabilizing therapeutic paclitaxel used for more than 20 years in chemotherapy would improve outcome after TBI. We assessed neurological outcome in mice that received direct application of paclitaxel to brain injury from controlled cortical impact (CCI). Magnetic resonance imaging was used to assess injury-related morphological changes. Catwalk Gait analysis showed significant improvement in the paclitaxel group on a variety of parameters compared to the saline group. MRI analysis revealed that paclitaxel treatment resulted in significantly reduced edema volume at site-of-injury (11.92 ± 3.0 and 8.86 ± 2.2 mm3 for saline vs. paclitaxel respectively, as determined by T2-weighted analysis; p ≤ 0.05), and significantly increased myelin tissue preservation (9.45 ± 0.4 vs. 8.95 ± 0.3, p ≤ 0.05). Our findings indicate that paclitaxel treatment resulted in improvement of neurological outcome and MR imaging biomarkers of injury. These results could have a significant impact on therapeutic developments to treat traumatic brain injury.

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Longitudinal assessment of gait abnormalities following penetrating ballistic-like brain injury in rats

Cited by 27 publications

References 34 publications

Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

Xenon Improves Neurologic Outcome and Reduces Secondary Injury Following Trauma in an In Vivo Model of Traumatic Brain Injury*

Paclitaxel improves outcome from traumatic brain injury

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