Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

Benammi, Hind; Erazi, Hasna; Hiba, Omar El; Vinay, Laurent; Bras, Hélène; Viemari, Jean‐Charles; Gamrani, Halima

doi:10.1371/journal.pone.0172715

Cited by 15 publications

(10 citation statements)

References 87 publications

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“…After exposure of adolescent until adulthood Wistar rats to 50 mg/kg Pb acetate, tissue Pb levels were measured in cerebellar tissue, indicating Pb accumulation in this area. The Pb accumulation found with this exposure is similar to that described for exposed children by the CDC's National Surveillance [33], and several studies have used animals models to mimic the infant exposure to Pb, highlighting the reflex over the developing CNS motor function [34][35][36].…”

Section: Discussionsupporting

confidence: 66%

Long-Term Lead Exposure Since Adolescence Causes Proteomic and Morphological Alterations in the Cerebellum Associated with Motor Deficits in Adult Rats

Leão

Bittencourt

Oliveira

et al. 2020

IJMS

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Lead (Pb) is an environmental contaminant that presents a high risk for human health. We aimed to investigate the possible alterations triggered by the exposure to Pb acetate for a long period in motor performance and the possible relationship with biochemical, proteomic and morphological alterations in the cerebellum of rats. Male Wistar rats were exposed for 55 days, at 50 mg/Kg of Pb acetate, and the control animals received distilled water. Open field (OF) and rotarod tests; biochemistry parameters (MDA and nitrite); staining/immunostaining of Purkinje cells (PC), mature neurons (MN), myelin sheath (MS) and synaptic vesicles (SYN) and proteomic profile were analyzed. Pb deposition on the cerebellum area and this study drove to exploratory and locomotion deficits and a decrease in the number of PC, MN, SYN and MS staining/immunostaining. The levels of MDA and nitrite remained unchanged. The proteomic profile showed alterations in proteins responsible for neurotransmitters release, as well as receptor function and second messengers signaling, and also proteins involved in the process of apoptosis. Thus, we conclude that the long-term exposure to low Pb dose promoted locomotion and histological tracings, associated with alterations in the process of cell signaling, as well as death by apoptosis.

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Section: Discussionsupporting

confidence: 66%

Long-Term Lead Exposure Since Adolescence Causes Proteomic and Morphological Alterations in the Cerebellum Associated with Motor Deficits in Adult Rats

Leão

Bittencourt

Oliveira

et al. 2020

IJMS

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“…Pb neurotoxicity produced alterations in locomotor neuronal network development and curcumin treatment reversed these anomalies, allowing normal locomotor behavior. These findings indicate that curcumin has the capability to prevent central nervous system dysfunction induced by lead during the earlier stages of development [ 61 ].…”

Section: Role Of Curcumin In Pregnancymentioning

confidence: 99%

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

et al. 2020

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Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed in various chronic diseases in humans, limited and fragmentary information is currently available about curcumin’s effects on pregnancy and pregnancy-related complications. It is known that immune-metabolic alterations occurring during pregnancy have consequences on both maternal and fetal tissues, leading to short- and long-term complications. The reported anti-inflammatory, antioxidant, antitoxicant, neuroprotective, immunomodulatory, antiapoptotic, antiangiogenic, anti-hypertensive, and antidiabetic properties of curcumin appear to be encouraging, not only for the management of pregnancy-related disorders, including gestational diabetes mellitus (GDM), preeclampsia (PE), depression, preterm birth, and fetal growth disorders but also to contrast damage induced by natural and chemical toxic agents. The current review summarizes the latest data, mostly obtained from animal models and in vitro studies, on the impact of curcumin on the molecular mechanisms involved in pregnancy pathophysiology, with the aim to shed light on the possible beneficial and/or adverse effects of curcumin on pregnancy outcomes.

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“…44 Furthermore, endothelin-1-induced ischemic damage to the anterior motor cortex consistently induced paw dragging behavior along the cylinder wall in the cylinder test instead of pushing off of the wall when moving from a rearing to a four-legged stance. 46,47 In addition, forepaw fine motor grasping and reaching responses were impaired after manganese 41 or prenatal lead 42 exposure as well as fore and hind limb gait deficits. 42 In a mouse model of Parkinson’s disease, forepaw sensorimotor function was impaired in the adhesive removal test.…”

Section: Discussionmentioning

confidence: 99%

“…46,47 In addition, forepaw fine motor grasping and reaching responses were impaired after manganese 41 or prenatal lead 42 exposure as well as fore and hind limb gait deficits. 42 In a mouse model of Parkinson’s disease, forepaw sensorimotor function was impaired in the adhesive removal test. 43 In addition, behaviors requiring forepaw sensorimotor function were consistently impaired on the adjusting steps test, challenging beam test, pole test, spontaneous activity test, and limb-use asymmetry test, whereas overall gait analysis was more variable.…”

Section: Discussionmentioning

confidence: 99%

Front and hind paw differential analgesic effects of amitriptyline, gabapentin, ibuprofen, and URB937 on mechanical and cold sensitivity in cisplatin-induced neuropathy

et al. 2019

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Cisplatin is a widely used platinum-derived antineoplastic agent that frequently results in peripheral neuropathy. Therapeutic strategies for neuropathic pain are limited and characterized by variable efficacy and severe adverse effects. Clinical translation of novel analgesics has proven difficult with many agents demonstrating preclinical efficacy failing in clinical trials. Preclinical studies frequently assess pain behaviors in the hind paws; however, the front paws have a greater degree of the fine sensorimotor functions characteristically damaged by chemotherapy-induced neuropathy. This is the first study to assess pain responses in the front paws. Here, we test the hypothesis that mouse front paws exhibit pain-related alterations in mechanical and thermal (cold) sensitivity in a murine model of cisplatin-induced neuropathy and that pharmacological treatment with amitriptyline, gabapentin, ibuprofen, and URB937 normalize pain behaviors in the front and hind paws. Cold (acetone withdrawal latencies) and mechanical (von Frey withdrawal thresholds) sensitivity were significantly increased and decreased respectively in both the front and the hind paws following initiation of weekly systemic (intraperitoneal) cisplatin injections (5 mg/kg). For the hind paws, systemic administration of amitriptyline (30 mg/kg), gabapentin (100 mg/kg), ibuprofen (0–10 mg/kg), or URB937 (0–10 mg/kg) resulted in a decrease in acetone withdrawal latencies and increase in von Frey withdrawal thresholds with return to normal values at the highest doses tested. For the front paws, return to baseline values for the highest doses was found for cold allodynia but not mechanical allodynia, where the highest doses failed to return to baseline values. These results indicate that mouse front paws exhibit pain-related changes in cisplatin-induced neuropathy and that drug effects can vary based on testing stimulus and location. This suggests that front paw responses across multiple modalities provide reliable and accurate information about pain-related drug effects. Future studies should be aimed at elucidating the mechanisms underlying these differential effects.

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Disturbed sensorimotor and electrophysiological patterns in lead intoxicated rats during development are restored by curcumin I

Cited by 15 publications

References 87 publications

Long-Term Lead Exposure Since Adolescence Causes Proteomic and Morphological Alterations in the Cerebellum Associated with Motor Deficits in Adult Rats

Long-Term Lead Exposure Since Adolescence Causes Proteomic and Morphological Alterations in the Cerebellum Associated with Motor Deficits in Adult Rats

Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Front and hind paw differential analgesic effects of amitriptyline, gabapentin, ibuprofen, and URB937 on mechanical and cold sensitivity in cisplatin-induced neuropathy

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