Longitudinal Analysis of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Carriage in Healthy Adolescents

Chen, Chih‐Jung; Wang, Shao-Chung; Chang, Hsin-Yu; Huang, Yhu-Chering

doi:10.1128/jcm.00572-13

Cited by 20 publications

(22 citation statements)

References 35 publications

(39 reference statements)

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“…Other studies from Europe showed similar colonization rates (Sakwinska et al, 2009;Lozano et al, 2011;Mehraj et al, 2014;Holtfreter et al, 2016). Similar or slightly elevated carriage rates were also reported in studies from Australia and several Asian countries (Munckhof et al, 2008;Chatterjee et al, 2009;Ma et al, 2011;Chen et al, 2013). Significantly higher rates were recorded in Southern European countries and the United States (up to 35%, Tavares et al, 2013;Champion et al, 2014).…”

Section: Methicillin-resistant Staphylococcus Aureus In General and Hsupporting

confidence: 69%

Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Workers in the Food Industry

Strommenger

Layer

Werner

2018

Staphylococcus Aureus

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Section: Methicillin-resistant Staphylococcus Aureus In General and Hsupporting

confidence: 69%

Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Workers in the Food Industry

Strommenger

Layer

Werner

2018

Staphylococcus Aureus

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“…A quarter of the mothers were defined as transient carriers, of which most carried S. aureus in only one or two carriage events. In line with previous studies, we observed strain persistence in our healthy adult population, (12, 17). MRSA was not isolated from any mother at any point throughout the year.…”

Section: Discussionsupporting

confidence: 93%

Patterns and predictors ofStaphylococcus aureuscarriage during the first year of life; a longitudinal study

Reiss-Mandel

Rubin

Maayan-Mezger

et al. 2019

Preprint

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Objectives’To determine the patterns of S. aureus carriage in the first year of life, its determinants and dynamics of transmission between mothers and infants.MethodsProspective longitudinal cohort study of S. aureus carriage among mothers and their infants. Monthly screenings from pregnancy/birth through the first year of the infant’s life. Medical and lifestyle data was collected. Infant S. aureus carriage was detected by rectal and nasal swabs and maternal carriage by nasal swabs. Multivariate analysis and an NLMixed model were used to determine predictors of carriage and S. aureus persistence.Results130 S. aureus carrier women and their 132 infants were included in the study. 93% of the infants acquired S. aureus sometime during the first year of life, 64% of them acquired the maternal strain, mostly (66%) during the first month of life. 70 women (52.50%) and 17 infants (14%) carried S. aureus persistently. Early acquisition of S. aureus carriage was associated with longer duration of initial carriage and was the most significant predictor of S. aureus persistence, while day-care center attendance was negatively associated with persistent carriage.ConclusionsEarly acquisition of S. aureus, mostly from the mother, is an important determinant of carriage persistence in infancy.

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“…12 The t026 clone is also reported to be carried in healthy adolescents in a longitudinal surveillance in Taiwan and is considered to be a globally spread clone. 9 The t1081 clone has been predominantly found in long-term care facilities in hospitals in Hong Kong since 2005 as a member of ST45/ SCCmec IV or V. 11 t074 has been reported to be highly correlated to t037 and t421, which can be clustered together by PFGE typing and share an approximately 75% similarity in their spa sequence. 27 In summary, in this study, SCCmec type III, IV, and V were the major SCCmec subtypes in our MRSA isolates.…”

Section: Discussionmentioning

confidence: 98%

Molecular Characterization of Community- and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus Isolates in Southern Taiwan

Lee

Yang

et al. 2015

Microbial Drug Resistance

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A growing tendency for community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) to be involved in nosocomial infections was reported. The predominance of SCCmec type IV or V CA-MRSA in soft tissue infection has also been indicated in Northern Taiwan. To establish basic information about the molecular characteristics of MRSA in our region, a total of 102 MRSA isolates were collected and characterized by an array of typing methods. Healthcare-associated MRSA (HA-MRSA) were found to be more resistant to levofloxacin (p=0.016) and moxifloxacin (p=0.015) than CA-MRSA. However, no difference was found in each and overall SCCmec type distribution between the two MRSA groups. Type I (8.7% vs. 2.6%) was more frequently found in CA-MRSA, whereas type V was more often observed in HA-MRSA (24.4% vs. 8.7%). No difference was found in the dichotomous group of PVL, SCCmec type IV, V, and IV/V between the two MRSA groups. Twenty-seven distinct spa types were identified; t437 and t1081 were the predominant types in our isolates. Moreover, 12 novel spa types with extremely low global frequency were detected in our isolates. SCCmec type III and IV were the major subtypes in the MRSA we collected. The t1081 clones all belonged to HA-MRSA and mostly to SCCmec type V (71.4%). CA-MRSA t437 clones were mostly SCCmec type IV strains (71.4%), but HA-MRSA t437 clones were predominantly SCCmec type IV (42.1%) and III (36.8%). Our findings support a difference in the molecular characteristics of CA-MRSA and HA-MRSA that may reflect various clonal origins in our isolates.

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Longitudinal Analysis of Methicillin-Resistant and Methicillin-Susceptible Staphylococcus aureus Carriage in Healthy Adolescents

Cited by 20 publications

References 35 publications

Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Workers in the Food Industry

Staphylococcus aureus and Methicillin-Resistant Staphylococcus aureus in Workers in the Food Industry

Patterns and predictors ofStaphylococcus aureuscarriage during the first year of life; a longitudinal study

Molecular Characterization of Community- and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus Isolates in Southern Taiwan

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