Longitudinal Analysis of Diabetic Choroidopathy in Proliferative Diabetic Retinopathy Treated With Panretinal Photocoagulation Using Widefield Swept-Source Optical Coherence Tomography

Russell, Jonathan F.; Zhou, Hao; Shi, Yingying; Shen, Mengxi; Gregori, Giovanni; Feuer, William J.; Wang, Ke; Rosenfeld, Philip J.

doi:10.1097/iae.0000000000003375

Cited by 11 publications

(4 citation statements)

References 34 publications

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“…This finding also indicates that dynamic changes in CC may have happened during the development of CSC. Like in other vascular beds, both perfusion pressure and resistance determine blood flow in the choroid (Russell et al, 2022). Blood from the ophthalmic artery flows through the posterior ciliary arteries, into the Sattler's and Haller's layers, and then reaches the CC (Nickla and Wallman, 2010;Russell et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Like in other vascular beds, both perfusion pressure and resistance determine blood flow in the choroid (Russell et al, 2022). Blood from the ophthalmic artery flows through the posterior ciliary arteries, into the Sattler's and Haller's layers, and then reaches the CC (Nickla and Wallman, 2010;Russell et al, 2022). From the CC, blood is drained out through the lobular venules.…”

Section: Discussionmentioning

confidence: 99%

“…From the CC, blood is drained out through the lobular venules. Those lobular venules will converge into the large choroidal veins and then the vortex veins, so that blood leaves the ocular circulation through the superior and inferior ophthalmic veins (Nickla and Wallman, 2010;Spaide 2020;Russell et al, 2022). Following a pressure gradient, the blood flows through the CC in an end-arterial manner due to the drainage through the venules (Lee et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

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Wide-field OCT-angiography assessment of choroidal thickness and choriocapillaris in eyes with central serous chorioretinopathy

Meng

Xu²,

Li³

et al. 2022

Front. Physiol.

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Purpose: To assess wide-field changes in choroidal thickness and choriocapillaris in eyes with central serous chorioretinopathy (CSC) compared with the fellow eyes and eyes from healthy individuals using wide-field swept-source (SS) OCT-Angiography (OCTA).Methods: A cross-sectional study in which 68 eyes from 34 individual patients affected by unilateral CSC and 32 eyes of 32 age- and sex-matched healthy subjects were evaluated. All subjects underwent wide-field SS-OCTA examination to quantify choroidal thickness and vascular density of the choriocapillaris. To assess the wide-field changes, we developed five 4-by-4 mm square regions located in the posterior pole and in the four quadrants of the peripheral retina (superotemporal, inferotemporal, superonasal, and inferonasal subfields, respectively).Results: The choroidal thickness of eyes with CSC was greater than that of the fellow eyes in the central and inferonasal subfields (p < 0.001 for the central subfield and p = 0.006 for the inferonasal subfield, respectively). Compared with the choroidal thickness of healthy eyes, that of patients with CSC were significantly greater in all the subfields (p < 0.05 for the fellow eyes and p < 0.05 for eyes with CSC, respectively). Compared with that of healthy eyes, the vascular density of choriocapillaris in eyes of patients with CSC were significantly greater in the central and superotemporal subfields (p < 0.05 for the fellow eyes and p < 0.05 for eyes with CSC, respectively). In the central region, the vascular density of choriocapillaris of the fellow eyes was greater than eyes with CSC (p = 0.023).Conclusion: CSC appears to be a bilateral disease with asymmetric manifestations. Local factors of the diseased eyes may play an important role in the development of CSC, during which dynamic and regional changes in the choriocapillaris may have happened. Wide-field swept-source OCTA provided a useful tool to study the pathogenesis of CSC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Wide-field OCT-angiography assessment of choroidal thickness and choriocapillaris in eyes with central serous chorioretinopathy

Meng

Xu²,

Li³

et al. 2022

Front. Physiol.

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“…Although panretinal photocoagulation produced a choroidal thinning outside the foveal region, the CVI tended to remain lower than in healthy subjects. This finding was interpreted as a decrease in choroidal vascularity in PDR eyes [ 90 ].…”

Section: Clinical and Prognostic Significance Of Diabetic Choroidopathymentioning

confidence: 99%

The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy

Scuderi

Fragiotta

Pippo

et al. 2023

IJMS

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Diabetic choroidopathy was first described on histopathological specimens of diabetic eyes. This alteration was characterized by the accumulation of PAS-positive material within the intracapillary stroma. Inflammation and polymorphonuclear neutrophils (PMNs) activation are crucial elements in choriocapillaris impairment. The evidence of diabetic choroidopathy in vivo was confirmed with multimodal imaging, which provides key quantitative and qualitative features to characterize the choroidal involvement. The choroid can be virtually affected in each vascular layer, from Haller’s layer to the choriocapillaris. However, the damage on the outer retina and photoreceptor cells is essentially driven by a choriocapillaris deficiency, which can be assessed through optical coherence tomography angiography (OCTA). The identification of characteristic features of diabetic choroidopathy can be significant for understanding the potential pathogenic and prognostic implications in diabetic retinopathy.

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Choriocapillaris Flow Deficit as a Biomarker for Diabetic Retinopathy and Diabetic Macular Edema: 3-Year Longitudinal Cohort

Chen¹,

Zhu²,

Cheng³

et al. 2023

American Journal of Ophthalmology

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Longitudinal Analysis of Diabetic Choroidopathy in Proliferative Diabetic Retinopathy Treated With Panretinal Photocoagulation Using Widefield Swept-Source Optical Coherence Tomography

Cited by 11 publications

References 34 publications

Wide-field OCT-angiography assessment of choroidal thickness and choriocapillaris in eyes with central serous chorioretinopathy

Wide-field OCT-angiography assessment of choroidal thickness and choriocapillaris in eyes with central serous chorioretinopathy

The Role of Diabetic Choroidopathy in the Pathogenesis and Progression of Diabetic Retinopathy

Choriocapillaris Flow Deficit as a Biomarker for Diabetic Retinopathy and Diabetic Macular Edema: 3-Year Longitudinal Cohort

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