Choriocapillaris Flow Deficit as a Biomarker for Diabetic Retinopathy and Diabetic Macular Edema: 3-Year Longitudinal Cohort

Chen, Yanping; Zhu, Zhuoting; Cheng, Weiqiang; Bulloch, Gabriella; Chen, Yifan; Liao, Huan; Li, Yuting; Liang, Xiaoling; Huang, Wenyong; He, Mingguang; Wang, Wei

doi:10.1016/j.ajo.2022.11.018

Cited by 9 publications

(3 citation statements)

References 49 publications

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“…However, CC FD could be accurately calculated from CC images by fuzzy C means algorithm and could indirectly reflect the changes of CC vessel density, which might solve above problems 22 . Recently, CC FD has been widely used as a novel biomarker to reflect the development and activity of various eye diseases, such as diabetic retinopathy and age-related macular degeneration 12 , 13 . The decrease of CC FD in our study suggested the dilation of CC, which was also be found in the uninvolved fellow eyes of CSC 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the circadian rhythm disorders might impact the ocular microvasculature and might even induce retinal diseases. In this study, we explored the changes of retinal and choroidal microvessels in regular night shift medical workers by swept-source OCTA (SS-OCTA), and analyzed choriocapillaris flow deficit (CC FD) which has been confirmed as a sensitive and new indicator of occurrence and progress in many ophthalmic diseases 12 , 13 . In addition, as an important hormone in circadian rhythm disorders, the relationship between melatonin and ocular microvasculature was also analyzed in our study.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of retinal and choroidal microvasculature in night shift medical workers by OCT angiography

Liang,

Xu,

Xia

et al. 2024

Sci Rep

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This study evaluated retinal and choroidal microvascular changes in night shift medical workers and its correlation with melatonin level. Night shift medical workers (group A, 25 workers) and non-night shift workers (group B, 25 workers) were recruited. The images of macula and optic nerve head were obtained by swept-source OCT-angiography. Vessel density of retina, choriocapillaris (CC), choriocapillaris flow deficit (CC FD), choroidal thickness (CT) and choroidal vascularity index (CVI) were measured. 6-sulfatoxymelatonin concentration was analyzed from the morning urine. CC FD and CVI were significantly decreased and CT was significantly increased in group A (all P < 0.05). 6-sulfatoxymelatonin concentration was significantly lower in group A (P < 0.05), which was significantly positively correlated with CC FD size (r = 0.318, P = 0.024) and CVI of the most regions (maximum r-value was 0.482, P < 0.001), and was significantly negatively associated with CT of all regions (maximum r-value was − 0.477, P < 0.001). In night shift medical workers, the reduction of melatonin was significantly correlated with CT thickening, CVI reduction and CC FD reduction, which suggested that they might have a higher risk of eye diseases. CC FD could be a sensitive and accurate indicator to reflect CC perfusion.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Assessment of retinal and choroidal microvasculature in night shift medical workers by OCT angiography

Liang,

Xu,

Xia

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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“…[35,[86][87][88][89] Many researchers have integrated diverse data sources, including fundus images, clinical data, genomic information, and extensive long-term monitoring data, to build predictive models for forecasting the occurrence, progression, and treatment response of DME. [90][91][92][93][94][95] Personalized treatment plans based on deep learning have also attracted considerable attention. Analyzing large-scale clinical data and establishing models to provide customized, individualized treatment plans for each patient can improve treatment outcomes.…”

Section: Emerging Research Areasmentioning

confidence: 99%

Global research trends and future directions in diabetic macular edema research: A bibliometric and visualized analysis

Li,

Jie,

Wang

et al. 2024

Medicine

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Background: Diabetic Macular Edema (DME) significantly impairs vision in diabetics, with varied patient responses to current treatments like anti-vascular endothelial growth factor (VEGF) therapy underscoring the necessity for continued research into more effective strategies. This study aims to evaluate global research trends and identify emerging frontiers in DME to guide future research and clinical management. Methods: A qualitative and quantitative analysis of publications related to diabetic macular edema retrieved from the Web of Science Core Collection (WoSCC) between its inception and September 4, 2023, was conducted. Microsoft Excel, CiteSpace, VOSviewer, Bibliometrix Package, and Tableau were used for the bibliometric analysis and visualization. This encompasses an examination of the overall distribution of annual output, major countries, regions, institutions, authors, core journals, co-cited references, and keyword analyses. Results: Overall, 5624 publications were analyzed, indicating an increasing trend in DME research. The United States was identified as the leading country in DME research, with the highest h-index of 135 and 91,841 citations. Francesco Bandello emerged as the most prolific author with 97 publications. Neil M. Bressler has the highest h-index and highest total citation count of 46 and 9692, respectively. The journals “Retina – the Journal of Retinal and Vitreous Diseases” and “Ophthalmology” were highlighted as the most prominent in this field. “Retina” leads with 354 publications, a citation count of 11,872, and an h-index of 59. Meanwhile, “Ophthalmology” stands out with the highest overall citation count of 31,558 and the highest h-index of 90. The primary research focal points in diabetic macular edema included “prevalence and risk factors,” “pathological mechanisms,” “imaging modalities,” “treatment strategies,” and “clinical trials.” Emerging research areas encompassed “deep learning and artificial intelligence,” “novel treatment modalities,” and “biomarkers.” Conclusion: Our bibliometric analysis delineates the leading role of the United States in DME research. We identified current research hotspots, including epidemiological studies, pathophysiological mechanisms, imaging advancements, and treatment innovations. Emerging trends, such as the integration of artificial intelligence and novel therapeutic approaches, highlight future directions. These insights underscore the importance of collaborative and interdisciplinary approaches in advancing DME research and clinical management.

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Comment on Choriocapillaris flow deficit as a biomarker for diabetic retinopathy and diabetic macular edema: 3-year longitudinal cohort

Govindaraj¹,

Selvister²,

Anand³

2023

American Journal of Ophthalmology

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Choriocapillaris Flow Deficit as a Biomarker for Diabetic Retinopathy and Diabetic Macular Edema: 3-Year Longitudinal Cohort

Cited by 9 publications

References 49 publications

Assessment of retinal and choroidal microvasculature in night shift medical workers by OCT angiography

Assessment of retinal and choroidal microvasculature in night shift medical workers by OCT angiography

Global research trends and future directions in diabetic macular edema research: A bibliometric and visualized analysis

Comment on Choriocapillaris flow deficit as a biomarker for diabetic retinopathy and diabetic macular edema: 3-year longitudinal cohort

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