Longevity‐associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men

Abstract

Longevity-associated mitochondrial DNA 5178 A/C polymorphism may be associated with IOP in Japanese men.

NACH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modifies the Effects of Alcohol Consumption on Risk for Hypertension in Middle-Aged Japanese Men

“…Previous studies have found that both SBP and DBP were lower in non-drinkers with ND2-237Leu than in those with ND2-237Met (7), and that serum uric acid levels were lower in non-obese non-daily drinkers with ND2-237Leu than in those with ND2-237Met (11). Only among men with ND2-237Leu, habitual drinking was reportedly and positively associated with intraocular pressure (21). Therefore, abstaining from alcohol consumption, or at least avoiding daily alcohol consumption, is particularly recommended for ND2-237Leu genotypic men in order to lower the risk of lifestyle-related diseases.…”

“…We previously reported that longevity-associated ND2-237 Leu/Met polymorphism modulates the effects of habitual alcohol drinking on blood pressure (7), serum triglyceride levels (9), serum uric acid levels (11) and intraocular pressure (21). Habitual alcohol consumption influences the production of ROS by NADH dehydrogenase (22), and modifies the susceptibility of mitochondrial proteins, including NADH dehydrogenase, to ROS (23).…”

“…Although we have also used this evaluation in previous reports (7,9,10,21), whether there is any interaction between ND2-237 Leu/Met polymorphism and volume of alcohol intake on risk of hypertension warrants further investigation. Recently, interactions between the angiotensinogen gene and adducing gene (27) and between the serotonin 2A receptor gene and endothelin-1 gene (28) have been reported to be associated with hypertension in Japanese.…”

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

“…We have discovered gene-environment interactions between Mt5178 C/A polymorphism and smoking habits for serum triglyceride levels (Kokaze et al 2003a), intraocular pressure (Kokaze et al 2004b), hematological data (Kokaze et al 2005b), serum protein fraction levels (Kokaze et al 2003b), and, in this study, FEV 1 /FVC ratio. The precise mechanisms through which Mt5178 C/A polymorphism exerts its interaction with habitual smoking, and thereby affects biophysical and biochemical status, are unknown.…”

“…The frequency of the Mt5178A genotype, a genetic marker of mitochondrial haplogroup D, is significantly higher in Japanese centenarians than in the general population (Alexe et al 2007;Tanaka et al 1998) and it is reported that individuals with Mt5178A (mitochondrial haplogroup D) are less susceptible to lifestyle-related adult-onset diseases, for example hypertension (Kokaze et al 2007), diabetes (Wang et al 2001), metabolic syndrome ), myocardial infarction (Mukae et al 2003;Takagi et al 2004), and cerebrovascular diseases (Ohkubo et al 2002), than those with Mt5178C. Mt5178 C/A polymorphism is, moreover, also reported to be associated with blood pressure (Kokaze et al 2004a(Kokaze et al , 2007, serum lipid levels (Kokaze et al 2001(Kokaze et al , 2003a, fasting plasma glucose levels and glucose tolerance (Kokaze et al 2005a), serum uric acid levels (Kokaze et al 2006), intraocular pressure (Kokaze et al 2004b), hematological data (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2002(Kokaze et al , 2003b, and its interaction with smoking habits is associated with serum triglyceride levels (Kokaze et al 2003a), intraocular pressure (Kokaze et al 2004b), red blood cell counts (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2003b). As far as we are aware, however, no information is available about the relationship between Mt5178 C/A polymorphism and respiratory function or about its interaction with smoking habits in respiratory function.…”