Longer Duration of Untreated Psychosis Hinders Improvement in Treatment of Chronic Schizophrenia: Community Based Early Intervention is an Evidence Based Option

Tabo, Abdulkadi̇r; Aydın, Erkan; Yumrukçal, Hüseyin; Yiğit, Sadık; Uzun, U.; Karamustafalıoğlu, Oğuz

doi:10.1007/s10597-017-0088-9

Cited by 4 publications

(4 citation statements)

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“…To summarize, our results underline the necessity of offering community-based psychosocial treatments beside antipsychotic pharmacological treatments ( 33 , 67 ). Community-based psychosocial treatments supporting the richness of interpersonal network and social support is a crucial part of the complex therapy of schizophrenia.…”

Section: Discussionmentioning

confidence: 69%

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

et al. 2018

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Schizophrenic patients have serious impairments in social cognition, which often persists after significant reduction in clinical symptoms. Community-based psychosocial treatments aim to recover social functioning for mentally ill individuals. Our aim was to examine prospective changes in social cognition and functional outcomes in two groups of schizophrenic patients involved in two forms of community-based psychosocial treatments namely case management (CM) and community-based club (CC) compared to a matched, treatment as usual (TAU) group of patients. We hypothesized that CC and CM groups would exhibit better functional and social cognitive outcomes after a 6-month long psychosocial treatment period. Seventy-five patients participated either in CC, CM or TAU. Both CC and CM took part in community-based psychosocial treatment programs including trainings, such as communication and assertiveness trainings. In addition, CC provided group therapeutic treatments and a continuously available day care where patients had the possibility to participate in various social interactions. All participants were in remission, and on maintenance antipsychotic treatment. Participants were assessed on all study variables at two time points: baseline and after 6 months with a battery of questionnaires that examined affective face perception, affective prosody perception, pragmatic language comprehension and ToM. Our results showed that functional outcomes improved significantly in the CC as well as in the CM groups, in contrast to the TAU group. While analyzing summary scores of social cognition, it was found that only the CC group increased its performance in social cognition. In addition, a significant between-group difference in social cognitive function was found after 6 months between the three groups, with the CC group performing best. When investigating associations between changes in social cognition and changes in functional outcomes during a 6-month long treatment period, we found significant correlations between the two variables both in the CC and in the CM groups. Based on our results, we suggest that a rich interpersonal network and social support have highly beneficial effects on social cognition and we would like to emphasize the necessity of offering community-based psychosocial treatments beside antipsychotic medications as early as possible as a crucial part of the complex therapy of schizophrenia.

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Section: Discussionmentioning

confidence: 69%

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

et al. 2018

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“…In the present study, we found that DUP was positively correlated with the PANSS negative scale, and longer DUP with severe negative symptoms in schizophrenic patients treated for more than 2 years. Kanahara et al identified that DUP was associated with greater negative symptoms and decreased functioning, but not with positive symptoms ( 27 ), at the same time, several studies also demonstrated that longer DUP hindered the improvement in PANSS negative, general subscales and total score in chronic SCZ ( 30 – 32 ). These findings also supported our results, especially showing increases in negative symptoms.…”

Section: Discussionmentioning

confidence: 98%

Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia

Tan²,

Wang³

et al. 2023

Front. Psychiatry

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ObjectiveTo explore the relationship between the Duration of Untreated Psychosis (DUP) and long-term clinical outcome, cognitive and social function in patients with chronic schizophrenia (SCZ).MethodsA total of 248 subjects with chronic SCZ were enrolled in this study, including 156 in the short DUP group and 92 in the long DUP group. The Positive and Negative Symptoms Scale (PANSS), the Brief Negative Symptoms Scale (BNSS), the Global Assessment of Functioning (GAF) scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) were used to assess all of the subjects.ResultsThe negative symptom scores (the PANSS and BNSS) of subjects with long DUP were significantly higher than that in subjects with short DUP. The scores of visual span and speech function in the short DUP group were significantly higher, indicative of decreasing cognitive function with time. In terms of social function, the short DUP group scored higher, with a statistically significant difference. Meanwhile, we found that the length of DUP was positively correlated with the negative symptom score of the PANSS, negatively correlated with visual span scores, and GAF scores.ConclusionThis study demonstrated that the DUP remained a significant association with negative symptom and cognition in long period of chronic SCZ.

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“…Pérez Fuentes MDC [41] found that family function scores were higher in nonaggressive subjects than in attackers. Moreover, domestic and foreign studies have found that the factors affecting aggressive behaviour in schizophrenia mainly include individual factors and family social factors [41,42].…”

Section: The Regulatory Role Of Family Intimacy and Adaptability Betw...mentioning

confidence: 99%

The relationship between sleep disorders and aggressive behaviour among schizophrenia patients in the community: A moderated mesomeric effect model

Ye,

Wu,

Yue

et al. 2023

Preprint

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Objective Sleep disorder is the most common complaint of patients with schizophrenia, which can not only lead to poor prognosis and low survival rate but also aggressive behaviour, posing a significant threat to social security and stability. The aim of this study is to explore the mediating role of depression in the relationship between sleep disorders and aggressive behaviour in people with schizophrenia living in the community, as well as the regulatory role of family intimacy and adaptability. These findings, in turn, may provide a theoretical basis and constructive suggestions for resolving the physical and mental health problems of these patients.Method A convenience sampling method was used to select schizophrenia patients from Pengzhou City, China, for follow-up, and a survey was conducted on the Questionnaire Star platform. The survey included questions about general demographic data and disease-related questionnaires: the Pittsburgh Sleep Quality Index (PSQI), the Modified Over Aggression Scale (MOAS) revised Chinese version, the Self-Rating Depression Scale (SDS), and the Family Adaptability and Cohesion Scale, Second Edition. FACES-II and SPSS 21.0 were used to organize and analyse the data.Results A total of 818 schizophrenia patients living in the community participated in the survey, and 785 valid questionnaires were ultimately collected for a response rate of 95.97%. The results of multivariate analysis indicate that gender, psychiatric medication use, outpatient follow-up, and sleep disorders are the factors influencing aggressive behaviour. Depression played a partial mediating role between sleep disorders and aggressive behaviour, and the indirect effect size value was 0.043 (57.33% of the total). Sleep disorders and family intimacy (β=-0.009, P < 0.01) and adaptability (β=-0.145, P < 0.001) can significantly predict depression.Conclusion 1. The incidence of aggressive behaviour and sleep disorders in patients with schizophrenia living in the community is low. 2. Depression plays a partial mediating role in the relationship between sleep disorders and aggressive behaviour. 3. Family intimacy and adaptability play a regulatory role between depression and sleep disorders.

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Longer Duration of Untreated Psychosis Hinders Improvement in Treatment of Chronic Schizophrenia: Community Based Early Intervention is an Evidence Based Option

Cited by 4 publications

References 25 publications

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

Community-Based Psychosocial Treatment Has an Impact on Social Processing and Functional Outcome in Schizophrenia

Correlation between duration of untreated psychosis and long-term prognosis in chronic schizophrenia

The relationship between sleep disorders and aggressive behaviour among schizophrenia patients in the community: A moderated mesomeric effect model

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