Long-Term Use of Probiotic-Containing Yogurts Is a Safe Way to PreventHelicobacter pylori: Based on a Mongolian Gerbil's Model

Abstract

Background. The suppression of Helicobacter pylori (H. pylori) decreases H. pylori-related diseases. The probiotics have an inhibitory effect on H. pylori. Aim. We investigated the effects of long-term use of yogurt on H. pylori based on Mongolian gerbils' model. Materials and Methods. Yogurt (containing a supplement of Lactobacillus acidophilus, Bifidobacterium lactis, etc.) was used. Forty-six gerbils were divided into five groups. All groups were inoculated with H. pylori for 5 to 8 weeks. The yogurt was given as follows: Group (Gr.) A: from 1st to 4th week; Gr. B from 5th to 8th week; Gr. C: from 17th week to sacrifice; Gr. D: from 5th week to sacrifice. Gerbils were sacrificed on the 52nd week. Histology was evaluated according to the Sydney system. Results. The positive rates of H. pylori were 60% (Gr. A), 75% (Gr. B), 67% (Gr. C), 44% (Gr. D), and 100% (Gr. E). Gr. D showed lower inflammatory score. Only Gr. E (60%) had intestinal metaplasia. Gr. D showed higher IL-10 and lower TNF-α expression than Gr. E. Conclusion. Long-term intake of yogurt could decrease H. pylori infection. The long-term use of yogurt would be an alternative strategy to manage H. pylori infection.

Probiotics and Their Potential Preventive and Therapeutic Role for Cancer, High Serum Cholesterol, and Allergic and HIV Diseases

“…For example, several Gram-positive probiotic can synthesize antimicrobial peptides, acetic, lactic, and propionic acid which reduce the intestinal pH and consequently inhibit the growth of several pathogenic Gram-negative bacteria [ 87 ]. These data were further supported by several other studies [ 88 – 90 ] which showed that several strains of lactobacilli have antagonistic activities against Gram-negative gastric-cancer-related Helicobacter pylori . Furthermore, another study found that some Lactobacillus strains produce lactic acid which inhibits the growth of Salmonella enterica [ 91 ].…”

Emerging Role of Probiotics in the Management of Helicobacter Pylori Infection: Histopathologic Perspectives

“…The yogurt was given mixed with drinking water. The scarified jerbils showed lower inflammatory score on histopathologic examination parallel to the lower H. pylori colonization rates reported among study groups .…”

“…Although improvements in H. pylori‐ induced gastritis were noticed with different antibiotics used in H. pylori eradication , probiotics‐associated improvements in the histopathologic changes have particular importance due to various aspects. The effect is probably long lasting compared with the relatively short effect of antibiotics , and this may be due to its impact on the gut barriers and immunity . Once the drug is stopped, H. pylori ‐associated inflammation returns to pretreatment levels , while improvements after stoppage of probiotics were documented months later .…”

Encapsulation of Lactic Acid Bacteria by Lyophilisation with Its Effects on Viability and Adhesion Properties

“…Thus, many drying techniques are employed to sustain the CFU g −1 value making it suitable for long-term storage [ 12 ].The spray drying method is found to be a most favourable technique to generate LAB granules. Spray drying yoghurt to preserve Lactobacillus and dairy starter cultures has been long investigated [ 13 ]. Lyophilised and spray-dried probiotic cultures are found to be stable with long-term storage life as compared to tray dry or other methods [ 14 ].…”