Long-term Use of Phenylbutazone in Rheumatoid Arthritis

Drug Treatment of Rheumatic Disorders in General Practice. A Comparative Study of Aspirin and an Alkali‐Phenylbutazone Preparation

“…Mason and Steinberg (1960) reported 10% of patients developing gastric intolerance leading to withdrawal of treatment in up to 3 years of therapy, though the majority occurred during the early phases of treatment. Meanock and Lewis‐Faning (1961) in a double‐blind trial reported that 10 of 53 patients with rheumatoid arthritis had gastric side‐effects with phenylbutazone.…”

A Double‐blind Crossover Trial comparing a New Antirheumatic Agent Alclofenac with Phenylbutazone in Chronic Rheumatic Disorders

“…Phenylbutazone was chosen as the drug of comparison since it has been used effectively as an acceptable analgesic-antiinflammatory drug in the treatment of chronic rheumatic diseases even though adverse reactions, in particular gastrointestinal side-effects, occur in 10-20% of patients treated (Meanock and Lewis-Faning, 1961; Mason and Steinberg, 1960; Rushford and Fowler, 1970).…”