A Double‐blind Crossover Trial comparing a New Antirheumatic Agent Alclofenac with Phenylbutazone in Chronic Rheumatic Disorders

Aylward, Mansel; Davies, D B

doi:10.1111/j.1742-1241.1972.tb05065.x

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1975

1979

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Cited by 9 publications

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A Dual Approach to the Evaluation of the Efficacy of a New Rheumatoid Arthritic Agent—Pirprofen

Maggio‐Cavaliere

Bonus

Gum

1976

The Journal of Clinical Pharma

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Pirprofen was compared to placebo in a double-blind crossover study in 12 rheumatoid arthritis patients. Two approaches--univariate and multivariate--were used to analyze the study results which were in the form of arithmetic changes from pretreatment levels of six efficacy measurements. The univariate analysis failed to permit a single decision to be made regarding the further investigation and use of pirprofen in rheumatoid arthritis. However, the multivariate analysis which treats the efficacy variables simultaneously showed a clear differentation from placebo. Thus, multivariate analysis enabled the clinical pharmacologist to evaluate the new therapeutic agent in a complete and comprehensive manner. It allowed for a single decision to be made regarding the merits of pirprofen compared to placebo.

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