2010
DOI: 10.1007/s00228-010-0880-8
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Long-term use of fluoxetine and multiple skeleton fractures

Abstract: Dear Editor:We report a 33-year-old female patient treated with fluoxetine for 8 years for depression.She had the first depression attack 14 years ago. She was treated with fluoxetine 20 mg/day and used that dose continuously for 5 years. After quitting the medication, her depression returned and fluoxetine was begun at 20 mg/day and increased to 40 mg/day and used at that dose for 3 months, than lowered to the original dose. At the end of 8 years of using fluoxetine 20 mg/day, three fractures occured within a… Show more

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Cited by 5 publications
(2 citation statements)
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“…Clinical reports of greater risk for bone fracture have been associated with the use of SSRI (Richards et al, 2007;Vestergaard et al, 2008;Ceylan and Maner, 2010). Moreover, the degree of bone mineralization (Renders et al, 2007) and mandibular cortex thickness have an influence on bone radiopacity (Khojastehpour et al, 2011).…”
Section: Discussionmentioning
confidence: 97%
“…Clinical reports of greater risk for bone fracture have been associated with the use of SSRI (Richards et al, 2007;Vestergaard et al, 2008;Ceylan and Maner, 2010). Moreover, the degree of bone mineralization (Renders et al, 2007) and mandibular cortex thickness have an influence on bone radiopacity (Khojastehpour et al, 2011).…”
Section: Discussionmentioning
confidence: 97%
“…Antidepressants are safe for short-term use. However, prolonged use can cause side effects with previously undetected clinical risks 1). We report a case of a patient in whom levels of carcinoembryonic antigen (CEA) in blood increased greatly while using escitalopram but decreased after the drug was discontinued.…”
mentioning
confidence: 96%