Effects of treatment with fluoxetine on mandibular development: A morphological study in rats

Marcelos, Priscylla Gonçalves Correia-Leite de; Regueira, Luciana Silva; Santiago-Jaegger, Isabela Maria; Perez, Danyel Elias Cruz; Ramos‐Perez, Flávia Maria de Moraes; Neto, Joaquim Evêncio; Baratella-Evêncio, Liriane

doi:10.1016/j.acthis.2015.05.005

Cited by 7 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with our finding of a detrimental impact on developing long bone, fluoxetine exposure to pregnant and lactating rats inhibited mandibular development in pups 15 and reduced whole-body and hindlimb bone mineral accrual in young, growing pups 10 . By the time of parturition, a fetus has formed 98% of its skeleton 16 .…”

Section: Discussionsupporting

confidence: 91%

In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning

Weaver

Xie

Charles

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Selective Serotonin Reuptake Inhibitors (SSRIs) such as fluoxetine are widely prescribed to pregnant and breastfeeding women, yet the effects of peripartum SSRI exposure on neonatal bone are not known. In adult populations, SSRI use is associated with compromised bone health, and infants exposed to in utero SSRIs have a smaller head circumference and are shorter, suggesting possible effects on longitudinal growth. Yet no study to date has examined the effects of peripartum SSRIs on long bone growth or mass. We used microCT to determine the outcomes of in utero and lactational SSRI exposure on C57BL6 pup bone microarchitecture. We found that peripartum exposure to 20 mg/kg fluoxetine reduced femoral bone mineral density and bone volume fraction, negatively impacted trabecular and cortical parameters, and resulted in shorter femurs on postnatal day 21. Although SSRIs are considered the first-choice antidepressant for pregnant and lactating women due to a low side effect profile, SSRI exposure may compromise fetal and neonatal bone development.

show abstract

Section: Discussionsupporting

confidence: 91%

In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning

Weaver

Xie

Charles

et al. 2019

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Nevertheless, the administration of 20 mg/kg fluoxetine during rat pregnancy and lactation modified the jawbone mass of the pups 8 . Taking these results into consideration, besides the fact that the dose most used in humans is 20 mg/kg, we opted to conduct our study using the 20 mg/kg dose.…”

Section: Discussionmentioning

confidence: 99%

Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats

et al. 2017

Self Cite

View full text Add to dashboard Cite

Reports have indicated that serotonin plays an important role in cell migration and differentiation during the organogenesis of several tissues, including the oral types. Administration of selective serotonin reuptake inhibitor (SSRI) drugs during pregnancy could affect the delivery of serotonin to embryonic tissues altering its development. Objective This study aimed to assess the effects of fluoxetine, a selective serotonin reuptake inhibitor, on the formation of the periodontal ligament during pregnancy and lactation in rat pups.Material and Methods Twelve pregnant rats of Wistar lineage were divided into four study groups. In the control group, 0.9% sodium chloride solution was administered orally, throughout the entire period of the 21 days of pregnancy (CG group) and in the CGL group, it was administrated during pregnancy and lactation (from day 1 of pregnancy to the 21st day after birth). Fluoxetine was administered orally at the dose of 20 mg/kg in a group treated during pregnancy only (FG group), and during pregnancy and lactation (FGL group). Histometrical, histochemical and immunohistochemical analysis of the maxillary first molar periodontium region of the 24 rat pups was made under light microscopy, and periodontal ligament collagen was qualitatively evaluated under a polarizing light microscope.Results The quantity of fibroblasts (p=0.006), osteoblasts (p=0.027) and cementoblasts (p=0.001) was reduced in pups from the rats that received fluoxetine during pregnancy and lactation. No alterations were seen in the collagen fibers.Conclusion These findings suggest that periodontal tissue may be sensitive to fluoxetine, and its interference in reducing periodontal cells depends on exposure time during lactation.

show abstract

“…In both models, SERT inhibition resulted in a reduction in bone accrual [ 244 ]. When rat dams were orally dosed with 20 mg/kg, their offspring displayed differences in the mandibular bone, including reduction of osteocyte number and reduction in bone density [ 245 ]. However, it is important to note that most of the mandible is formed via intramembranous ossification, which is a different process than endochondral ossification [ 246 ].…”

Section: Early Development and Fetal Programmingmentioning

confidence: 99%

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

Fricke

Hernández

2023

J Mammary Gland Biol Neoplasia

View full text Add to dashboard Cite

Lactation is a physiological adaptation of the class Mammalia and is a product of over 200 million years of evolution. During lactation, the mammary gland orchestrates bone metabolism via serotonin signaling in order to provide sufficient calcium for the offspring in milk. The role of serotonin in bone remodeling was first discovered over two decades ago, and the interplay between serotonin, lactation, and bone metabolism has been explored in the years following. It is estimated that postpartum depression affects 10–15% of the population, and selective serotonin reuptake inhibitors (SSRI) are often used as the first-line treatment. Studies conducted in humans, nonhuman primates, sheep, and rodents have provided evidence that there are consequences on both parent and offspring when serotonin signaling is disrupted during the peripartal period; however, the long-term consequences of disruption of serotonin signaling via SSRIs during the peripartal period on the maternal and offspring skeleton are not fully known. This review will focus on the relationship between the mammary gland, serotonin, and bone remodeling during the peripartal period and the skeletal consequences of the dysregulation of the serotonergic system in both human and animal studies.

show abstract

Effects of treatment with fluoxetine on mandibular development: A morphological study in rats

Cited by 7 publications

References 38 publications

In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning

In utero and lactational exposure to the Selective Serotonin Reuptake Inhibitor fluoxetine compromises pup bones at weaning

Fluoxetine effects on periodontogenesis: histomorphometrical and immunohistochemical analyses in rats

The Serotonergic System and Bone Metabolism During Pregnancy and Lactation and the Implications of SSRI Use on the Maternal-Offspring Dyad

Contact Info

Product

Resources

About