Long-term urodynamic findings following radical prostatectomy and salvage radiotherapy

Ervandian, Maria; Djurhuus, Jens Christian; Høyer, Morten; Graugaard-Jensen, Charlotte; Borre, Michael

doi:10.1080/21681805.2017.1354067

Cited by 9 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, radiotherapy following prostatectomy can cause obliterative endarteritis, tissue necrosis and fibrosis, resulting in VUAS or urethral stricture 41,42 . In a small series of men treated with salvage radiotherapy following RP, a high rate of BOO (43.8%) was found following both treatments 17 …”

Section: Discussionmentioning

confidence: 99%

“…41,42 In a small series of men treated with salvage radiotherapy following RP, a high rate of BOO (43.8%) was found following both treatments. 17 Transurethral resection of the prostate (TURP) and Holmium laser enucleation of the prostate improves symptoms of OAB in the majority of patients by relieving BOO. 43,44 Despite relieving BOO, OAB can be persistent in 20%-38% of men even after a year following TURP.…”

Section: Maximum Cystometric Capacity (Mcc)mentioning

confidence: 99%

See 1 more Smart Citation

Impact of radical prostatectomy on bladder function as demonstrated on urodynamics study—A systematic review

Yao

Hoe

Crump

et al. 2021

Neurourology and Urodynamics

View full text Add to dashboard Cite

Aims: This study aims to describe the effects of radical prostatectomy (RP) on bladder function by performing a systematic review of urodynamics study findings before and after RP. Methods: This systematic review was conducted in accordance with the PRISMA guideline and registered on PROSPERO (CRD42020206844). A systematic search was conducted using PubMed, Cochrane, and Embase. Studies were included if they involved men who underwent RP and had urodynamics study performed preoperatively, postoperatively, or both. Studies that included only subgroups of patients based on symptoms were excluded. Three hundred and four articles were screened, with 20 articles included. A qualitative analysis was performed. Results: The rate of baseline bladder outlet obstruction (BOO) pre-RP was 19%-67%. All six studies with comparative data pre-and postoperatively demonstrated a decrease in the rate of patients with equivocal or clear obstruction. The baseline rates of detrusor overactivity (DO) varied widely from 11% to 61.2%. Six of eight studies with 6 months or more follow-up showed an improvement in the rates of DO ranging from 3.0% to 12.5%. The rate of de novo DO ranged from 0% to 54.5%. Four studies reported an increased rate of impaired bladder contractility and two of three studies showed a worsening rate of impaired bladder compliance following RP. This review is limited by the absence of level I/II studies. Conclusions: Urodynamics study shows that BOO is improved following RP in most patients. RP resolves DO in some patients and cause de novo DO in others. The net effect is a reduced overall rate of DO in most studies. Bladder compliance and contractility may be impaired after RP.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Maximum Cystometric Capacity (Mcc)mentioning

confidence: 99%

Impact of radical prostatectomy on bladder function as demonstrated on urodynamics study—A systematic review

Yao

Hoe

Crump

et al. 2021

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…Radiotherapy after radical prostatectomy has been shown to worsen LUTS and QOL 17 . Miyake et al 18 reported the deterioration of storage symptoms, especially frequency, after salvage radiotherapy and Ervandian et al 19 worsened LUTS along with long‐term deterioration of several urodynamic parameters after salvage radiotherapy. These might explain the current results of the insignificant improvement of IPSS soon after AUS implantation and the significantly worsening trend of IPSS in the patients receiving radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal changes in patient‐reported outcomes after artificial urinary sphincter implantation

Yokoyama

Masuda

Ito

et al. 2020

LUTS

View full text Add to dashboard Cite

Objective To evaluate the time course of lower urinary tract symptoms (LUTS) after artificial urinary sphincter (AUS) implantation based on individual longitudinal changes of patient‐reported outcomes. Methods This retrospective study included 66 male patients with severe urinary incontinence who were treated with primary AUS implantation between 2009 and 2019. International Consultation on Incontinence Questionnaire‐Short Form (ICIQ‐SF) and International Prostate Symptom Score (IPSS) questionnaires were used to evaluate continence status and LUTS preoperatively, 1, 3, and 12 months after activation, and then annually. The annual changes in scores were calculated with a linear mixed model. Results Of the 66 patients, 63 (95%) achieved complete or social continence (number of pads used ≤1/d) at 1 month after activation. Mean preoperative ICIQ‐SF, IPSS, and IPSS‐quality of life (QOL) score were 18.9, 14.9, and 5.4, respectively; the corresponding scores at 1 month after activation were 4.5, 9.0, and 1.7 (all P < .001), respectively. During the mean follow‐up period of 36 months, the annual changes in the scores from 1 month after activation were 0.51 (P = .002), −0.30 (P = .184), and 0.19 (P < .001), respectively. As for individual IPSS items, while incomplete emptying, frequency, urgency, and weak stream improved significantly 1 month after activation, no significant changes from 1 month after activation were observed except for longitudinal deterioration of incomplete emptying score (0.08/y, P = .029). Conclusion Continence status and QOL score markedly improved by AUS implantation immediately, but deteriorated over time. Improved LUTS were maintained without a worsening trend, however.

show abstract

“…After removing 75 duplicates, 723 articles were screened against title and abstract and 19 articles assessed for full-text eligibility. Five of the nineteen articles were eligible to be included in the final review [7][8][9][10][11] . Reasons for exclusion are listed in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…One study involved patients with primary curative radiotherapy only 7,8 . Another study included patients following salvage radiotherapy following RP 9 . The final study included patients following adjuvant radiotherapy and compared with patients who underwent RP alone as control 11 .…”

Section: Baseline Demographicsmentioning

confidence: 99%

Impact of radiotherapy for localized prostate cancer on bladder function as demonstrated on urodynamics study: A systematic review

Yao

Hoe

Shamout

et al. 2021

CUAJ

View full text Add to dashboard Cite

Introduction: This study aimed to describe the effects of bladder function following radiotherapy for localized prostate cancer by performing a systematic review on studies reporting on urodynamic findings after radiotherapy. Methods: This systematic review was conducted in accordance with PRISMA guidelines. The review protocol was registered at PROSPERO (CRD42021229037). A systematic search was conducted using PubMed, Cochrane Library, Scopus, and OVID Embase. Studies were included if they involved men who underwent urodynamic studies following radiotherapy for localized prostate cancer. A total of 798 articles were screened and five articles included. A qualitative analysis was performed. Results: Bladder compliance appears to be impaired following radiotherapy, especially with longer followup. Impaired bladder compliance was reported in 18.8–62.5% of patients following radiotherapy. Bladder capacity was found to be statistically significantly lower following radiotherapy compared to pre-radiotherapy, and when compared with patients who did not undergo pelvic radiotherapy. Bladder outlet obstruction (BOO) persists post-radiotherapy in most patients at three and 18 months post-radiotherapy. De novo detrusor overactivity (DO) of 13.3% has been reported at 18 months post-radiotherapy. This review is limited by the absence of level I/II studies. Conclusions: Radiotherapy for localized prostate cancer results in decreased bladder compliance and capacity demonstrated on urodynamic studies. Resolution of BOO appears less likely in comparison to series on radical prostatectomy. De novo DO may develop following radiotherapy, especially with longer followup. With only low level of evidence studies available at present, further high-quality, prospective studies are important to elucidate the impact of radiotherapy on bladder and urethral function.

show abstract

Long-term urodynamic findings following radical prostatectomy and salvage radiotherapy

Cited by 9 publications

References 26 publications

Impact of radical prostatectomy on bladder function as demonstrated on urodynamics study—A systematic review

Impact of radical prostatectomy on bladder function as demonstrated on urodynamics study—A systematic review

Longitudinal changes in patient‐reported outcomes after artificial urinary sphincter implantation

Impact of radiotherapy for localized prostate cancer on bladder function as demonstrated on urodynamics study: A systematic review

Contact Info

Product

Resources

About