Long-term urine biobanking: Storage stability of clinical chemical parameters under moderate freezing conditions without use of preservatives

Remer, Thomas; Montenegro-Bethancourt, Gabriela; Shi, Lijie

doi:10.1016/j.clinbiochem.2014.09.009

Cited by 62 publications

(39 citation statements)

References 34 publications

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“…Aliquots of 24-hour urine and spot samples were stored preservative free at -22°C in the urine bank of the DONALD Study. All 24-hour urine and spot urine samples were analyzed at the laboratory of the DONALD Study, following the overall study protocol (20). Iodine concentration (lg/L) was determined by a modified Sandell-Kolthoff method after acid wet-washing of the samples (20,21).…”

Section: Urine Sampling and Analysismentioning

confidence: 99%

Iodine Status Assessment in Children: Spot Urine Iodine Concentration Reasonably Reflects True Twenty-Four–Hour Iodine Excretion Only When Scaled to Creatinine

Montenegro-Bethancourt

Johner

Stehle

et al. 2015

Thyroid

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Section: Urine Sampling and Analysismentioning

confidence: 99%

Iodine Status Assessment in Children: Spot Urine Iodine Concentration Reasonably Reflects True Twenty-Four–Hour Iodine Excretion Only When Scaled to Creatinine

Montenegro-Bethancourt

Johner

Stehle

et al. 2015

Thyroid

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“…Osmolality (mosm/kg) was calculated from the freezing-point depression measured by an osmometer (OM 802-D Vogel, Giessen, Germany), analyzed in the laboratory of the DONALD study [15].…”

Section: Urinary Analysismentioning

confidence: 99%

Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment

et al. 2015

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Over 30 % of participants in the two German surveys had an estimated iodine intake less than the respective age-group-specific EAR. Our data strongly suggest that even in large surveys, hydration status can considerably interfere with the epidemiological iodine assessment parameter UIC. The present data can serve as an example how to evaluate population-based spot urine data on a 24-h basis, independent of hydration status.

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“…High long-term stability and measurement validity for numerous clinical chemistry analytes (including creatinine) stored at Ϫ22°C for 12-15 years without addition of any urine preservative has been demonstrated (114 ). For proteome and metabolome analyses, urine storage at room temperature causes progressive degradation of proteins (58 ).…”

Section: Urinementioning

confidence: 99%

Preanalytical Variables Affecting the Integrity of Human Biospecimens in Biobanking

Ellervik

Vaught²

2015

Clinical Chemistry

136

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BACKGROUND Most errors in a clinical chemistry laboratory are due to preanalytical errors. Preanalytical variability of biospecimens can have significant effects on downstream analyses, and controlling such variables is therefore fundamental for the future use of biospecimens in personalized medicine for diagnostic or prognostic purposes. CONTENT The focus of this review is to examine the preanalytical variables that affect human biospecimen integrity in biobanking, with a special focus on blood, saliva, and urine. Cost efficiency is discussed in relation to these issues. SUMMARY The quality of a study will depend on the integrity of the biospecimens. Preanalytical preparations should be planned with consideration of the effect on downstream analyses. Currently such preanalytical variables are not routinely documented in the biospecimen research literature. Future studies using biobanked biospecimens should describe in detail the preanalytical handling of biospecimens and analyze and interpret the results with regard to the effects of these variables.

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Long-term urine biobanking: Storage stability of clinical chemical parameters under moderate freezing conditions without use of preservatives

Cited by 62 publications

References 34 publications

Iodine Status Assessment in Children: Spot Urine Iodine Concentration Reasonably Reflects True Twenty-Four–Hour Iodine Excretion Only When Scaled to Creatinine

Iodine Status Assessment in Children: Spot Urine Iodine Concentration Reasonably Reflects True Twenty-Four–Hour Iodine Excretion Only When Scaled to Creatinine

Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment

Preanalytical Variables Affecting the Integrity of Human Biospecimens in Biobanking

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