Iodine Status Assessment in Children: Spot Urine Iodine Concentration Reasonably Reflects True Twenty-Four–Hour Iodine Excretion Only When Scaled to Creatinine

Montenegro-Bethancourt, Gabriela; Johner, Simone A.; Stehle, Peter; Neubert, Annette; Remer, Thomas

doi:10.1089/thy.2015.0006

Cited by 44 publications

(44 citation statements)

References 26 publications

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“…Urinary iodine is usually expressed as; 1) median urinary iodine concentration or UIC (ug/L) (usually from first morning void urine samples), 2) urinary iodine excretion or UIE from 24 hour urine samples (ug/24-h or ug/day) or 24hr excretion (UIE), or 3) an iodine creatinine ratio (I/Cr x predicted 24hr urine output) (1,44,45). Throughout iodine literature UIC and UIE are used interchangeable, despite the expressions representing different estimates of iodine (44,45).…”

Section: Evaluating and Expressing Urinary Iodinementioning

confidence: 99%

“…Throughout iodine literature UIC and UIE are used interchangeable, despite the expressions representing different estimates of iodine (44,45). The WHO states that provided a sufficient number of spot urine samples are collected from the population, the added burden of collecting 24hr urine samples, especially from young children, is not necessary (1).…”

Section: Evaluating and Expressing Urinary Iodinementioning

confidence: 99%

“…The WHO states that provided a sufficient number of spot urine samples are collected from the population, the added burden of collecting 24hr urine samples, especially from young children, is not necessary (1). Furthermore, there is no validated criterion for appropriate cutoffs describing the varying degrees of iodine status using UIE or I/Cr as an expression, as the estimate can vary between ages, genders and ethnicity (44,45). As UIC is largely influenced by urine volume, which is known to vary day to day, but adjusting for the protein creatinine …”

Section: Evaluating and Expressing Urinary Iodinementioning

confidence: 99%

“…(Cr) (product of muscle metabolism) can reduce the impact of this variation on the interpretation of iodine nutrition (20,44,45). The challenge in correcting for creatinine is that it is influenced by BMI, age, gender and ethnicity and has no validated cut-off criteria for iodine nutrition (20,46).…”

mentioning

confidence: 99%

“…Recently, however, Montenegro-Bethancourt et.al. (2015), reported convincing data to suggest that UIC reasonably reflects actual 24-hr iodine excretion (UIE) but only when corrected for creatinine (45). Whilst the approach of correcting UIC for Cr may yield a more accurate representation of actual 24-hr urinary iodine excretion, for the purpose of a population survey, there remains no validated criteria to appropriately categorise the findings.…”

mentioning

confidence: 99%

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Iodine status of Queensland children and the associations with diet and thyroid function

Samidurai¹

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Section: Evaluating and Expressing Urinary Iodinementioning

confidence: 99%

Section: Evaluating and Expressing Urinary Iodinementioning

confidence: 99%

Section: Evaluating and Expressing Urinary Iodinementioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Iodine status of Queensland children and the associations with diet and thyroid function

Samidurai¹

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Iodine-Induced Thyroid Dysfunction

Leo¹,

Braverman²

2019

The Thyroid and Its Diseases

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Purpose of review-To summarize the mechanisms of iodine-induced hypothyroidism and hyperthyroidism, identify the risk factors for thyroid dysfunction following an iodine load, and summarize the major sources of excess iodine exposure. Recent findings-Excess iodine is generally well tolerated, but individuals with underlying thyroid disease or other risk factors may be susceptible to iodine-induced thyroid dysfunction following acute or chronic exposure. Sources of increased iodine exposure include the global public health efforts of iodine supplementation, the escalating use of iodinated contrast radiologic studies, amiodarone administration in vulnerable patients, excess seaweed consumption, and various miscellaneous sources. Summary-Iodine-induced thyroid dysfunction may be subclinical or overt. Recognition of the association between iodine excess and iodine-induced hypothyroidism or hyperthyroidism is important in the differential diagnosis of patients who present without a known cause of thyroid dysfunction.

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Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment

et al. 2015

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Over 30 % of participants in the two German surveys had an estimated iodine intake less than the respective age-group-specific EAR. Our data strongly suggest that even in large surveys, hydration status can considerably interfere with the epidemiological iodine assessment parameter UIC. The present data can serve as an example how to evaluate population-based spot urine data on a 24-h basis, independent of hydration status.

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Iodine Status Assessment in Children: Spot Urine Iodine Concentration Reasonably Reflects True Twenty-Four–Hour Iodine Excretion Only When Scaled to Creatinine

Cited by 44 publications

References 26 publications

Iodine status of Queensland children and the associations with diet and thyroid function

Iodine status of Queensland children and the associations with diet and thyroid function

Iodine-Induced Thyroid Dysfunction

Examination of iodine status in the German population: an example for methodological pitfalls of the current approach of iodine status assessment

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