Long-term treadmill exercise overcomes ischemia-induced apoptotic neuronal cell death in gerbils

Sim, Young-Je; Kim, Hong; Kim, Jee-Youn; Yoon, SungJin; Kim, Sung Soo; Chang, Hyun‐Kyung; Lee, Taeck-Hyun; Heehyuk, Lee; Shin, Min-Chul; Shin, Mal‐Soon; Kim, Chang‐Ju

doi:10.1016/j.physbeh.2005.02.019

Cited by 61 publications

(74 citation statements)

References 30 publications

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“…The present work shows behavioral and morphological evidence that the unilateral or bilateral encephalic ischemia, with or without reperfusion, causes extensive lesions in striatum, motor cortex and hippocampus, which are structures involved in the organization of motor behavior [11][12][13].…”

Section: Discussionsupporting

confidence: 53%

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Araújo

Bertolino

Gonçalves

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionsupporting

confidence: 53%

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Araújo

Bertolino

Gonçalves

et al. 2012

Journal of the Neurological Sciences

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“…Under neurodegenerative status, treadmill exercise suppressed ischemia-induced increase in DNA fragmentation and caspase-3 expression in the hippocampus and facilitated recovery of short-term memory (Choi et al, 2013; Kim et al, 2014; Sim et al, 2005). …”

Section: Discussionmentioning

confidence: 99%

“…Many studies have reported that exercise improves learning ability and memory function (Choi et al, 2013; Kim et al, 2013; Sim et al, 2005). Physical exercise attenuated and dendritic abnormalities of experimental autoimmune disease (Rossi et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Swimming exercise ameliorates multiple sclerosis-induced impairment of short-term memory by suppressing apoptosis in the hippocampus of rats

Jin¹,

Ko²,

Kim³

et al. 2014

J Exerc Rehabil

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Multiple sclerosis is one of the autoimmune diseases in the central nervous system. Multiple sclerosis occurs through multiple mechanisms, and it is also mediated in part by an apoptotic mechanism. Swimming exercise has been recommended for the prevention and treatment of chronic diseases. In the present study, we investigated the effects of swimming exercise on short-term memory in relation with apoptotic neuronal cell death in the hippocampus following induction of multiple sclerosis. For this study, step-down avoidance task, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, immunohistochemistry for caspase-3 were performed. The animal model of multiple sclerosis was made by bilateral intracerebral ventricle injection of ethidium bromide. The rats in the swimming exercise groups were forced to swim for 30 min once daily for 14 consecutive days, starting 3 days after induction of multiple sclerosis. In the present results, short-term memory was deteriorated in the multiple sclerosis-induced rats. The number of TUNEL-positive and caspase-3-positive cells in the hippocampal dentate gyrus was increased in the multiple sclerosis-induced rats. Swimming exercise alleviated multiple sclerosis-induced short-term memory impairment by suppressing apoptotic neuronal cell death in the hippocampus. These effects of swimming exercise may aid symptom relief in the incurable neurodegenerative diseases.

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“…Physical exercise is known to alleviate memory deficits by aging and neurodegenerative diseases (Kim et al, 2013; Sim et al, 2005). Treadmill running and wheel running are well documented to increase new cell formation and survival in the rodent hippocampus (Kim et al, 2013; van Praag et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer’s disease rats

Sim

2014

J Exerc Rehabil

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Alzheimer’s disease is the most common cause of dementia. This disease is a progressive and irreversible brain disorder accompanied with severe learning and memory impairment. Exercise increases cognitive ability, attenuates motor deficits, increases new neuron formation, and ameliorates neurological impairments in several neurodegenerative diseases. This study investigated the effects of treadmill exercise on spatial learning ability in relation with cell proliferation in the hippocampus. The rat model of Alzheimer’s disease was induced by intracerebroventricular (ICV) injection of streptozotocin (STZ) using a stereotaxic instrument. The rats in the exercise groups were forced to run on a treadmill for once 30 min daily for 28 consecutive days starting at 3 days after the ICV injection of STZ. Radial 8-arm maze test was conducted for the spatial learning ability. New neuron formation in the hippocampus was detected by 5-bromo-2’-deoxyuridine (BrdU) immunohistochemistry. Brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) expressions were examined by western blot analysis. The present results show that ICV injection of STZ impaired spatial learning ability. Decreased cell proliferation with decrement of BDNF and TrkB expressions in the hippocampus were observed in the STZ-induced Alzheimer’s disease rats. However, treadmill exercise alleviated deficits of spatial learning ability. Treadmill exercise enhanced cell proliferation and increased BDNF and TrkB expressions in the rats with ICV injection of STZ. The present study suggests that treadmill exercise can be a useful strategy for treating memory impairment induced by several neurodegenerative diseases.

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Long-term treadmill exercise overcomes ischemia-induced apoptotic neuronal cell death in gerbils

Cited by 61 publications

References 30 publications

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Swimming exercise ameliorates multiple sclerosis-induced impairment of short-term memory by suppressing apoptosis in the hippocampus of rats

Treadmill exercise alleviates impairment of spatial learning ability through enhancing cell proliferation in the streptozotocin-induced Alzheimer’s disease rats

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