Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Araújo, Fernanda Lopes Buiatti de; Bertolino, Guilherme; Gonçalves, Renata Batagini; Marini, Luana de Castro; Coimbra, Norberto Cysne; Araújo, João Luiz Vitorino

doi:10.1016/j.jns.2011.08.019

Cited by 18 publications

(9 citation statements)

References 22 publications

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“…Global cerebral ischemia is known to produce impairments of motor behavior, mainly because of a severe reduction of striatal neurons. 3 In our model, ischemic injuries were also observed in the striatum, which might cause deficits to show in neurological examinations.…”

Section: Discussionmentioning

confidence: 70%

Consistent delayed unilateral neuronal death after modified transient focal cerebral ischemia in mice that mimics neuronal injury after transient global cerebral ischemia

Nishijima¹,

Niizuma²,

Fujimura³

et al. 2015

JNS

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abbreviatioNs BCCAO = bilateral CCA occlusion; CBF = cerebral blood flow; CCA = common carotid artery; DAB = diaminobenzidine; ECA = external carotid artery; ICA = internal carotid artery; LSF = laser speckle flowmetry; MCA = middle cerebral artery; MCAO = MCA occlusion; PBS = phosphate-buffered saline; PCA = posterior cerebral artery; PCoA = posterior communicating artery; rCBF = regional CBF; ROI = region of interest; tGCI = transient global cerebral ischemia; TTC = 2,3,5-triphenyltetrazolium chloride; TUNEL = terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling. submitted April 7, 2014. accepted September 10, 2014. iNclude wheN citiNg Published online February 27, 2015; DOI: 10.3171/2014.9.JNS14778. disclosure The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. The following grant funded this study: JSPS KAKENHI grant no. 24659642. Consistent delayed unilateral neuronal death after modified transient focal cerebral ischemia in mice that mimics neuronal injury after transient global cerebral ischemiayasuo Nishijima, md, phd, Kuniyasu Niizuma, md, phd, miki Fujimura, md, phd, yosuke akamatsu, md, hiroaki shimizu, md, phd, and teiji tominaga, md, phd Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan obJect Numerous studies have attempted to reveal the pathophysiology of ischemic neuronal injury using a representative transient global cerebral ischemia (tGCI) model in rodents; however, most of them have used gerbil or rat models. Recent advances in transgene and gene-knockout technology have enabled the precise molecular mechanisms of ischemic brain injury to be investigated. Because the predominant species for the study of genetic mutations is the mouse, a representative mouse model of tGCI is of particular importance. However, simple mouse models of tGCI are less reproducible; therefore, a more complex process or longer duration of ischemia, which causes a high mortality rate, has been used in previous tGCI models in mice. In this study, the authors aimed to overcome these problems and attempted to produce consistent unilateral delayed hippocampal CA1 neuronal death in mice. methods C57BL/6 mice were subjected to short-term unilateral cerebral ischemia using a 4-mm silicone-coated intraluminal suture to obstruct the origin of the posterior cerebral artery (PCA), and regional cerebral blood flow (rCBF) of the PCA territory was measured using laser speckle flowmetry. The mice were randomly assigned to groups of different ischemic durations and histologically evaluated at different time points after ischemia. The survival rate and neurological score of the group that experienced 15 minutes of ischemia were also evaluated. results Consistent neuronal death was observed in the medial CA1 subregion 4 days after 15 minutes of ischemia in the group of mice with a reduction in rCBF of < 65% in the PCA territory during ischemia. Morphologically degenerated cel...

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Section: Discussionmentioning

confidence: 70%

Consistent delayed unilateral neuronal death after modified transient focal cerebral ischemia in mice that mimics neuronal injury after transient global cerebral ischemia

Nishijima¹,

Niizuma²,

Fujimura³

et al. 2015

JNS

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“…Neurodegeneration in the CA 1 subfield of the hippocampus leads to impaired cognitive function. This injury is due to the reduction of the cell populations in the striatum, motor cortex M 1 area, and hippocampus CA 1 area during BCCAO (Araujo et al, 2012). However, it has also been documented that in middle-aged animals, CA 1 neuronal injury during cerebral global ischemia is accompanied by a 20-25% neuronal loss in the basolateral nucleus of the amygdala and perirhinal cortex ischemia compared to Sham-operated animals (Tremblaye and Plamondon, 2011).…”

Section: Discussionmentioning

confidence: 98%

Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model

et al. 2013

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“…The absence of the posterior communicating artery (PCoA) is found in most gerbils, and the anterior anastomosis of the anterior communicating artery (ACoA) is completely absent in approximately 30%‐40% of the gerbil population . Consequently, ipsilateral ischemic models induced by ligation of the common carotid artery (CCA) in the gerbil neck are widely used in ischemia research . And the contralateral hemisphere could be used as an internal control.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of an ischemic model in ischemia prone and general Mongolian gerbils by neurological symptom, injury, and sex difference

Guo

et al. 2018

Anim Models and Exp Med

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Neuropathology and behavioral impairments after three types of global ischemia surgery in Meriones unguiculatus: Evidence in motor cortex, hippocampal CA1 region and the neostriatum

Cited by 18 publications

References 22 publications

Consistent delayed unilateral neuronal death after modified transient focal cerebral ischemia in mice that mimics neuronal injury after transient global cerebral ischemia

Consistent delayed unilateral neuronal death after modified transient focal cerebral ischemia in mice that mimics neuronal injury after transient global cerebral ischemia

Amelioration of cognitive, motor and endogenous defense functions with silymarin, piracetam and protocatechuic acid in the cerebral global ischemic rat model

Evaluation of an ischemic model in ischemia prone and general Mongolian gerbils by neurological symptom, injury, and sex difference

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