Long-term Survivorship in Lung Cancer

Sugimura, Hiroshi; Yang, Ping

doi:10.1378/chest.129.4.1088

Cited by 148 publications

(131 citation statements)

References 78 publications

(81 reference statements)

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“…Most lung cancer patients are psychologically depressed and exhibit an increased tension-anxiety status compared with the general population before being submitted to operation [196][197][198][199].…”

Section: Residual Function and Qol After Radical Treatmentmentioning

confidence: 99%

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

Brunelli¹,

Charloux²,

Bolliger³

et al. 2009

European Respiratory Journal

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532

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A collaboration of multidisciplinary experts on the functional evaluation of lung cancer patients has been facilitated by the European Respiratory Society (ERS) and the European Society of Thoracic Surgery (ESTS), in order to draw up recommendations and provide clinicians with clear, up-to-date guidelines on fitness for surgery and chemo-radiotherapy.The subject was divided into different topics, which were then assigned to at least two experts. The authors searched the literature according to their own strategies, with no central literature review being performed. The draft reports written by the experts on each topic were reviewed, discussed and voted on by the entire expert panel. The evidence supporting each recommendation was summarised, and graded as described by the Scottish Intercollegiate Guidelines Network Grading Review Group. Clinical practice guidelines were generated and finalised in a functional algorithm for risk stratification of the lung resection candidates, emphasising cardiological evaluation, forced expiratory volume in 1 s, systematic carbon monoxide lung diffusion capacity and exercise testing.Contrary to lung resection, for which the scientific evidences are more robust, we were unable to recommend any specific test, cut-off value, or algorithm before chemo-radiotherapy due to the lack of data. We recommend that lung cancer patients should be managed in specialised settings by multidisciplinary teams.

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Section: Residual Function and Qol After Radical Treatmentmentioning

confidence: 99%

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

Brunelli¹,

Charloux²,

Bolliger³

et al. 2009

European Respiratory Journal

728

532

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“…Possibly for this reason, few studies of long-term survivors have been reported. In a review of 5-year survivorship results, Sugmura and Yang 41 found that a quarter of these long-term survivors had major physical limitations.…”

Section: Studies Within Specific Diseasesmentioning

confidence: 99%

Physical and psychological long-term and late effects of cancer

Stein

Syrjala

Andrykowski

2008

Cancer

548

401

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The number of long-term cancer survivors (5 years after diagnosis) in the U.S.continues to rise, with more than 10 million Americans now living with a history of cancer. Along with such growth has come increasing attention to the continued health problems and needs of this population. Many cancer survivors return to normal functioning after the completion of treatment and are able to live relatively symptom-free lives. However, cancer and its treatment can also result in a wide range of physical and psychological problems that do not recede with time.Some of these problems emerge during or after cancer treatment and persist in a chronic, long-term manner. Other problems may not appear until months or even years later. Regardless of when they present, long-term and late effects of cancer can have a negative effect on cancer survivors' quality of life. This article describes the physical and psychological long-term and late effects among adult survivors of pediatric and adult cancers. The focus is on the prevalence and correlates of long-term and late effects as well as the associated deficits in physical and emotional functioning. In addition, the emergence of public health initiatives and large-scale research activities that address the issues of long-term cancer survivorship are discussed. Although additional research is needed to fully understand and document the long-term and late effects of cancer, important lessons can be learned from existing knowledge. Increased awareness of these issues is a key component in the development of follow-up care plans that may allow for adequate surveillance, prevention, and the management of long-term and late effects of cancer. T he number of long-term cancer survivors (5 years after diagnosis) in the U.S. is increasing because of advances in cancer screening, early detection, treatment strategies, and management of acute treatment toxicities. Indeed, the 5-year survival rate for all cancers combined has risen to 66%, up from approximately 50% in the 1970s, 1 and it is estimated that there are now more than 10 million Americans living with a history of cancer.2 Furthermore, based partly on the overall growth and increasing average age of the U.S. population, researchers are predicting that the number of persons over the age of 65 years diagnosed with cancer each year will double by the year 2050, and will quadruple among those aged 85 years in the same time frame.3 Considered together, these factors suggest that the number of cancer survivors in this country will continue to grow and that their long-term heath problems and resulting needs will demand increasing attention.

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“…7,8 There are only a few exceptional cases when patients with brain metastasis from lung cancer survived for a period longer than 5 years. 9,10 The stable isotopes of hydrogen, deuterium (D) and protium (H), have different chemical and physical behavior. [11][12][13] Bearing in mind that the D-concentration in living organisms is 12 mmol/L and to investigate its possible role in cell cycle regulation, numerous studies have been conducted on cell lines in media prepared with deuterium depleted water (DDW) which proved the pivotal role of D in cell signaling and tumor growth.…”

Section: A Retrospective Evaluation Of the Effects Of Deuterium Deplementioning

confidence: 99%

A Retrospective Evaluation of the Effects of Deuterium Depleted Water Consumption on 4 Patients with Brain Metastases from Lung Cancer

Krempels¹,

Somlyai²,

Somlyai³

2008

Integr Cancer Ther

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172metastasis from lung cancer.3 A considerably longer survival time was achieved only by patients with limited symptoms of the disease who were newly diagnosed thoracic stage I patients bearing a solitary brain metastasis. This subgroup of patients underwent successful brain surgery or stereotactic radiosurgery followed by WBI and achieved an MST of 25.6 months, whereas in patients with a locally advanced primary disease an MST of 9.9 months was achieved. 4 In a trial on stereotactic radiosurgery involving consecutive patients, including those suffering from advanced primary lung cancer and/or multiple brain and/or other distant metastases, the overall MST remained 7.0 months. 5 In a study on recurrent small cell lung carcinoma (SCLC) with brain metastases 6 MST was prolonged by as much as 18 months using radiosurgery. The administration of gefinitib, a tyrosine kinase inhibitor, led to the regression of brain metastases and resulted in an MST of L ung cancer is the leading cause of cancer-related death in men and women. A high percentage of lung cancer patients develop brain metastases resulting in poor prognosis. For a solitary brain metastasis surgical resection, and in the event of multiple metastases, whole brain irradiation (WBI) is considered standard treatment. In addition, aggressive management approaches, including surgical resection with or without WBI or nonsurgical approaches using stereotactic radiosurgery on its own or together with WBI, are standard treatments. Hypotheses. Because of the number of sufferers and high mortality rate, the standard care and new therapeutic options in the treatment of brain metastasis from lung cancer are the subject of intense research. A new concept based on the different chemical and physical behavior of protium and deuterium affecting cell signaling and tumor growth has been introduced in the treatment of cancer patients. The aim of this study was to investigate the impact of deuterium depleted water (DDW) consumption in addition to conventional forms of therapy on the survival of lung cancer patients with brain metastasis. Study design. A series of 4 case histories was retrospectively evaluated. The patients were diagnosed with brain metastasis deriving from a primary lung tumor and started consuming DDW at the time of or after the diagnosis of the brain metastasis, which was inoperable or the surgical intervention did not result in complete regression. The primary objective was survival. Methods. The daily water intake of the patients was replaced with DDW, which complemented the conventional forms of treatment. Patients were consuming DDW for at least 3 months. The treatment was continued with DDW of 10 to 15 to 20 ppm lower deuterium (D) content every 1 to 2 months and thus a gradual decrease was maintained in the D-concentration in the patient's body. Results. DDW consumption integrated into conventional treatments resulted in a survival time of 26.6, 54.6, 21.9, and 33.4 months in the 4 patients, respectively. The brain metastasis of 2 patients showed compl...

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Long-term Survivorship in Lung Cancer

Cited by 148 publications

References 78 publications

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy)

Physical and psychological long-term and late effects of cancer

A Retrospective Evaluation of the Effects of Deuterium Depleted Water Consumption on 4 Patients with Brain Metastases from Lung Cancer

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