Long Term Survival of Primary Skeletal Muscle Lymphoma in a Miniature Dachshund

Takeuchi, Yoshinori; Fujino, Yasuhito; Goto‐Koshino, Yuko; Ohno, Koichi; Uchida, Katsuhisa; Nakayama, Hiroyuki; Tsujimoto, Hajime

doi:10.1292/jvms.09-0454

Cited by 9 publications

(11 citation statements)

References 15 publications

(26 reference statements)

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“…1 Primary muscular lymphoma is a very rare presentation, with only a few canine cases reported, with variable classifications and immunophenotypes. [2][3][4] In cats, muscular lesions have been reported as part of disseminated epitheliotropic T-cell gastrointestinal lymphoma and as part of a nonspecified lymphoid neoplasia. 5,6 To our knowledge, this is the first report of primary muscular PTCL with cutaneous involvement in the dog.…”

Section: Discussionmentioning

confidence: 99%

Primary multifocal muscular T‐cell lymphoma with cutaneous involvement in a dog: A case report and review of the literature

Lopes

Marchesi

Haining

et al. 2021

Veterinary Clinical Pathol

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Canine lymphoma represents a heterogeneous group of lymphoid neoplasms, with multicentric nodal lymphoma being the most common presentation. Musculoskeletal involvement is uncommon, and primary muscular lymphoma is a very rare presentation. Only a few cases have been described in dogs, which were of variable classification and immunophenotype. Here, we report the case of a 5-year-old female neutered Beagle that presented with an intramuscular mass on the right shoulder and associated lameness and lethargy. One month after initial presentation, multiple cutaneous nodules appeared on the head, and staging with advanced imaging revealed additional masses affecting other muscles. Cytology, histopathology, immunohistochemistry, and PCR for antigen receptor rearrangements of one of the muscle masses and skin lesions supported a diagnosis of peripheral T-cell lymphoma with large granular lymphocytes at both sites. The dog was euthanized after diagnosis due to the poor prognosis. This is the first report of primary muscular peripheral T-cell lymphoma with large granular lymphocytes and cutaneous involvement in the dog.Despite being a rare presentation, lymphoma must be considered a differential in dogs presenting with a discrete, intramuscular, soft tissue mass.

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Section: Discussionmentioning

confidence: 99%

Primary multifocal muscular T‐cell lymphoma with cutaneous involvement in a dog: A case report and review of the literature

Lopes

Marchesi

Haining

et al. 2021

Veterinary Clinical Pathol

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“…Canine lymphoma can affect any organ or location, and a wide variety of these atypical form has been reported including oral (Ito et al 2007), periapical (Mendonca et al 2013), nasal (Robertson 1998;Kaldrymidou et al 2000), choanal (Shankel 2005), vertebral (Lamagna et al 2006;Vascellari et al 2007), skeletal (Shell et al 1989;Dhaliwal et al 2001), skeletal muscle (Takeuchi et al 2010), synovial membrane (leading to ruptured cranial cruciate ligament) (Lahmers et al 2002), adrenal (resulting in hypoadrenocorticism) (Labelle and De Cock 2005), renal (Batchelor et al 2006;Durno et al 2011a), urinary bladder (Kessler et al 2008), uterine (Ko et al 2013), prostate (Winter et al 2006;Assin et al 2008), cardiac, andpericardial (Mac-Gregor et al 2005;Aupperle et al 2007) involvement.…”

Section: Atypical Forms Of Canine Lymphomamentioning

confidence: 99%

Canine lymphoma: a review

Zandvliet

2016

Veterinary Quarterly

158

206

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Canine lymphoma (cL) is a common type of neoplasia in dogs with an estimated incidence rate of 20-100 cases per 100,000 dogs and is in many respects comparable to non-Hodgkin lymphoma in humans. Although the exact cause is unknown, environmental factors and genetic susceptibility are thought to play an important role. cL is not a single disease, and a wide variation in clinical presentations and histological subtypes is recognized. Despite this potential variation, most dogs present with generalized lymphadenopathy (multicentric form) and intermediate to high-grade lymphoma, more commonly of B-cell origin. The most common paraneoplastic sign is hypercalcemia that is associated with the T-cell immunophenotype. Chemotherapy is the treatment of choice and a doxorubicin-based multidrug protocol is currently the standard of care. A complete remission is obtained for most dogs and lasts for a median period of 7-10 months, resulting in a median survival of 10-14 months. Many prognostic factors have been reported, but stage, immunophenotype, tumor grade, and response to chemotherapy appear of particular importance. Failure to respond to chemotherapy suggests drug resistance, which can be partly attributed to the expression of drug transporters of the ABC-transporter superfamily, including P-gp and BCRP. Ultimately, most lymphomas will become drug resistant and the development of treatments aimed at reversing drug resistance or alternative treatment modalities (e.g. immunotherapy and targeted therapy) are of major importance. This review aims to summarize the relevant data on cL, as well as to provide an update of the recent literature.

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“…In our dogs the most represented neoplasia was hemangiosarcoma (3/7 cases), with a median age of 10 years, similar to a literature value (9 years) (18). One dog with neoplastic lesions presented a cytological and histological diagnosis of lymphoma, reported to be rare in the literature (22, 23). However, the immunohistochemistry of samples from biopsy was not analyzed and the dog was euthanized 5 days after diagnosis; this dog was 11 years old, slightly older than those mentioned in the literature (8 years) (22, 23).…”

Section: Discussionmentioning

confidence: 99%

Shoulder Lameness in Dogs: Preliminary Investigation on Ultrasonography, Signalment and Hemato-Biochemical Findings Correlation

et al. 2019

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Forelimb lameness in medium and large breed dogs is frequently caused by traumatic or degenerative injuries of the shoulder. Patient history, physical examination, x-rays, blood, and chemical work are routinely used to achieve diagnosis, and may be associated with ultrasonography or magnetic resonance imaging. Ultrasonography is increasingly popular in small animal practice due to its low cost, ease of repetition, and the fact that it is non-invasive and can be performed in conscious patients. It is also widely accepted that muscular stress or injuries can induce detectable variations in blood and chemical work. The aim of this preliminary study is to search for correlation between measurements of selected hematobiochemical parameters and ultrasound diagnosis in dogs affected by shoulder injuries. A retrospective study was conducted on orthopedic clinical records of dogs presented to our Veterinary Teaching Hospital for lameness caused by shoulder problems over a period of 5 years. Dogs with both hematobiochemical and ultrasound examinations were selected. Patients were classified into 5 groups according to ultrasound diagnosis: ( 1 ) mild/moderate tendinopathy, ( 2 ) severe tendinopathy, ( 3 ) articular damage, ( 4 ) chronic myopathy, and ( 5 ) neoplastic injury. Statistical analysis was performed to detect possible correlations between group and hematobiochemical parameters. Forty-four dogs met the inclusion criteria and forty-nine shoulders were diagnosed as injured. Significant differences were found between the age, sex, body weight, neutrophil count, and AST levels. In particular, statistically significant increases were found for neutrophil count and AST concentration in case of ultrasonographically diagnosed severe tendinopathy, articular damage, and neoplastic pathology. Further and wider studies are suggested to determine whether these biomarkers can become a useful diagnostic aid.

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Long Term Survival of Primary Skeletal Muscle Lymphoma in a Miniature Dachshund

Cited by 9 publications

References 15 publications

Primary multifocal muscular T‐cell lymphoma with cutaneous involvement in a dog: A case report and review of the literature

Primary multifocal muscular T‐cell lymphoma with cutaneous involvement in a dog: A case report and review of the literature

Canine lymphoma: a review

Shoulder Lameness in Dogs: Preliminary Investigation on Ultrasonography, Signalment and Hemato-Biochemical Findings Correlation

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