Long-Term Survival of Patients With Heart Failure and Ventricular Conduction Delay Treated With Cardiac Resynchronization Therapy

Auricchio, Angelo; Metra, Marco; Gasparini, Maurizio; Lamp, Barbara; Klersy, Catherine; Curnis, Antonio; Fantoni, Cecilia; Gronda, Edoardo; Vogt, Juergen

doi:10.1016/j.amjcard.2006.07.087

Cited by 82 publications

(80 citation statements)

References 21 publications

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“…Two-hundred and thirtyseven were retrieved for analysis of titles and abstracts and 49 of these were selected for further analysis of the full-length article. Eighteen were considered eligible for inclusion 3,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] .…”

Section: Search Results and Patients' Characteristicsmentioning

confidence: 99%

Cause-of-death analysis in patients with cardiac resynchronization therapy with or without a defibrillator: a systematic review and proportional meta-analysis

et al. 2017

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Section: Search Results and Patients' Characteristicsmentioning

confidence: 99%

Cause-of-death analysis in patients with cardiac resynchronization therapy with or without a defibrillator: a systematic review and proportional meta-analysis

et al. 2017

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“…This is supported by a large multicenter prospective study. 37 In addition, significant mitral regurgitation (grade >2+) post-CRT was found to be independently associated with all-cause mortality, as also described in the Cardiac Resynchronization in Heart Failure Trial 38 and by van Bommel et al 39 Another clinical parameter with impact on mortality was hospitalization due to HF during the first year of follow-up. The importance of HF admissions after CRT was also shown by Bertini et al, 20 and data from the MADIT-CRT trial revealed an association between future events and HF admission during the 12 months before CRT implantation.…”

Section: Discussionmentioning

confidence: 75%

What happens to non-responders in cardiac resynchronization therapy?

Rio

Oliveira

Cunha

et al. 2017

Revista Portuguesa de Cardiologia

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Introduction and Objectives:Left ventricular reverse remodeling (LVRR) is strongly related to the long-term prognosis of patients undergoing cardiac resynchronization therapy (CRT). The aim of this study was to assess the long-term clinical outcome of patients without LVRR at six months after CRT implantation and to determine the prognostic impact of clinical response in this population. Methods: We analyzed 178 consecutive patients who underwent successful CRT device implantation (age 64±11 years; 69% male; 89% in New York Heart Association [NYHA] functional class III; 35% with ischemic cardiomyopathy). Clinical status and echocardiographic parameters were determined before and six months after CRT implantation. We identified those without criteria for LVRR (≥10% increase in left ventricular ejection fraction with ≥15% reduction in left ventricular end-systolic diameter compared to baseline). Clinical responders were defined by a sustained improvement of at least one NYHA functional class. Results: At six-month assessment after CRT, 109 (61%) patients showed LVRR. During a mean follow-up of 56±21 months, 47 (26%) patients died, with higher mortality in the group without LVRR (36% vs. 20%, p=0.023). Clinical response was greater in patients with LVRR (88% vs. 55%, p<0.001). In patients without LVRR, clinical response to CRT was the strongest independent predictor of survival (hazard ratio: 0.120; 95% confidence interval: 0.039-0.366; p<0.001). Conclusion: Although patients without LVRR six months after CRT implantation had a worse prognosis, with higher all-cause mortality, clinical response can be an independent predictor of survival in this population. downloaded from http://www.elsevier.es, day 09/01/2018. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited. Document downloaded from http://www.elsevier.es, day 09/01/2018. This copy is for personal use. Any transmission of this document by any media or format is strictly prohibited. 886 P. Rio et al. PALAVRAS-CHAVE

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“…In Europe, 24% of CRT recipients are women [78], and the corresponding figure in the USA is 22-26% [73], with women comprising 17-24% [79][80][81][82] in larger registry studies of CRT. Although CRT appears to be underutilized in women, the reason for this is unclear.…”

Section: Gender Aspectsmentioning

confidence: 99%

“…In the MADIT-CRT study, the HR for death or HF for CRT-D compared with ICD alone was 0.31 for women and 0.72 for men (P for interaction < 0.01) [65,85]. In single-centre register studies, female gender was protective in some [80,81,86,87] but not in others [79]. In MADIT-CRT, the better prognosis amongst women may be related to baseline differences: women had higher rates of HF of nonischaemic aetiology, LBBB and use of b-blockers but lower rates of right bundle branch block (RBBB), atrial fibrillation (AF) and renal dysfunction.…”

Section: Gender Aspectsmentioning

confidence: 99%

Cardiac resynchronization therapy: a breakthrough in heart failure management

Ståhlberg

Lund

Zabarovskaja

et al. 2012

Journal of Internal Medicine

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Abstract. Stå hlberg M, Lund LH, Zabarovskaja S, Gadler F, Braunschweig F, Linde C (Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden). Cardiac resynchronization therapy: a breakthrough in heart failure management (Review). J Intern Med 2012; 272: 330-343.Heart failure is now considered an epidemic. In patients with heart failure, electrical and mechanical dyssynchrony, evident primarily as prolongation of the QRS-complex on the surface electrocardiogram, is associated with detrimental effects on the cardiovascular system at several levels. In the past 10 years, studies have demonstrated that by stimulating both cardiac ventricles simultaneously, or almost simultaneously [cardiac resynchronization therapy (CRT)], the adverse effects of dyssynchrony can be overcome. Here, we provide a comprehensive overview of different aspects of CRT including the rationale behind and evidence for efficacy of the therapy. Issues with regard to gender effects and patient follow-up as well as a number of unresolved concerns will also be discussed.

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Long-Term Survival of Patients With Heart Failure and Ventricular Conduction Delay Treated With Cardiac Resynchronization Therapy

Cited by 82 publications

References 21 publications

Cause-of-death analysis in patients with cardiac resynchronization therapy with or without a defibrillator: a systematic review and proportional meta-analysis

Cause-of-death analysis in patients with cardiac resynchronization therapy with or without a defibrillator: a systematic review and proportional meta-analysis

What happens to non-responders in cardiac resynchronization therapy?

Cardiac resynchronization therapy: a breakthrough in heart failure management

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