Long‐term survival of head and neck squamous cell carcinoma after bone marrow transplant

Douglas, Catriona; Jethwa, Ashock R.; Hasan, Wael; Liu, Amy; Gilbert, Ralph W.; Goldstein, David P.; Almedia, John De; Lipton, Jeff H.; Irish, Jonathan C.

doi:10.1002/hed.26402

Cited by 11 publications

(10 citation statements)

References 22 publications

(24 reference statements)

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“…GVHD is a reaction of the immune system that occurs when cells from an immunocompetent patient are transplanted into an immunodeficient patient. The risk of developing malignancies secondary to HSCT is multifactorial and after transplantation the incidence of secondary malignancies increases over time ( 1 , 6 , 31 - 33 ). In this sense, the objective of this paper is to present a study on OSCC developed in areas of oral mucosa that had GVHD.…”

Section: Discussionmentioning

confidence: 99%

Oral squamous cell carcinoma arising from areas of Graft-versus-host disease: A systematic review

Monteiro,

Lemos,

Pontes

et al. 2024

Med Oral

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Background Graft-versus-host disease (GVHD) is an immune system reaction that occurs in patients with a history of hematopoietic stem cell transplantation (HSCT), in which the grafted donor's cells attack those of the host. The objective of this systematic review was to present a study on oral squamous cell carcinoma (OSSC) that developed from GVHD areas in patients undergoing HSCT. Material and Methods An electronic search was conducted in the databases PUBMED, WEB OF SCIENCE, SCOPUS, MEDLINE and SCIENCE DIRECT, according to PRISMA guidelines. Results Of the 1582 results, 23 articles were included, resulting in 81 cases. The most common underlying disease for performing the transplant was Myeloid Leukemia (55.6%). The mean age was 39 years, with a predilection for males (64.2%). The tongue was the site of GVHD that most frequently underwent transformation to SCC (59.3%). The average time between transplantation and the development of GVHD was of approximately of 8 months, while the average period of development between transplantation and the development of OSCC was of approximately of 111 months. The most common treatment to GVHD was cyclosporine associated with corticosteroids. Conclusions OSCCs arising from areas of GVHD present a different evolution from conventional oral carcinomas, since they affect younger patients, smoking and alcohol are not important etiological factors and finally because they present good prognosis, but further studies with larger number cases followed are needed to confirm our findings. Key words: Graft vs host disease, squamous cell carcinoma of head and neck, transplantation, homologous.

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Section: Discussionmentioning

confidence: 99%

Oral squamous cell carcinoma arising from areas of Graft-versus-host disease: A systematic review

Monteiro,

Lemos,

Pontes

et al. 2024

Med Oral

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“…Patients who undergo HSCT have been reported to develop tumors at a younger age and higher rate 7,16 . Acute and chronic graft versus host disease after transplant have been associated with increased rates of head and neck malignancy in non‐FA patients and may provide an explanation for why FA patients are at greater risk after transplant 7,17 . Bone marrow radiation and cyclophosphamide are also independent risk factors for malignancy.…”

Section: Discussionmentioning

confidence: 99%

“…7,16 Acute and chronic graft versus host disease after transplant have been associated with increased rates of head and neck malignancy in non-FA patients and may provide an explanation for why FA patients are at greater risk after transplant. 7,17 Bone marrow radiation and cyclophosphamide are also independent risk factors for malignancy. All patients who developed head and neck cancer in our study had undergone HSCT, but our population of un-transplanted patients is too small, (10%), to make a useful comparison.…”

Section: Discussionmentioning

confidence: 99%

Oral Premalignant and Malignant Lesions in Fanconi Anemia Patients

et al. 2022

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Objective There is a lack of data supporting cancer surveillance in pediatric Fanconi Anemia patients. We sought to describe the rates of upper aerodigestive lesions and malignancy in this population to augment current management guidelines. Methods A retrospective cohort study of patients with Fanconi Anemia from a quaternary referral center between 2007–2021 was completed for head and neck cancer risk. Results One hundred and five FA patients were reviewed. Average age at presentation was 11.3 years old and 90.5% of patients underwent hematopoietic stem cell transplant (HSCT). A total of 8.6% of patients had leukoplakia or erythroplakia and 3.8% developed malignancy. The standardized incidence ratio of head and neck malignancy was 483.8. Patients presented with leukoplakia and malignancy at an average age of 14.6 and 25.1 years old, respectively. Malignancies were aggressive and marked by recurrence. There were no premalignant or malignant lesions found on flexible laryngoscopy. This series represents the largest longitudinal series of pediatric FA head and neck lesions. Conclusions Fanconi Anemia patients should begin screening for head and neck cancer at age 10 or after HSCT. Level of Evidence Level 4 Laryngoscope, 133:1745–1748, 2023

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“…It is established that in solid-organ transplanted patients there is a 20 times higher risk of developing secondary malignancy, compared to the general population, mainly due to higher dose of immunosuppressive therapies [ 40 , 41 ]. Douglas et al showed that the most affected site of squamous cell cancer in the head and neck after HSCT was the oral cavity, in particular the tongue, and they showed that cancer in these patients had a more aggressive progression and a poorer prognosis [ 42 ]. In our patient sample, all of the patients were treated with a conditioning chemotherapy regimen, and, among them, three patients also underwent radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Implementation of Routine Endoscopy with Narrow Band Imaging in the Evaluation of Oral and Upper Airways Lesions in Oral Chronic Graft-Versus-Host Disease: A Preliminary Study

Nitro

Pipolo

Castellarin

et al. 2022

JPM

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(1) Background: The aim of our study is to investigate the main oral lesion patterns in patients with oral graft-versus-host disease and to describe and validate the use of endoscopy enhanced with narrow-band imaging (NBI) as a personalized, reliable and user-friendly tool for the early detection of oral potentially diseases. (2) Methods: We retrospectively evaluated the medical records of 20 patients with chronic GVHD and with oral manifestations, who were referred to our “Interdisciplinary Center for Oropharyngeal Pathology (CIPO)” from January 2017 to July 2022. (3) Results: Data on GVHD, oral localization and NBI endoscopic evaluation are collected. A total of six mucositis, one mucosal erythematous change, ten lichenoid-like changes, eight erosive lesions, one leukoplakia, two erythroplakia and two case of blisters were observed. Two vascular abnormalities were seen with NBI, leading to one excisional biopsy. The patient was diagnosed with squamous cell carcinoma. (4) Conclusion: Our study is the first to highlight the relevance of the routine use of endoscopy with NBI in patients with oral chronic GVHD. We highlighted its role as a reliable, reproducible, easy-to-use and tailor-made tool in the follow-up of those patients and to allow an earlier identification of aberrant neoangiogenesis related to oral potentially malignant disorders and oral cancer.

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Long‐term survival of head and neck squamous cell carcinoma after bone marrow transplant

Cited by 11 publications

References 22 publications

Oral squamous cell carcinoma arising from areas of Graft-versus-host disease: A systematic review

Oral squamous cell carcinoma arising from areas of Graft-versus-host disease: A systematic review

Oral Premalignant and Malignant Lesions in Fanconi Anemia Patients

Implementation of Routine Endoscopy with Narrow Band Imaging in the Evaluation of Oral and Upper Airways Lesions in Oral Chronic Graft-Versus-Host Disease: A Preliminary Study

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