Long term survival in pediatric hepatic angiosarcoma (PHAS): A case report and review of the literature

Potanos, Kristina; Hodgkinson, Nicole; Fullington, Nora; Narla, Anupama; Albritton, Karen; Kozakewich, Harry; Kim, Heung Bae

doi:10.1016/j.epsc.2015.08.006

Cited by 11 publications

(22 citation statements)

References 17 publications

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“…Reports are mixed as to whether Type II IHHE is actually a low‐grade AS and therefore malignant. Furthermore, pathologists sometimes classify atypical hepatic vascular lesions that are not clearly AS as Type II IHHE . We believe they are malignant given the propensity of these patients to develop fulminant AS and succumb to this disease…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, pathologists sometimes classify atypical hepatic vascular lesions that are not clearly AS as Type II IHHE. 3 We believe they are malignant given the propensity of these patients to develop fulminant AS and succumb to this disease. 18 We suggest developing a new nomenclature system to better delineate the severity of intermediate lesions and hasten appropriate treatment in patients with true AS.…”

Section: Pediatrmentioning

confidence: 96%

“…AS typically presents in the head and neck in adults compared to skin, deep tissue, or viscera in children . Hepatic AS comprises 1–2% of pediatric liver tumors; fewer than 50 pediatric cases have been reported …”

Section: Introductionmentioning

confidence: 99%

“…2 Hepatic AS comprises 1-2% of pediatric liver tumors; fewer than 50 pediatric cases have been reported. 3 Diagnosing AS is challenging given histology varies from wellformed, anastomosing vessels to solid sheets of high-grade epithelioid or spindled cells with poor vasoformation. 4 Immunohistochemistry is positive for endothelial cell markers CD31 and CD34; podoplanin, a lymphatic marker, may also be present.…”

Section: Introductionmentioning

confidence: 99%

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Clinical case series of pediatric hepatic angiosarcoma

Grassia

Peterman

Iacobas

et al. 2017

Pediatric Blood & Cancer

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Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a "vascular tumor." Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low-grade form of angiosarcoma rather than a benign lesion.

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Section: Discussionmentioning

confidence: 99%

Section: Pediatrmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical case series of pediatric hepatic angiosarcoma

Grassia

Peterman

Iacobas

et al. 2017

Pediatric Blood & Cancer

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“…The overall prognosis is very poor, regardless of treatment or stage, with mean survival time ranging from just 10 months to 2 years . There are only five cases of disease‐free survival reported in the literature …”

Section: Introductionmentioning

confidence: 99%

Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report

Pilbeam

Eidenschink

Sulciner

et al. 2019

Pediatric Transplantation

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Hepatic angiosarcoma is an extremely rare diagnosis in children, with fewer than 50 pediatric cases reported in the literature worldwide. This aggressive vascular sarcoma carries a very dismal prognosis and is known to be resistant to radiation, chemotherapy, and other vascular‐targeted agents. Complete surgical resection is felt to provide the best chance for long‐term survival. In patients with tumors not amenable to resection, a liver transplant can be considered. However, very few such transplants have been reported, given that they remain controversial due to high cancer recurrence and mortality post‐transplant. Herein, we report the unique case of a 2‐year‐old child with localized hepatic angiosarcoma not amendable to resection who successfully underwent a liver transplant and received chemotherapy with six cycles of doxorubicin, docetaxel, and ifosfamide.

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Vascular Anomalies in the Liver

Kelay

Davenport

2022

In Clinical Practice

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Long term survival in pediatric hepatic angiosarcoma (PHAS): A case report and review of the literature

Cited by 11 publications

References 17 publications

Clinical case series of pediatric hepatic angiosarcoma

Clinical case series of pediatric hepatic angiosarcoma

Success of chemotherapy and a liver transplant in a pediatric patient with hepatic angiosarcoma: A case report

Vascular Anomalies in the Liver

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