Long-Term Survival in a Large Cohort of Patients with Venous Thrombosis: Incidence and Predictors

Flinterman, Linda E.; Vlieg, Astrid van Hylckama; Cannegieter, Suzanne C.; Rosendaal, Frits R.

doi:10.1371/journal.pmed.1001155

Cited by 101 publications

(102 citation statements)

References 20 publications

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“…Each DOAC was compared with LMWH + VKA in the reference case, and the results are presented in a tornado plot. 7,24 1.00 NA DVT utility penalty 6,7 0.84 (0.63-1.00) Uniform PE utility penalty 6,7 0.76 (0.57-0.95) Uniform Major bleeding utility penalty 6,7 0.66 (0.50-0.83) Uniform Background mortality 26 2.0 (1.50-2.5)…”

Section: Sensitivity Analysesmentioning

confidence: 99%

Direct Oral Anticoagulants and Vitamin K Antagonists for Treatment of Deep Venous Thrombosis and Pulmonary Embolism in the Outpatient Setting: Comparative Economic Evaluation

Saleh

Berrigan

Anderson

et al. 2017

CJHP

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Section: Sensitivity Analysesmentioning

confidence: 99%

Direct Oral Anticoagulants and Vitamin K Antagonists for Treatment of Deep Venous Thrombosis and Pulmonary Embolism in the Outpatient Setting: Comparative Economic Evaluation

Saleh

Berrigan

Anderson

et al. 2017

CJHP

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“…[1][2][3][4][5][6][7][8][9] A recent study reported an 8-year mortality risk of 12%, 1 whereas in an earlier study, mortality risk reached 50% after 8 years of follow-up. 5 Previous studies were limited by short follow-up time (maximum, 10 years), [1][2][3][4][6][7][8][9][10][11] age restrictions (<70 years of age 1 or between 65 and 89 years of age 7 ), lack of adjustment for comorbidity 3,12 or calendar period, 3,5 and failure to examine mortality for DVT and PE separately. 1,8,12 Only a few studies have compared long-term mortality between VTE patients and a comparison cohort from the general population, with inconsistent results.…”

mentioning

confidence: 99%

30-Year Mortality After Venous Thromboembolism

et al. 2014

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This cohort study drew on the entire Danish population, with 7 046 778 residents alive between 1980 and 2011. Data were obtained from the Danish National Registry of Patients, which Background-Studies on long-term mortality after venous thromboembolism (VTE) are sparse. Methods and Results-Using Danish medical databases, we conducted a 30-year nationwide population-based cohort study of 128 223 patients with first-time VTE and a comparison cohort of 640 760 people from the general population (without VTE) randomly matched by sex, year of birth, and calendar period. The mortality risks for patients with deep venous thrombosis (DVT) and pulmonary embolism (PE) were markedly higher than for the comparison cohort during the first year, especially within the first 30 days (3.0% and 31% versus 0.4%). Using Cox regression, we assessed mortality rate ratios (MRRs) with 95% confidence intervals (CIs The 1-to 10-year and 11-to 30-year MRRs remained 25% to 40% increased after both DVT and PE but were 3-to 5-fold increased after DVT and 6-to 11-fold increased after PE when VTE was considered the immediate cause of death. Conclusions-Patients with VTE are at increased risk of dying, especially within the first year after diagnosis, but also during the entire 30 years of follow-up, with VTE as an important cause of death. Although 30-day mortality after DVT remained fairly constant over the last 3 decades, it improved markedly for PE.

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“…person-years (95% CI 21.0 -24.6) for patients and 4.7 per 1000 person-years (95% CI 4.0 -5.6) for controls [19]. Also, Flinterman et al found that patients with VTE had a 4.0-fold (95% CI 3.7 -4.3) risk of death compared with the control group.…”

Section: Prognosismentioning

confidence: 98%

“…Flinterman et al examined the long-term survival rate in a large cohort of 8 years [19]. The study found that the overall mortality rate was 22.7 per 1000…”

Section: Prognosismentioning

confidence: 99%

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Diagnosis and Treatment Options for Pulmonary Embolism (PE) in the Acute Care Setting

Campa¹,

Gantioque²

2018

WJCD

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Thromboembolic diseases continue to be one of the most prevalent medical problems today and can lead to life-threatening conditions, such as pulmonary embolism (PE). Currently, PE diagnosis and treatment are a challenge because of acute onset right ventricular strain with right-sided heart failure, sudden death, pulmonary infarction, and cardiogenic shock, which limit the time for therapeutic success. The aim of this study was to evaluate our perception, knowledge, and concerns regarding PE, discuss the importance of promptly diagnosing PE to provide appropriate treatment options for this life-threatening condition, list the most common clinical manifestations present when PE is suspected, and review the clinical approach to patients with suspected PE in an inpatient setting. In addition, this study reviews the risk stratification of patients with PE and treatment options beyond anticoagulation, compares new treatment options for patients presenting with acute symptomatic PE, and compares aspiration catheters (10 F Pronto .035" and 14 F XL extraction catheter (Vascular Solutions, Minneapolis, MN)) and ultrasound-assisted catheter-directed thrombolysis (USAT) versus systemic thrombolysis. This literature review was limited by the quality and number of studies available regarding new treatment options for patients presenting with acute symptomatic PE. Thus, more studies are needed to prove the validity of newer treatment options being trialed, such as aspiration catheters (10 F Pronto .035" and 14 F XL extraction catheter) and USAT, with the hope that further studies will guide patient management and increase our understanding of next generation aspiration catheters, which may provide novel insights on treating acute symptomatic PE.

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Long-Term Survival in a Large Cohort of Patients with Venous Thrombosis: Incidence and Predictors

Cited by 101 publications

References 20 publications

Direct Oral Anticoagulants and Vitamin K Antagonists for Treatment of Deep Venous Thrombosis and Pulmonary Embolism in the Outpatient Setting: Comparative Economic Evaluation

Direct Oral Anticoagulants and Vitamin K Antagonists for Treatment of Deep Venous Thrombosis and Pulmonary Embolism in the Outpatient Setting: Comparative Economic Evaluation

30-Year Mortality After Venous Thromboembolism

Diagnosis and Treatment Options for Pulmonary Embolism (PE) in the Acute Care Setting

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