Long‐term survival for a cohort of adults with cerebral palsy

Abstract

The aim of this study was to investigate long-term survival and examine causes of death in adult patients with cerebral palsy (CP). A 1940-1950 birth cohort based on paediatric case referral allows for long-term survival follow-up. Survival is analyzed by birth characteristics and severity of disability from age 20 years (and age 2y for a subset of the data). Survival outcome compared with that expected in the general population based on English life tables. The main cohort consisted of 341 individuals, with 193 males and 148 females. Conditional on surviving to age 20 years, almost 85% of the cohort survived to age 50 years (a comparable estimate for the general population is 96%). Very few deaths were attributed to CP for those people dying over 20 years of age. Females survived better than males. However, females faced a greater increase in risk relative to the general population than did males. We conclude that survival outlook is good though lower than in the general population. The relative risk of death compared with the UK population decreases with age, although it shows some indication of rising again after age 50 years. Many more deaths were caused by diseases of the respiratory system among those dying in their 20s and 30s than would be expected in the general population. Many fewer deaths than expected in this age group are caused by injuries and accidents. For those people who die in their 40s and 50s, an increase in deaths due to diseases of the circulatory system and neoplasms is observed. More deaths than expected in this age group are due to diseases of the nervous system.

The incidence and implications of cerebral palsy following potentially avoidable obstetric complications: a preliminary burden of disease study

“…Survival analyses have shown that each of the domains of QoL primarily affected by CP (ambulation, manual dexterity, cognitive ability, hearing, and vision) possesses similar predictive power with regard to mortality; 16,17 however, GMFCS scores for ambulatory disability are the most common within the survival and QoL literature. We assumed that following the onset of CP, 22.5, 12.5, 18, 25, and 22% would experience ambulatory disability (GMFCS levels 1-5, respectively), as demonstrated by Young et al 18 As long-term QoL data were unavailable for those with CP, we extrapolated point estimates of QoL for those with differing extents of CP-related disability (GMFCS 1-5), 19 in order to represent the QoL experienced by those with CP over their entire lifetimes, as shown in Table 1.…”

Prognóstico motor e perspectivas atuais na paralisia cerebral

“…Aproximadamente 87% das pessoas com PC sobrevivem até os 30 anos 21 e quase 85% dos que passam dos 20 anos sobrevivem até os 50 anos 22 . Diversos fatores influenciam a sobrevida, como o tipo de PC (por exemplo, a quadriplegia espástica tem o pior prognóstico), presença ou não de epilepsia e deficiência mental grave 21 .…”

A Review on Stem Cell Therapy in Cerebral Palsy with a Focus on Motor Function Improvement

“…Furthermore, this disability could be accompanied by mental retardation because of reduced oxygen and also further decrease of supply to neural pathways and neuronal structure (7). The fundamental treatment of CP is the individualized multidisciplinary approach (8). A large part of physical disabilities can be improved by rehabilitation therapy.…”