Long-Term Survival After Repeat Resections of Metastases in Liver, Lung, and Stomach from Sigmoid Colon Cancer: Report of a Case

Yoshimi, Fuyo; Asato, Yuji; Suzuki, Akifumi; Kiyoshima, Moriyuki; Shioyama, Yasukazu; Imura, Johji; Itabashi, Michio

doi:10.1007/s00595-006-3318-2

Cited by 14 publications

(5 citation statements)

References 14 publications

(16 reference statements)

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“…[9] The metastatic spread of original primary cancers to the stomach involves 4 pathways: peritoneal dissemination, hematogenous dissemination, lymphatic spread, and direct tumor invasion. [13] Yoshimi et al [14] presented a case report, very similar to our case, of long-term survival after repeat resections of metastases in the liver, lung, and stomach from sigmoid colon cancer. The patient underwent colectomy for sigmoid colon cancer, repeated hepatectomies (2 times), and pulmonary resection for the metastases.…”

Section: Discussionsupporting

confidence: 80%

Direct gastric invasion from the liver metastasis of colorectal origin: A case report

Nam,

Lee,

Kim

et al. 2024

Medicine

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Rationale: Colorectal cancer is the third most common cancer diagnosed worldwide. At the time of diagnosis of colorectal cancer, one of the most common metastatic sites is liver. Gastric metastasis from colorectal origin is rare. Moreover, a direct invasion of the stomach, by hepatic metastasis from colorectal cancer, is particularly uncommon. Patient concerns: A 56-year-old male patient with hematochezia was referred to our hospital. Diagnosis: The patient was diagnosed with unresectable colorectal cancer because of the presence of >10 metastases involving both lobes of the liver. Interventions and Outcomes: After chemotherapy, the metastatic nodules in the liver nearly disappeared, except for a small nodule in segment VI. The patient underwent a radiofrequency ablation for the single lesion in the liver and laparoscopic low-anterior-resection for the primary tumor. Despite receiving various chemotherapy regimens, he experienced 6 recurrences, leading to 5 hepatectomies including a right hemi-hepatectomy, 1 pulmonary wedge resection, and 2 courses of radiation treatments. Lastly, a metastatic lesion in the liver was observed with invasion into the stomach. Subsequently, gastric wedge resection with resection of segments III and IV of the liver was performed. Direct invasion of the liver metastases into the stomach was confirmed histologically. Lessons: The patient is still alive, with a good quality of life, even after more than 8 years since the initial diagnosis. In the last instance of metastatic recurrence, direct invasion from the liver metastases into the stomach was observed, which is rare, and there are currently no reported cases.

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Section: Discussionsupporting

confidence: 80%

Direct gastric invasion from the liver metastasis of colorectal origin: A case report

Nam,

Lee,

Kim

et al. 2024

Medicine

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“…Previously, there has been a case of gastric metastases arising from signet-ring cell carcinoma of the colon similar to this case [11]. On the other hand, CRC with a well-differentiated adenocarcinoma was also reported to cause gastric metastases [6]. Owing to the lack of multiscale investigation, the biological characterization of gastric metastases from CRC remains unknown; however, histological subtype such as signet-ring cell carcinoma may affect the possibility of metastases at uncommon sites including the stomach.…”

Section: Discussionsupporting

confidence: 67%

“…Gastric metastasis from CRC is extremely rare with only a few cases of gastric metastasis described in the medical literature [ 6 , 7 , 8 , 9 , 10 ]. In our case, the endoscopic findings of gastric metastasis from CRC were precisely clarified.…”

Section: Discussionmentioning

confidence: 99%

Gastric Metastasis from Colorectal Cancer Mimicking a Submucosal Tumor

Iwai

Okuda

Harada

et al. 2020

Case Rep Gastroenterol

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Signet-ring cell carcinoma, a colorectal cancer (CRC) subtype, sometimes shows metastases to uncommon metastatic sites. However, gastric metastasis is extremely rare. Here, we describe a case of gastric metastasis from colonic cancer. A 76-year-old woman presented with anemia. Colonoscopic biopsy revealed a CRC on the transverse colon showing a poorly differentiated adenocarcinoma with a partial component of the signet-ring carcinoma. Computed tomography revealed multiple subcutaneous nodules on her chest and back, and a tumor in the left lower lobe of her lung. Esophagogastroduodenoscopy showed a submucosal tumor-like lesion in the upper gastric body, and endoscopic biopsy revealed the poorly differentiated adenocarcinoma along with the partial component of the signet-ring carcinoma as well as the colonic, subcutaneous, and pulmonary lesion. The findings of endoscopic and microscopic examinations revealed gastric metastasis from CRC on the transverse colon. A systemic chemotherapy was given, and the biopsy conducted 1 year after the initial chemotherapy revealed

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“…Unfortunately, the majority of patients develop recurrent disease within 5 years of surgical resection. A repeated hepatectomy for recurrent hepatic metastases from colorectal cancer is widely accepted as providing good results for selected patients: the mortality, morbidity and long‐term survival after repeated hepatectomies were similar to the results obtained after the first hepatectomy, and repeat resections can be performed with great safety (less than 1% mortality) [19]. Extending the experience with treatment of recurrent colo‐rectal liver metastases, we think that this is a strategy that may be used successfully also in patients with recurrent liver metastases from pancreatic gastrinoma.…”

Section: Discussionmentioning

confidence: 97%

A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection

Pachera

Yokoyama

Nishio

et al. 2009

J Hepatobiliary Pancreat Surg

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Pancreatic gastrinoma is a rare non-beta islet cell tumor. Approximately 60% of gastrinomas are malignant; despite the fact that they are usually slow growing, liver metastases have a major impact on prognosis. Most authors have advocated aggressive surgical management as being the only potentially curative therapy to improve survival as well as to provide outstanding relief from symptoms. We present a case of a 57-year-old man referred to our hospital with a diagnosis of liver metastases from pancreatic gastrinoma, with suspected involvement of the inferior vena cava (IVC). At the age of 37 years, he was diagnosed in his local hospital as having a pancreatic gastrinoma, with liver metastases, and he underwent distal pancreatectomy, splenectomy and enucleation of liver metastases. A liver tumor recurred twice, 7 and 9 years after the first surgery, for which double liver resections were performed: the first time he underwent enucleation of multiple liver metastases in segments II, III, IV, V, VI, VII and VIII, with resection of the right hepatic vein and partially resection of the diaphragm; the second time he underwent enucleation of multiple liver metastases in segments II, III, IV, and V. In our hospital, 8 years after the last surgery, the patient underwent right extended trisectionectomy, resection of segment I, combined resection of the IVC, and partial removal of the diaphragm. To the best of our knowledge, from a review of the literature, this is the first case to achieve successful long-term survival through aggressive surgical management of this type of metastatic endocrine tumor. The patient described here is still alive, free of disease and leading a normal life, 20 years after the initial diagnosis and 3 years after the last surgery.

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Long-Term Survival After Repeat Resections of Metastases in Liver, Lung, and Stomach from Sigmoid Colon Cancer: Report of a Case

Cited by 14 publications

References 14 publications

Direct gastric invasion from the liver metastasis of colorectal origin: A case report

Direct gastric invasion from the liver metastasis of colorectal origin: A case report

Gastric Metastasis from Colorectal Cancer Mimicking a Submucosal Tumor

A rare surgical case of multiple liver resections for recurrent liver metastases from pancreatic gastrinoma: liver and vena cava resection

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